MONTH / YEAR	TITLE	REFERENCE	AUTHORS	COMPOUND NAME	CHEMBRIDGE ID
August-09	Small-Molecule Multidrug Resistance–Associated Protein 1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Models of Neuroblastoma	Cancer Research 69 (16), 6573-80, 2009	Catherine A. Burkhart1, Fujiko Watt3, Jayne Murray3, Marina Pajic3, Anatoly Prokvolit2,4, Chengyuan Xue3, Claudia Flemming3, Janice Smith3, Andrei Purmal1, Nadezhda Isachenko2,4, Pavel G. Komarov1, Katerina V. Gurova2, Alan C. Sartorelli5, Glenn M. Marshall3, Murray D. Norris3, Andrei V. Gudkov1,2,4 and Michelle Haber3
July-09	Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals.	Anesthesiology, July 1, 2009; 111(1): 147-54.	H Wei, MM Hamalainen, M Saarnilehto, A Koivisto, and A Pertovaara	CHEM	5861528
July-09	Chemical Genetic Profiling and Characterization of Small-molecule Compounds That Affect the Biosynthesis of Unsaturated Fatty Acids in Candida albicans	THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 284, NO. 29, 19754–19764	Deming Xu‡1, Susan Sillaots‡, John Davison‡, Wenqi Hu‡, Bo Jiang‡, Sarah Kauffman§, Nick Martel‡, Pam Ocampo‡, Chanseok Oh¶, Steve Trosok‡, Karynn Veillette‡, Hao Wang‡, Minghui Yang‡, Li Zhang‡, Jeffrey Becker§, Charles E. Martin¶, and Terry Roemer‡	ECC120        ECC145          ECC146         ECC003          ECC140        ECC190        ECC188         ECC136	5404696  5404697   5404698    .               .              6632243   6074345
July-09	wwLigCSRre: a 3D ligand-based server for hit identification and optimization	Nucleic Acids Research, 2009, 37, W504-W509 (web server issue)	O. Sperandio1,2, M. Petitjean3 and P. Tuffery1,4,*
June-09	Inhibition of Furin/Proprotein convertase-catalyzed surface and itracellular processing by small molecules	JBC, 284(23), 15729-15738, (2009)	T. Komiyama, J.M. Coppola, M.J. Larsen, M.E. Van Dort, B.D. Ross, R. Day, A. Rehemtulla & R.S. Fuller	B1                     B2                    B6                    B7	.               .                  5472583    5527669
June-09	Sorting in early endosomes reveals connections to docking- and fusion-associated factors	PNAS, 106(24), 9697*9702, 2009	S.V. Barysch, S. Aggarwal, R. Jahn & S.O. Rizzoli	Dynasore
June-09	High-Quality Cost-Effective Compound Management Support for HTS	Journal of Biomolecular Screening, Vol. 14, No. 5, 509-514 (2009)	Maximiliano Zaragoza-Sundqvist, Hans Eriksson, Mattias Rohman & Peter J. Greasley
June-09	Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells	Mol Cancer Ther June 1, 2009, 8, 1473	Zanna Beharry1, Marina Zemskova2, Sandeep Mahajan3, Fengxue Zhang2, Jian Ma4, Zuping Xia1, Michael Lilly6,7, Charles D. Smith1,5 and Andrew S. Kraft5	1a                     3a                     10a                     18a                   20a                    21a                   23a                     24a	5377712   5721666   5377792     5378142               5265182       5376968       5260028       5363403
June-09	Identification and Biochemical Characterization of Small-Molecule Inhibitors of Clostridium botulinum Neurotoxin Serotype A.	Antimicrob. Agents Chemother., June 15, 2009	Virginia Roxas-Duncan, Istvan Enyedy, Vicki A Montgomery, Vanessa S Eccard, Marco A Carrington, Huiguo Lai, Nizamettin Gul, David C H Yang, and Leonard A Smith		7967495   7969312 7968218
June-09	2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells.	Blood, 10 June 2009, 10.1182/blood-2008-11-190587	Andrew J. Steele, Archibald G. Prentice, A. Victor Hoffbrand, Birunthini C. Yogashangary, Stephen M. Hart, Mark W. Lowdell, Edward R. Samuel, Janet M. North, Elisabeth P. Nacheva, Anastasios Chanalaris, Panagiotis Kottaridis, Kate Cwynarski, and R. Gitendra Wickremasinghe	Pifithrin-mu (PAS)	5147472
June-09	Dynasore, a Dynamin Inhibitor, Induces PAI-1 Expression in MeT-5A Human Pleural Mesothelial Cells	Am. J. Respir. Cell Mol. Biol., Jun 2009; 40: 692 - 700.	Chi-Li Chung, Joen-Rong Sheu, Hsiang-Erh Liu, Shi-Chuan Chang, Yung-Chen Chou, Wei-Lin Chen, Duen-Suey Chou, and George Hsiao	Dynasore	5105472
May-09	CD36-mediated cholesterol efflux is associated with PPAR activation via a MAPK-dependent COX-2 pathway in macrophages	Cardiovascular Research, doi:10.1093/cvr/cvp118	Kim Bujold1, David Rhainds1,, Christian Jossart1, Maria Febbraio3, Sylvie Marleau1 and Huy Ong1,2,*	BLT-1	5234221
May-09	TRPA1 in Mast Cell Activation-induced Long-lasting Mechanical Hypersensitivity of Vagal Afferent C fibers in Guinea Pig Esophagus.	Am J Physiol Gastrointest Liver Physiol, May 7, 2009	Shaoyong Yu, Guofeng Gao, Blaise Z Peterson, and Ann Ouyang
May-09	HIGH THROUGHPUT SCREENING FOR WNT/BETA-CATENIN SIGNALING INHIBITORS (AN ORAL PRESENTATION)	Annals of Oncology 20 (Supplement 3):iii-22,2009, O29	W. Lu, J.D. Greenwood, C. Maddox, L. Reddy, S. McKellip, T. Wang, L. Rasmussen, E.L. White, K. Wennerberg, Y. Li
May-09	In Vivo Enhancement of Peptide Display by MHC Class II Molecules with Small Molecule Catalysts of Peptide Exchange1	The Journal of Immunology, 2009, 182: 6342–6352	Melissa J. Call,* Xuechao Xing,† Gregory D. Cuny,†‡ Nilufer P. Seth,¶ Daniel M. Altmann, Lars Fugger,# Michelle Krogsgaard,** Ross L. Stein,†‡ and Kai W. Wucherpfennig2*‡§
May-09	K858, a Novel Inhibitor of Mitotic Kinesin Eg5 and Antitumor Agent, Induces Cell Death in Cancer Cells	Cancer Research 69(9), 3901-9, 2009	Ryuichiro Nakai1, Shin-ichi Iida6,7, Takeshi Takahashi2, Tetsuya Tsujita2, Seiho Okamoto2, Chie Takada3, Kazuhito Akasaka1, Shunji Ichikawa2, Hiroyuki Ishida2, Hideaki Kusaka2, Shiro Akinaga5, Chikara Murakata4, Shinobu Honda6, Masayuki Nitta6, Hideyuki Saya6,7 and Yoshinori Yamashita1	Monastrol	5322014
May-09	The Synthetic Elicitor 3,5-Dichloroanthranilic Acid Induces NPR1-Dependent and NPR1-Independent Mechanisms of Disease Resistance in Arabidopsis	Plant Physiology, May 2009, Vol. 150, pp. 333–347	Colleen Knoth2, Melinda S. Salus, Thomas Girke, and Thomas Eulgem*
May-09	Small molecule screen for compounds that affect vascular development in the zebrafish retina	Mechanisms of Development, Volume 126, Issues 5-6, May-June 2009, Pages 464-477	Satish S. Kitambi, Kyle J. McCullocha, Randall T. Peterson and Jarema J. Malickid	MCBC MBC MCNBC BBC EBC	6959525 5175348 5647831 5648195 5175387 NB MBC also has another ID: 5213896 and the structure of EBC is not correct in the paper
April-09	A Novel, Species-specific Class of Uncompetitive Inhibitors of -Glutamyl Transpeptidase*	J. Biol. Chem., Vol. 284, Issue 14, 9059-9065, April 3, 2009	Jarrod B. King, Matthew B. West, Paul F. Cook, and Marie H. Hanigan1
April-09	In vivo Imaging of Cutaneous T-Cell Lymphoma Migration to the Skin (Priority Report)	Cancer Res 2009;69(7):2704–8	Christoph Hoeller,1,3 Stephen K. Richardson,2 Lai Guan Ng,1,4 Teresa Valero,3 Maria Wysocka,2 Alain H. Rook,2 and Wolfgang Weninger1,4,5
March-09	Chemical Probes that Competitively and Selectively Inhibit Stat3 Activation	PLoS ONE. 2009;4(3):e4783. Epub 2009 Mar 10.	Xu X, Kasembeli MM, Jiang X, Tweardy BJ, Tweardy DJ*.	CPD3       CPD30 CPD188   CPD3-2   CPD3-7    CPD30-12	5544745 5667408 7917648 6745560 7682533 7361776
March-09	Corrected structure of mirin, a small-molecule inhibitor of the Mre11–Rad50–Nbs1 complex	Nature Chemical Biology 5, 130 (2009)	Shaun Peterson, Lily Wang, Kirsten Robertson, Geralda Torchon, Ouathek Ouerfelli & Jean Gautier	Mirin	5378247
January-09	Chemical Biology Investigation of Cell Death Pathways Activated by Endoplasmic Reticulum Stress Reveals Cytoprotective Modulators of ASK1*	J. Biol. Chem., Vol. 284, Issue 3, 1593-1603, January 16, 2009	InKi Kim, Chih-Wen Shu, Wenjie Xu, Chung-Wai Shiau, Daniel Grant, Stefan Vasile, Nicholas D. P. Cosford, and John C. Reed1	Salubrinal CID-2891837 CID-2879344	5147990 6239507 5976228
January-09	ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells	PNAS, Vol 106, 2200-2205, 2009	Qiuyan Wang, Helena Mora-Jensen, Marc A. Weniger, Patricia Perez-Galan, Chris Wolford, Tsonwin Hai, David Ron, Weiping Chen, William Trenkle, Adrian Wiestner, and Yihong Ye	Eeyarestatin I	5138427
January-09	Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1)	Mol. Cancer Ther. 2009; 8:441-448	Wei Guo, Shuhong Wu, Li Wang, Rui-yu Wang, Xiaoli Wei, Jinsong Liu, and Bingliang Fang	Oncrasin-1	5601604
January-09	Macropinocytosis in Shiga toxin 1 uptake by human intestinal epithelial cells and transcellular transcytosis	Am J Physiol Gastrointest Liver Physiol 296: G78-G92, 2009	Irina Malyukova1, Karen F. Murray2, Chengru Zhu 3, Edgar Boedeker 3, Anne Kane 4 Kathleen Patterson 5, Jeffrey R. Peterson6, Mark Donowitz1 and Olga Kovbasnjuk1.	Pirl-1	5137877
January-09	Role for chlamydial type III secretion apparatus in host cytokine expression	Infection and Immunity, January 2009, p. 76-84, Vol. 77, No. 1	Daniel Prantner and Uma M. Nagarajan*	INP0007	5113023
January-09	Virtual Screening and Biological Characterization of Novel Histone Arginine Methyltransferase PRMT1 Inhibitors	ChemMedChem Volume 4, Issue 1, 2009, 69-77	Ralf Heinke 1, Astrid Spannhoff, Dr. 2 3, Rene Meier 1, Patrick Trojer, Dr. 4, Ingo Bauer, Dr. 5, Manfred Jung, Prof. Dr. 2, Wolfgang Sippl, Prof. Dr. 1 *	Compound 1 Compound 2 Compound 3 Compound 4 Compound 5 Compound 6 Compound 7 Compound 8 Compound 9	6000016 7112201 7155176 7736382 6689772 7280948 7789734 5784982 5756663
December-08	Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity	Mol. Pharmacol. 2009; 75:577-588	Joy E. Marlo 1, Colleen M. Niswender 1*, Emily L. Days 1, Thomas M. Bridges 1, Yun Xiang 1, Alice L. Rodriguez 1, Jana K. Shirey 1, Ashley E. Brady 2, Tasha Nalywajko 1, Qingwei Luo 1, Cheryl A. Austin 1, Michael Baxter Williams 1, Kwangho Kim 1, Richard Williams 1, Darren Orton 1, H. Alex Brown 2, Craig W. Lindsley 3, C. David Weaver 3, P. Jeffrey Conn 2	VU 0029767	5723320
December-08	Double-Stranded RNA-Dependent Protein Kinase (PKR)-Dependent Apoptosis Induction by a Novel Small Compound	J. Pharmacol. Exp. Ther. 2009; 328:866-872.	Wenxian Hu, Wayne L. Hofstetter, Xiaoli Wei, Wei Guo, Yanbin Zhou, Abujiang Pataer, Hong Li, Bingliang Fang, and Stephen G. Swisher	BEPP BECC	5650622 5660245
November-08	A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death	Mol Cancer Ther 2008;7(11):3546–55	Tabitha E. Wood1,2, Shadi Dalili1,2, Craig D. Simpson1, Rose Hurren1, Xinliang Mao1, Fernando Suarez Saiz1, Marcela Gronda1, Yanina Eberhard1, Mark D. Minden1, Philip J. Bilan3, Amira Klip3, Robert A. Batey2 and Aaron D. Schimmer1	Fasentin	6094911
November-08	Targeting Type III Secretion in Yersinia pestis	Antimicrob. Agents Chemother. 2009; 53:385-392	Ning J. Pan, Michael J. Brady, John M. Leong, and Jon D. Goguen*	INP0007	5113023
November-08	The Nociceptor Ion Channel TRPA1 is Potentiated and Inactivated by Permeating Calcium Ions	J. Biol. Chem., Vol. 283, Issue 47, 32691-32703	Yuanyuan Wang1,2, Rui B. Chang1,2, Hang N. Waters,1, David D. McKemy1,2, and Emily R. Liman1,2	HC-030031	6106799
November-08	TRPA1 in Bradykinin-induced Mechano-hypersensitivity of Vagal C Fibers in Guinea Pig Esophagus	Am J Physiol Gastrointest Liver Physiol 2009; 296:G255-G265	Shaoyong Yu1* and Ann Ouyang2	HC-030031	6106799
October-08	Small-molecule inhibition of HIV-1 Vif	Nature Biotechnology 26, 1187 - 1192 (2008)	Robin Nathans1, Hong Cao1, Natalia Sharova2, Akbar Ali1, Mark Sharkey2, Ruzena Stranska2, Mario Stevenson2 & Tariq M Rana1,3	RN-18            RN-19            RN-7	6776439 6839806  7023358
October-08	High-Throughput Screening of a 100,000-Compound Library for Inhibitors of Influenza A Virus (H3N2)	Journal of Biomolecular Screening, Vol. 13, No. 9, 879-887 (2008)	William E. Severson, Michael McDowell, Subramaniam Ananthan, Dong-Hoon Chung, Lynn Rasmussen, Melinda I. Sosa, E. Lucile White, James Noah and Colleen B. Jonsson	06-046310        06-070333	7404415    7738919
October-08	2-bromopalmitate and 2-(2-Hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitro	J. Lipid Res. 2009; 50:233-242	Benjamin C. Jennings, Marissa J. Nadolski, Yiping Ling, Meredith Beckham Baker, Marietta L. Harrison, Robert J. Deschenes, and Maurine E. Linder.	Compound I Compound II Compound III Compound V	5269865 5782183 5790443 5657368
October-08	A chemical compound that stimulates the human homologous recombination protein RAD51	PNAS   October 14, 2008   vol. 105   no. 41 15848–15853	Krishanthi Jayathilaka*, Sean D. Sheridan*†, Tyler D. Bold*, Katarzyna Bochenska*, Hillary L. Logan*, Ralph R. Weichselbaum*, Douglas K. Bishop*†‡, and Philip P. Connell*§	RS-1	5253121
October-08	A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication	PNAS   October 21, 2008   vol. 105   no. 42   16119–16124	Kiira Ratiaa, Scott Pegana, Jun Takayamab, Katrina Sleemanc, Melissa Coughlind, Surendranath Balijic, Rima Chaudhuria,e, Wentao Fua, Bellur S. Prabhakard, Michael E. Johnsona, Susan C. Bakerc, Arun K. Ghoshb1, and Andrew D. Mesecara1		7724772
October-08	AMMOS: Automated Molecular Mechanics Optimization tool for in silico Screening	BMC Bioinformatics 2008, 9:438	Tania Pencheva, David Lagorce, Ilza Pajeva, Bruno O Villoutreix, Maria A Miteva
October-08	HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity	Molecular Pain 2008, 4:48	Samer R Eid , Eric D Crown , Eric L Moore , Hongyu A Liang , Kar-Chan Choong , Shelley Dima , Darrell A Henze , Stefanie A Kane  and Mark O Urban	HC-030031	6106799
October-08	Identification and characterization of small-molecule inhibitors of hepsin	Molecular Cancer Therapeutics 7, 3343-3351, October 1, 2008.	John R. Chevillet1,3, Gemma J. Park2, Antonio Bedalov2,4, Julian A. Simon2,5 and Valeri I. Vasioukhin1,6,7	Compound 3 Compound 4 Compound 5	6232890 6071655 5655336
October-08	Identification and Preliminary Characterization of a New Chemical Affecting Glucosyltransferase Activities Involved in Plant Cell Wall Biosynthesis	Molecular Plant 2008 1(6):977-989	Olga Zabotinaa,c, Erik Malmb, Georgia Drakakakia, Vincent Buloneb and Natasha Raikhela,1	Compound A	6240780
September-08	Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats	J. Pharmacol. Exp. Ther. 2008; 327:941-953	Ashley E. Brady 1, Carrie K. Jones 2, Thomas M. Bridges 2, J. Phillip Kennedy 2, Analisa D. Thompson 2, Justin U. Heiman 2, Micah L. Breininger 2, Patrick R. Gentry 2, Huiyong Yin 2, Satyawan B. Jadhav 2, Jana K. Shirey 2, P. Jeffrey Conn 2, Craig W. Lindsley 2*		4003557
September-08	Chemical substructures that enrich for biological activity	Bioinformatics. 2008; 24:2518-2525	Justin Klekota and Frederick P. Roth
September-08	FAF-Drugs2: Free ADME/tox filtering tool to assist drug discovery and chemical biology projects	BMC Bioinformatics. 2008; 9: 396	Reviewed by David Lagorce,1 Olivier Sperandio,1 Hervé Galons,2 Maria A Miteva,1 and Bruno O Villoutreix1
September-08	Host Scavenger Receptor SR-BI Plays a Dual Role in the Establishment of Malaria Parasite Liver Infection	Cell Host & Microbe, Volume 4, Issue 3, 271-282, 11 September 2008	Cristina D. Rodrigues1,2,8,Michael Hannus3,8,Miguel Prudêncio1,2,8,Cécilie Martin3,Lígia A. Gonçalves2,Sílvia Portugal1,Sabrina Epiphanio1,Akin Akinc4,Philipp Hadwiger5,Kerstin Jahn-Hofmann5,Ingo Röhl5,Geert-Jan van Gemert6,Jean-François Franetich7,Adrian J.F. Luty6,Robert Sauerwein6,Dominique Mazier7,Victor Koteliansky4,Hans-Peter Vornlocher5,Christophe J. Echeverri3andMaria M. Mota1,2,	BLT-1 BLT-2 BLT-4	5234221 5234225 5109586
September-08	ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells	Virology. 2008 Sep 30;379(2):197-204	Bryant KF, Macari ER, Malik N, Boyce M, Yuan J, Coen DM.	Salubrinal	5147990
September-08	Identification of a Small Molecule with Synthetic Lethality for K-Ras and Protein Kinase C Iota	Cancer Research 68, 7403-7408, September 15, 2008	Wei Guo1, Shuhong Wu1, Jinsong Liu2 and Bingliang Fang1	Oncrasin-1	5601604
September-08	New auxin analogs with growth-promoting effects in intact plants reveal a chemical strategy to improve hormone delivery	PNAS September 30, 2008 vol. 105 no. 39 15190-15195	Sigal Savaldi-Goldstein*,†, Thomas J. Baiga‡, Florence Pojer‡,§, Tsegeye Dabi*, Cristina Butterfield*, Geraint Parry¶, Aaron Santner¶, Nihal Dharmasiri¶,‖, Yi Tao*,**, Mark Estelle¶, Joseph P. Noel‡,††, and Joanne Chory*,††,‡‡	602 533 5265 5353	6027864 5336619 5353053 5265305
September-08	Pmp-Like Proteins Pls1 and Pls2 Are Secreted into the Lumen of the Chlamydia trachomatis Inclusion	Infection and Immunity, September 2008, p. 3940-3950, Vol. 76, No. 9	Ine Jorgensen and Raphael H. Valdivia*	C1	5113023
August-08	A TR3/Nur77 Peptide-Based High-Throughput Fluorescence Polarization Screen for Small Molecule Bcl-B Inhibitors	Journal of Biomolecular Screening, Vol. 13, No. 7, 665-673 (2008)	Yip KW, Godoi PH, Zhai D, Garcia X, Cellitti JF, Cuddy M, Gerlic M, Chen Y, Satterthwait A, Vasile S, Sergienko E, Reed JC	BIM-0034173 BIM-0001329	5804000 5954623
August-08	LDLs stimulate p38 mitogen-activated kinases and wound healing through the class B type 1 scavenger receptor independently of Ras and PI3 kinase	Journal of Lipid Research, Vol. 50, 81-89, January 2009	Natasa Bulat, Gérard Waeber, and Christian Widmann	BLT-1	5234221
August-08	Lycopene Absorption in Human Intestinal Cells and in Mice Involves Scavenger Receptor Class B Type I but Not Niemann-Pick C1-Like 1	J. Nutr. 138:1432-1436, August 2008	Myriam Moussa3–5, Jean-François Landrier3–5, Emmanuelle Reboul3–5, Odette Ghiringhelli3–5, Christine Coméra6, Xavier Collet6, Kati Fröhlich7, Volker Böhm7 and Patrick Borel3–5*	BLT-1	5234221
August-08	N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds	Bioorg Med Chem Lett. 2008 Aug 1;18(15):4328-31	Manetti F, Falchi F, Crespan E, Schenone S, Maga G, Botta M.	Compound 3 Compound 6 Compound 11 Compound 13	5854919 7917472 7917469 7917459
August-08	Small Molecules Can Selectively Inhibit Ephrin Binding to the EphA4 and EphA2 Receptors	J. Biol. Chem., Vol. 283, Issue 43, 29461-29472, October 24, 2008	Roberta Noberinia,b, Mitchell Koolpea, Satyamaheshwar Peddibhotlac, Russell Dahla, Ying Sua, Nicholas D. P. Cosforda, Gregory P. Rothc, and Elena B. Pasqualea,d*	Compound 1 Compound 2	5987008 5965041 Compound 1 is also known as NB-2 from a previous publication in 2004
August-08	The effect of particle design on cellular internalization pathways	PNAS August 19, 2008 vol. 105 no. 33 11613-11618	Stephanie E. A. Gratton*, Patricia A. Ropp*, Patrick D. Pohlhaus*, J. Christopher Luft*, Victoria J. Madden†, Mary E. Napier*, and Joseph M. DeSimone†‡§¶	Dynasore	5105472
July-08	Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP-3	The FASEB Journal. 2008;22:2311-2322	Raphael Rozenfeld and Lakshmi A. Devi	Dynasore	5105472
July-08	A novel druglike spleen tyrosine kinase binder prevents anaphylactic shock when administered orally	J Allergy Clin Immunol. 2008 Jul;122(1):188-94	Mazuc E, Villoutreix BO, Malbec O, Roumier T, Fleury S, Leonetti JP, Dombrowicz D, Daëron M, Martineau P, Dariavach P	C-13	6197026
July-08	Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4	Mol Pharmacol 74:1345-1358, 2008	Colleen M. Niswender 1*, Kari A. Johnson 2, C. David Weaver 2, Carrie K. Jones 1, Zixiu Xiang 1, Qingwei Luo 1, Alice L. Rodriguez 1, Joy E. Marlo 1, Tomas de Paulis 1, Analisa D. Thompson 1, Emily L. Days 1, Tasha Nalywajko 1, Cheryl A. Austin 1, Michael Baxter Williams 1, Jennifer E. Ayala 1, Richard Williams 1, Craig W. Lindsley 3, P. Jeffrey Conn 4	VU 0003423	7307507
June-08	“Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets	Pharmacol. Rev. 2008 60:181-195	KAZUAKI TAKABE, STEVEN W. PAUGH, SHELDON MILSTIEN, AND SARAH SPIEGEL	2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole	5663543
June-08	Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Human Intrauterine Growth Restriction	American Journal of Pathology. 2008;173:451-462	Hong-wa Yung*, Stefania Calabrese, Debby Hynx, Brian A. Hemmings, Irene Cetin, D. Stephen Charnock-Jones and Graham J. Burton*	Salubrinal	5147990
June-08	Identification of non-lipid LPA3 antagonists by virtual screening	Bioorg Med Chem. 2008 Jun 1;16(11):6207-17	Fells JI, Tsukahara R, Fujiwara Y, Liu J, Perygin DH, Osborne DA, Tigyi G, Parrill AL		5105099 5186303 5226501 6636019 6637041
May-08	Identification of auxins by a chemical genomics approach	Journal of Experimental Botany, Vol. 59, No. 10, pp. 2757–2767, 2008	May Christian1, William B. Hannah1, Hartwig Lüthen2 and Alan M. Jones1,*	WH7 WH7A WH7B WH7C WH7E	6156005 6215658 6201133 5530074 6229098
May-08	Inhibitors of bacterial multidrug efflux pumps potentiate antimicrobial photoinactivation	Antimicrobial Agents and Chemotherapy, September 2008, p. 3202-3209, Vol. 52, No. 9	George P Tegos, Kayo Masago, Fatima Aziz, Andrew Higginbotham, Frank R Stermitz, and Michael R. Hamblin*	INF 271	5109586
May-08	Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator	Cancer Cell, Volume 13, Issue 5, 454-463, 6 May 2008	Sonia Lain1,Jonathan J. Hollick4,Johanna Campbell1,Oliver D. Staples1,Maureen Higgins1,Mustapha Aoubala1,Anna McCarthy1,4,Virginia Appleyard1,Karen E. Murray1,Lee Baker1,Alastair Thompson1,Joanne Mathers1,Stephen J. Holland5,Michael J.R. Stark5,Georgia Pass2,Julie Woods3,David P. Lane6andNicholas J. Westwood4	Tenovin-1	6504104
April-08	Cardiogenic small molecules that enhance myocardial repair by stem cells	PNAS   April 22, 2008   vol. 105   no. 16   6063–6068	Hesham Sadek*, Britta Hannack*, Elizabeth Choe*, Jessica Wang*, Shuaib Latif*, Mary G. Garry*, Daniel J. Garry*, Jamie Longgood†, Doug E. Frantz†, Eric N. Olson‡, Jenny Hsieh‡, and Jay W. Schneider*§	SHZ-1	5560932
April-08	Single Particle Characterization of Iron-induced Pore-forming -Synuclein Oligomers	J. Biol. Chem., Vol. 283, Issue 16, 10992-11003, April 18, 2008	Marcus Kostka12, Tobias Högen1, Karin M. Danzer1, Johannes Levin¶, Matthias Habeck, Andreas Wirth||, Richard Wagner**, Charles G. Glabe, Sabine Finger, Udo Heinzelmann, Patrick Garidel, Wenzhen Duan, Christopher A. Ross, Hans Kretzschmar, and Armin Giese3	293G02 301C09 307F06 305E04	5260186 5286810 5323932 5315106
April-08	Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway	PNAS   April 29, 2008   vol. 105   no. 17 6302-6307	J. E. Kravchenko*†, G. V. Ilyinskaya*†‡, P. G. Komarov§¶, L. S. Agapova*‡, D. V. Kochetkov*†, E. Strom§¶, E. I. Frolova , I. Kovriga , A. V. Gudkov*,**, E. Feinstein§, and P. M. Chumakov*†,††	RETRA	5493343
April-08	Changes in PSAC Reduce Leupeptin Uptake and Can Confer Drug Resistance in P. falciparum-Infected Erythrocytes	Antimicrob. Agents Chemother. 28 April 2008, 10, 1128	Godfrey Lisk1, Margaret Pain1, Ilya Y. Gluzman3, Shivkumar Kambhampati1, Tetsuya Furuya1, Xin-zhuan Su1, Michael P. Fay2, Daniel E. Goldberg3, and Sanjay A. Desai1*	NPF-1	6574929
April-08	Identification of a Novel Retinoid by Small Molecule Screening with Zebrafish Embryos	PLoS ONE 1 April 2008, Volume 3, Issue 4, e1947	Chetana Sachidanandan, Jing-Ruey J. Yeh, Quinn P. Peterson, Randall T. Peterson*	DTAB	5133623
April-08	MS-DOCK: Accurate multiple conformation generator and rigid docking protocol for multi-step virtual ligand screening	BMC Bioinformatics. 2008; 9: 184.	Nicolas Sauton,1 David Lagorce,1 Bruno O Villoutreix,1 and Maria A Miteva1
March-08	A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPAR and PPAR activities	Molecular Cancer Therapeutics 7, 521-529, March 1, 2008	Shlomo Handeli and Julian A. Simon	FH535 FH525 unknown FH610 FH614	5351170 5253512 5211152 6107659 6142955
March-08	Inhibition of p97-dependent Protein Degradation by Eeyarestatin I	J. Biol. Chem., Vol. 283, Issue 12, 7445-7454, March 21, 2008	Qiuyan Wang, Lianyun Li, and Yihong Ye1	Eeyarestatin I	5138427
March-08	Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells	Chemistry & Biology, Volume 15, Issue 3, 234-245, 21 March 2008	Wan Seok Yang1andBrent R. Stockwell1,2,	RSL5	5707885
March-08	Thiobarbiturates as Sirtuin Inhibitors: Virtual Screening, Free-Energy Calculations, and Biological Testing	ChemMedChem 2008, 3, 1–13 (not final citation)	Urszula Uciechowska,[a] Jçrg Schemies,[b] Robert C. Neugebauer,[b] Elisabeth-Maria Huda,[b] Martin L. Schmitt,[b] Rene Meier,[a] Eric Verdin,[c] Manfred Jung,[b] and Wolfgang Sippl*[a]	Compound 7 Compound 8 Compound 9 Compound 10 Compound 11	6958028 6988938 5327543 5549466 5240507
February-08	Inhibition of human parainfluenza virus type 3 infection by novel small molecules	Antiviral Res. 2008 Feb;77(2):83-94	Mao H, Thakur CS, Chattopadhyay S, Silverman RH, Gudkov A, Banerjee AK	C5 C7	5855229 5857852
February-08	Structure–Activity Studies on Splitomicin Derivatives as Sirtuin Inhibitors and Computational Prediction of Binding Mode	J. Med. Chem. 2008, 51, 1203–1213	Robert C. Neugebauer,† Urszula Uchiechowska,‡ Rene Meier,‡ Henning Hruby,† Vassil Valkov,† Eric Verdin,§ Wolfgang Sippl,‡ and Manfred Jung*,†	Compound 11a Compound 11b Compound 11c Compound 11d	5607701 7290417 7265524 6437473
February-08	Virtual screening approaches for the identification of non-lipid autotaxin inhibitors	Bioorg Med Chem. 2008 Feb 15;16(4):1784-95	Parrill AL, Echols U, Nguyen T, Pham TC, Hoeglund A, Baker DL		7905958
January-08	A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death	Cell Death and Differentiation (2008) 15, 589–599	M Boyce1,5, B F Py1, A G Ryazanov2, J S Minden3, K Long4, D Ma4 and J Yuan1	Salubrinal	5147990
January-08	Receptor-Based Virtual Ligand Screening for the Identification of Novel CDC25 Phosphatase Inhibitors	J. Chem. Inf. Model. 2008, 48, 157-165	Matthieu Montes,†,‡,§ Emmanuelle Braud,†,‡,§ Maria A. Miteva,‡,§ Mary-Lore`ne Goddard,‡,§ Odile Monde´sert,| Ste´phanie Kolb,‡,§ Marie-Priscille Brun,‡,§ Bernard Ducommun,| Christiane Garbay,‡,§ and Bruno O. Villoutreix*,‡,§	Compound 1 Compound 2 Compound 3 Compound 4 Compound 5	5666005 6017246 7007260 7980118 5673755
January-08	Identification of cellular pathways affected by Sortin2, a synthetic compound that affects protein targeting to the vacuole in Saccharomyces cerevisiae	BMC Chemical Biology 2008, 8:1	Lorena Norambuena* 1,3 , Jan Zouhar* 2,3 , Glenn R Hicks3  and Natasha V Raikhel3	Sorttin 2	6239069
January-08	Mechanism of Inhibition of HIV-1 Reverse Transcriptase by the Novel Broad-Range DNA Polymerase Inhibitor N-{2-[4-(Aminosulfonyl)phenyl]ethyl}-2-(2-thienyl)acetamide	Biochemistry 2008, 47 (1), 490-502	Alon Herschhorn, Iris Oz-Gleenberg, and Amnon Hizi*	NAPETA MDBACEC	6613838 7840607
January-08	Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis	Methods Enzymol. 2008;438:77-93	Kirchhausen T, Macia E, Pelish HE	Dynasore	5105472
December-07	An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission	Nature Chemical Biology 4, 42 - 50 (2007)	Jana K Shirey1,5, Zixiu Xiang1,5, Darren Orton2,3, Ashley E Brady1, Kari A Johnson1, Richard Williams2,3, Jennifer E Ayala1, Alice L Rodriguez1,2, Jürgen Wess4, David Weaver1,2, Colleen M Niswender1,2 & P Jeffrey Conn1,2	Compound 12 Compound 15 Compound 16 (from Fig 1a)	7904200 7911703 7912361
December-07	Novel Antiviral Agents Targeting HIV Entry and Transmission*	VIROLOGICA SINICA, December 2007, 22 (6):451-461	Qinxue Hu1.2** and Robin Shattock1	NBD-556 NBD-557	5849968 5857355
December-07	Arabidopsis P-Glycoprotein19 Participates in the Inhibition of Gravitropism by Gravacin	Chemistry & Biology, Volume 14, Issue 12, 26 December 2007, Pages 1366-1376	Marcela Rojas-Pierce, Boosaree Titapiwatanakun, Eun Ju Sohn, Fang Fang, Cynthia K. Larive, Joshua Blakeslee, Yan Cheng, Sean Cuttler, Wendy A. Peer, Angus S. Murphy, Natasha V. Raikhel	Gravacin	5850247
December-07	BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development	Toxicol Lett. 2007 Dec 10;175(1-3), 1-7	Raldúa D, Babin PJ	BLT-1	5234221
December-07	Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells	J Neurochem. 2007 Dec;103(5):2004-14	Xu X, Chua CC, Kong J, Kostrzewa RM, Kumaraguru U, Hamdy RC, Chua BH.	Necrostatin-1	5115808
December-07	Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop adaptability in selective inhibition of bacterial enzymes	BMC Struct Biol. 2007; 7: 84	Ze-Qiang Ma,1 Sheng-Xue Xie,1 Qing-Qing Huang,2 Fa-Jun Nan,2 Thomas D Hurley,3 and Qi-Zhuang Ye1,3	Compound 1 Compound 2 Compound 3 Compound 6 Compound 7	6025190 6009336 6281056 6108575 6029521
November-07	Chemical genetic interrogation of natural variation uncovers a molecule that is glycoactivated	Nature Chemical Biology 3, 716-721 (2007)	Yang Zhao1, Tszfung F Chow1, Rachel S Puckrin1, Simon E Alfred1, Albert K Korir2, Cynthia K Larive2 & Sean R Cutler3	Hypostatin Chuboxypyr Pyrabactin B	5568575 5472086 5656942
November-07	Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism	Nature Chemical Biology 4, 33 - 41 (2007)	Paul B Yu1,2,6, Charles C Hong1,5,6, Chetana Sachidanandan1,6, Jodie L Babitt3, Donna Y Deng1, Stefan A Hoyng1, Herbert Y Lin3, Kenneth D Bloch1,4 & Randall T Peterson1,2
October-07	Non-carbohydrate inhibitors of Lectin DC-Sign	JACS, 129(42), 12780-12785, 2007	M.J. Borrok & L.L. Kiessling	7	5841572
October-07	Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis	J. Med. Chem. 2007, 50, 5735-5742	Min Huang,‡ Sheng-Xue Xie,‡ Ze-Qiang Ma,‡ Qing-Qing Huang,§ Fa-Jun Nan,§ and Qi-Zhuang Ye*,‡,|	Compound 1 Compound 3	6025190 5730590
October-07	Inhibitors of Ubiquitin-Activating Enzyme (E1), a New Class of Potential Cancer Therapeutics	Cancer Res 2007; 67: (19). October 1, 9472	Yili Yang,1 Jirouta Kitagaki,1 Ren-Ming Dai,2 Yien Che Tsai,1 Kevin L. Lorick,1 Robert L. Ludwig,4 Shervon A. Pierre,1 Jane P. Jensen,1 Ilia V. Davydov,5 Pankaj Oberoi,5 Chou-Chi H. Li,2 John H. Kenten,5 John A. Beutler,3 Karen H. Vousden,4 and Allan M. Weissman	PYR-41 PYR-495 PYR-19	5631437 5535902 5562254
September-07	Small molecules not direct activators of caspases	NATURE CHEMICAL BIOLOGY VOLUME 3 NUMBER 9 SEPTEMBER 2007	Jean-Bernard Denault1, Marcin Drag1, Guy S Salvesen1, Juliano Alves2, Analeah B Heidt2, Quinn Deveraux2 & Jennifer L Harris2	PAC-1	5851625
August-07	Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening	Bioorganic & Medicinal Chemistry 15 (2007) 6810–6818	Kazunori Hirayama,a,b Shunsuke Aoki,b,* Kaori Nishikawa,b Takashi Matsumotoa and Keiji Wada,b	Compound 1 Compound 6 Compound 7	7504601 6237842 6771097
August-07	Linking SIRT2 to Parkinson’s Disease	ACS CHEMICAL BIOLOGY, 2, No 8, 529	Adam L. Garske†,§, Brian C. Smith†,§, and John M. Denu‡,*	B2 AGK2 AK-1	6133799 5857140 6642056
August-07	Necrostatin: a potentially novel cardioprotective agent?	Cardiovasc Drugs Ther. 2007 Aug;21(4):227-33	Smith CC, Davidson SM, Lim SY, Simpkin JC, Hothersall JS, Yellon DM	Necrostatin-1	5115808
July-07	Novel antagonists of the thioesterase domain of human fatty acid synthase	Mol Cancer Ther;6(7). July 2007 2120	Robyn D. Richardson and Jeffrey W. Smith	Compound 1 Compound 2 Compound 3 Compound 4 (from Table 2)	6904884 6320820 5993555 5989330
July-07	Sirtuin 2 Inhibitors Rescue a-Synuclein–Mediated Toxicity in Models of Parkinson’s Disease	Science 27 JULY 2007 VOL 317 516 - 519	Tiago Fleming Outeiro,1,2 Eirene Kontopoulos,3* Stephen M. Altmann,2* Irina Kufareva,4 Katherine E. Strathearn,5 Allison M. Amore,2 Catherine B. Volk,5 Michele M. Maxwell, 2 Jean-Christophe Rochet,5 Pamela J. McLean,1,2 Anne B. Young,2 Ruben Abagyan,4 Mel B. Feany,3 Bradley T. Hyman,1,2 Aleksey G. Kazantsev2†	AGK2 AK-1	5857140 6642056
July-07	Inhibition of Type III Secretion in Salmonella enterica Serovar Typhimurium by Small-Molecule Inhibitors	Antimicrob Agents Chemother. 2007; 51(7): 2631–2635.	Debra L. Hudson,1† Abigail N. Layton,1† Terry R. Field,1 Alison J. Bowen,1 Hans Wolf-Watz,2 Mikael Elofsson,3 Mark P. Stevens,1 and Edouard E. Galyov1*	INP0007	5113023
June-07	Small molecules enhance autophagy and reduce toxicity in Huntingdon's disease models	Nat Chem Biol, 3(6), 331-338 (2007)	S. Sarkar, E.O. Perlstein, S. Imarisio, S. Pineau, A. Cordenier, R.L. Maglathlin, J.A. Webster, T.A.Lewis, C.J. O'Kane, S.L. Schreiber & D.C. Rubinszstein
June-07	Discovery of a Highly Active Ligand of Human Pregnane X Receptor: A Case Study from Pharmacophore Modeling and Virtual Screening to “In Vivo” Biological Activity	MOLECULAR PHARMACOLOGY Vol. 72, No. 3, 2007	Geraldine Lemaire, Cindy Benod, Virginie Nahoum, Arnaud Pillon, Anne-Marie Boussioux, Jean-Franc¸ois Guichou, Guy Subra, Jean-Marc Pascussi, William Bourguet, Alain Chavanieu, and Patrick Balaguer	CB2BA-4 CB2BA-5 CB2BA-6 CB2BA-7 CB2BA-8 CB2BA-10 CB2BA-13 CB2BA-248 CB2BA-251 NB in the paper both C2BA-248 & CB2A-251 have the same structure	7896130 7754300 7931751 7960156 7902591 7906112 7988475 7976441
June-07	Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein–protein complexes	PNAS   June 19, 2007   vol. 104   no. 25 10370-10375	Julien Viaud*†, Mahel Zeghouf‡, He´ le`ne Barelli§, Jean-Christophe Zeeh‡, Andre´ Padilla*†, Bernard Guibert‡, Pierre Chardin§, Catherine A. Royer*†, Jacqueline Cherfils‡¶, and Alain Chavanieu*†	LM11	5340426
June-07	The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Gα-interaction face	BBA-Proteins & Proteomics 2007, 1774 (9), 1213-1220.	Adam J. Kimple a, Francis S. Willard a, Patrick M. Giguère a, Christopher A. Johnston a, Viorel Mocanu b, David P. Siderovski a,c,⁎	CCG 4986	7003154
June-07	TRPA1 Mediates Formalin-induced Pain	PNAS, 104 (33): 13525-13530, 2007	CR McNamara, J Mandel-Brehm, DM Bautista, J Slemens, KL Deranian, M Zhao, NJ Hayward, JA Chong, D Julius, MM Moran, and CM Fanger	HC-030031	6106799
June-07	Small-molecule activators of RNase L with broad-spectrum antiviral activity	PNAS June 5, 2007 vol. 104 no. 23 9585–9590	Chandar S. Thakur*†, Babal Kant Jha*, Beihua Dong*, Jaydip Das Gupta*, Kenneth M. Silverman*, Hongxia Mao‡, Hiro Sawai§, Akiko O. Nakamura§, Amiya K. Banerjee‡, Andrei Gudkov‡, and Robert H. Silverman*¶		5966451, 6645744, 7023139, 5950331, 6474572, 5142087, 5972155, 5973265, 5947495, 6131864, 6131645, 6131416
April-07	Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants	Nature Chemical Biology 3, 287 - 296 (2007)	Qiaojie Xiong, Haiyan Sun & Min Li
April-07	eIF2α Phosphorylation Bidirectionally Regulates the Switch from Short- to Long-Term Synaptic Plasticity and Memory	Cell, Volume 129, Issue 1, Pages 195-206	Mauro Costa-Mattioli1,  Delphine Gobert6, Elad Stern7, Karine Gamache2, Rodney Colina1, Claudio Cuello3, Wayne Sossin4, Randal Kaufman8, Jerry Pelletier1, Kobi Rosenblum7, Krešimir Krnjević5, Jean-Claude Lacaille6, Karim Nader2 and Nahum Sonenberg1,	Sal003	5147990
March-07	Identification of Anti-prion Compounds as Efficient Inhibitors of Polyglutamine Protein Aggregation in a Zebrafish Model	J. Biol. Chem., Vol. 282, Issue 12, 9195-9203, March 23, 2007	Niclas W. Schiffer, Sarah A. Broadley, Thomas Hirschberger, Paul Tavan, Hans A. Kretzschmar¶, Armin Giese¶, Christian Haass||, F. Ulrich Hartl1, and Bettina Schmid||2	313B02	5344362
March-07	Pseudolipasin A Is a Specific Inhibitor for Phospholipase A2 Activity of Pseudomonas aeruginosa Cytotoxin ExoU ,	Infection and Immunity, March 2007, p. 1089-1098, Vol. 75, No. 3	Vincent T. Lee,1* Stefan Pukatzki,1 Hiromi Sato,4 Eriya Kikawada,2 Anastasia A. Kazimirova,1 Jin Huang,1 Xiaohua Li,3 Jonathan P. Arm,2 Dara W. Frank,4 and Stephen Lory1	Pseudolipasin A	5633885
February-07	Chemical genetic approaches to probing cell death	Curr Opin Chem Biol. 2007 Feb;11(1):83-7	Gangadhar NM, Stockwell BR	Necrostatin-1	5115808
January-07	Identification of Small-Molecule Inhibitors of RGS4 Using a High-Throughput Flow Cytometry Protein Interaction Assay	Mol Pharmacol 71:169–175, 2007	David L. Roman, Jeffery N. Talbot, Rebecca A. Roof, Roger K. Sunahara, John R. Traynor, and Richard R. Neubig	CCG 4986	7003154
January-07	Structure-based discovery of new small molecule inhibitors of low molecular weight protein tyrosine phosphatase	European Journal of Medicinal Chemistry 2007, 42, 1102-1108	David Vidal a, Jascha Blobel a, Yolanda Pe´rez a, Michael Thormann b,1, Miquel Pons a,c,*	ptp-194	5847860
January-07	Small-Molecule Inhibition of the Interaction between the Translation Initiation Factors eIF4E and eIF4G	Cell, Vol 128, 257-267, 26 January 2007	Nathan J. Moerke,1 Huseyin Aktas,2 Han Chen,2 Sonia Cantel,2 Mikhail Y. Reibarkh,1 Amr Fahmy,1 John D. Gross,1,4 Alexei Degterev,3,5 Junying Yuan,3 Michael Chorev,2 Jose A. Halperin,2 and Gerhard Wagner1,	4EGI-1	5154300
November-06	High-throughput screening of small molecules for bioactivity and target identification in Caenorhabditis elegans	NATURE PROTOCOLS VOL.1 NO.4 2006 1907	Andrew R Burns1, Trevor C Y Kwok1, Al Howard4, Ed Houston4, Karl Johanson4, Anthony Chan4, Sean R Cutler2, Peter McCourt2,3 & Peter J Roy1,3
November-06	Initiation of Protein Synthesis by Hepatitis C Virus Is Refractory to Reduced eIF2 GTP Met-tRNAi Met Ternary Complex Availability	Molecular Biology of the Cell Vol. 17, 4632–4644, November 2006	Francis Robert,* Lee D. Kapp,† Shakila N. Khan,* Michael G. Acker,† Sarah Kolitz,† Shirin Kazemi,‡ Randal J. Kaufman,§  William C. Merrick,¶ Antonis E. Koromilas,‡ Jon R. Lorsch,† and Jerry Pelletier*#	Salubrinal/Sal003	5147990
October-06	Direct observation of individual endogenous protein complexes in situ by proximity ligation	Nature Methods - 3, 995 - 1000 (2006)	Ola Soederberg 1, 3, Mats Gullberg1, 3, Malin Jarvius1, 3, Karin Ridderstråle2, Karl-Johan Leuchowius1, Jonas Jarvius1, Kenneth Wester1, Per Hydbring2, Fuad Bahram2, Lars-Gunnar Larsson2 & Ulf Landegren1	10058 10074	5404711 5236925
October-06	Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy	NATURE CHEMICAL BIOLOGY VOLUME2 NUMBER10 OCTOBER2006	Karson S Putt1, Grace W Chen2, Jennifer M Pearson2, Joseph S Sandhorst2, Martin S Hoagland3, Jung-Taek Kwon4, Soon-Kyung Hwang4, Hua Jin4, Mona I Churchwell5, Myung-Haing Cho4, Daniel R Doerge5, William G Helferich3 & Paul J Hergenrother1,2	PAC-1	5851625
September-06	Exogenous control of mammalian gene expression via modulation of translational termination	NATURE MEDICINE VOLUME 12  NUMBER 9  SEPTEMBER 2006, 1093	George J Murphy, Gustavo Mostoslavsky, Darrell N Kotton & Richard C Mulligan		5744318 7903053
September-06	Small molecules with antimicrobial activity against E. coli and P. aeruginosa identified by high-throughput screening	British Journal of Pharmacology (2006) 149, 551–559	R De La Fuente1, N D Sonawane1, D Arumainayagam1 and A S Verkman1
September-06	Treatment of Chlamydia trachomatis with a small molecule inhibitor of the Yersinia type III secretion system disrupts progression of the chlamydial developmental cycle	Mol Microbiol. 2006 September; 61(6): 1543–1555.	K. Wolf, H. J. Betts, B. Chellas-Géry, S. Hower, C. N. Linton, and K. A. Fields*	C1 This compound is also known as INP0007 in some publications	5113023
August-06	Thermodynamics of Binding of a Low-Molecular-Weight CD4 Mimetic to HIV-1 gp120	Biochemistry, 45 (36), 10973 -10980, 2006.	Arne Schoen, Navid Madani, Jeffrey C. Klein, Amy Hubicki, Danny Ng, Xinzhen Yang, Amos B. Smith, III, Joseph Sodroski, and Ernesto Freire*	NBD-556 NBD-557	5849968 5857355
July-06	Discovery and characterization of inhibitors of human palmitoyl acyltransferases	Mol Cancer Ther 2006; 5(7): 1647–59	Charles E. Ducker,1 Lindsay K. Griffel,2 Ryan A. Smith,2 Staci N. Keller,1 Yan Zhuang,1 Zuping Xia,3 John D. Diller,4 and Charles D. Smith1,2,3	Compound I Compound III Compound V	5269865 5790443 5657368
July-06	Pemphigus vulgaris identifies plakoglobin as key suppressor of c-Myc in the skin	The EMBO Journal (2006) 25, 3298–3309	Lina Williamson1, Natalia A Raess1, Reto Caldelari1, Anthony Zakher1, Alain de Bruin1, 4, Horst Posthaus1, Reinhard Bolli2, Thomas Hunziker3, Maja M Suter1 and Eliane J Müller1	MI-1 MI-3	5521700 5404711
July-06	Small Molecule Inhibitor of p53 Binding to Mitochondria Protects Mice from Gamma Radiation	Nature Chemical Biology July 2006, 2, 474	E Strom, S Sathe, P Komarov, O Chernova, I Pavlovska, I Shyshynova, D Bosykh, L Burdelya, R Macklis, R Skaliter, E Komarova and A Gudkov	Pifithrin-mu	5147472
July-06	Voltage-Gated K+ Channel Block by Catechol Derivatives: Defining Nonselective and Selective Pharmacophores	Journal of Pharmacology And Experimental Therapeutics  319:758-764, 2006	Vicenta Salvador-Recatala, Yonjung Kim, Elena Zaks-Makhina, and Edwin S. Levitan	48F10	5115671
July-06	Identification of novel antimicrobials using a live animal infection model	PNAS, 103(27), 2006, 10414-10419	T.I. Moy, A.R. Ball, Z. Anklesaria, G. Casadei, K. Lewis & F.M. Ausubel	1                    2                    3                    4                    5                    6                    7                    8                    9                  10                11                12                  13                     14                         15                 16	5113013  5117999   5139008   5140317    5142855   5142992   5143237   5146442   5151562   5189005   5200063   5202043   5248942   5253943   5255640   5260504
July-06	Small molecule screening in the zebrafish	Methods. 2006 Jul;39(3):255-61	Murphey RD, Zon LI
June-06	Dynasore, a Cell-Permeable Inhibitor of Dynamin	Developmental Cell 10, 839–850, June, 2006	Eric Macia,1,2,3 Marcelo Ehrlich,1,2,4 Ramiro Massol,1 Emmanuel Boucrot,1 Christian Brunner,1 and Tomas Kirchhausen1,*	Dynasore	5105472
June-06	Novel Compound 2-Methyl-2H-pyrazole-3-carboxylic Acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) Prevents 2,3,7,8-TCDD-Induced Toxicity by Antagonizing the Aryl Hydrocarbon Receptor	Mol Pharmacol 69:1871–1878, 2006	Sun-Hee Kim, Ellen C. Henry, Dong-Kyu Kim, Yun-Hee Kim, Kum Joo Shin, Myoung Sook Han, Taehoon G. Lee, Jong-Ku Kang, Thomas A. Gasiewicz, Sung Ho Ryu, and Pann-Ghill Suh	CH-223191	5223191
May-06	Identification of TRIO-GEFD1 chemical inhibitors using the yeast exchange assay	Biol. Cell, (2006), 98, 511-522	Anne Blangy, Nathalie Bouquier, Cecile Gauthier-Rouviere, Susanne Schmidt, Anne Debant, Jean-Paul Leonetti & Philippe Fort	NPPD               PEPD               CPEPD	5133201 5215341  5633007
May-06	A small-molecule screen in C. elegans yields a new calcium channel antagonist	Nature 441, 91-95 (4 May 2006)	Trevor C. Y. Kwok1,5, Nicole Ricker1,5, Regina Fraser2, Allen W. Chan4, Andrew Burns1, Elise F. Stanley4, Peter McCourt2,3, Sean R. Cutler2 & Peter J. Roy1,3	Nemadipine-A	5619779
April-06	Antitumor Activity of Sphingosine Kinase Inhibitors	THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Vol. 318, No. 2 2006	Kevin J. French, John J. Upson, Staci N. Keller, Yan Zhuang, Jong K. Yun, and Charles D. Smith	SKI I SKI II	5784220 5663543
April-06	Biochemical suppression of small molecule inhibitors: a new strategy to identify inhibitor targets and signaling pathway components	Chem Biol. 2006 April; 13(4): 443–452.	Jeffrey R. Peterson,1* Andres M. Lebensohn,2 Henry E. Pelish,3 and Marc W. Kirschner2	Pirl-1	5137877
April-06	Managing, profiling and analyzing a library of 2.6 million compounds gathered from 32 chemical providers	Molecular Diversity (2006), 10, 389-403	A. Monge, A. Alban, C. Marot & L. Morin-Allory
April-06	Structural analysis of metalloform-selective inhibition of methionine aminopeptidase	Acta Cryst. (2006). D62, 425-432	S.-X. Xie, W.-J. Huang, Z.-Q. Ma, M. Huang, R. P. Hanzlik and Q.-Z. Ye		6009336 6281056 5659206
March-06	Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington’s and Parkinson’s diseases	PNAS March 14, 2006 vol. 103 no. 11 4246-4251	Ruth A. Bodner*, Tiago Fleming Outeiro, Stephen Altmann, Michele M. Maxwell, Stephanie H. Cho*, Bradley T. Hyman, Pamela J. McLean, Anne B. Young, David E. Housman*,, and Aleksey G. Kazantsev,	B2 B5	6133799 6238457
March-06	The Cdc42 inhibitor secramine B prevents cAMP-induced K+ conductance in intestinal epithelial cells	Bioochemical pharmacology 71 (2006) 1720 – 1726	Henry E. Pelish a,b, William Ciesla c, Nori Tanaka c, Krishna Reddy c, Matthew D. Shair b, Tomas Kirchhausen a, Wayne I. Lencer c,d,*	Pirl-1	5137877
February-06	Leadlikeness and structural diversity of synthetic screening libraries	Molecular Diversity (2006)	Herman J. Verheij
February-06	Identification of Small Molecules that Sensitize Resistant Tumor Cells to Tumor Necrosis Factor-Family Death Receptors	Cancer Res 2006; 66(4): 2367-75	Aaron D. Schimmer,1,2,3 Michael P. Thomas,1 Rose Hurren,2 Marcela Gronda,2 Maurizio Pellecchia,1 Gregory R. Pond,2 Marina Konopleva,4 Debbie Gurfinkel,2 Imtiaz A. Mawji,2 Ewan Brown,2 and John C. Reed1	Fasentin	5809354 6094911
January-06	Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation	Nature 439, 484-489 (26 January 2006)	Mitsuhiro Watanabe1,6, Sander M. Houten1,6, Chikage Mataki1, Marcelo A. Christoffolete2, Brian W. Kim2, Hiroyuki Sato1, Nadia Messaddeq1, John W. Harney2, Osamu Ezaki3, Tatsuhiko Kodama4, Kristina Schoonjans1, Antonio C. Bianco2 & Johan Auwerx1,5	TGR5 agonist	5569653
January-06	Design and Synthesis of 5-Aryl-pyridone-carboxamides as Inhibitors of Anaplastic Lymphoma Kinase	J. Med. Chem. 2006, 49, 1006-1015	Rongshi Li,*,† Liquan Xue,‡ Tong Zhu,† Qin Jiang,‡ Xiaoli Cui,‡ Zheng Yan,† Danny McGee,† Jian Wang,† Vidyasagar Reddy Gantla,† Jason C. Pickens,† Doug McGrath,† Alexander Chucholowski,† Stephan W. Morris,*,‡ andThomas R. Webb*,†,|
December-05	New Class of Competitive Inhibitor of Bacterial Histidine Kinases	JOURNAL OF BACTERIOLOGY, Dec. 2005, p. 8196–8200 Vol. 187, No. 23	Raymond Gilmour,1 J. Estelle Foster,1† Qin Sheng,1 Jonathan R. McClain,1 Anna Riley,1 Pei-Ming Sun,1 Wai-Leung Ng,2 Dalai Yan,1‡ Thalia I. Nicas,1 Kenneth Henry,1 and Malcolm E. Winkler2*	TEP	5317259
December-05	Small molecules that delay S phase suppress a zebrafish bmyb mutant	Nature Chemical Biology 1, 366 - 370 (2005)	Howard M Stern Ryan D Murphey Jennifer L Shepard James F Amatruda Christian T Straub Kathleen L Pfaff Gerhard Weber John A Tallarico Randall W King & Leonard I Zon	Persynthamide, psy (this cmpd has 2 CBC IDs)	5110170 5111972
November-05	Inhibition of the Calcineurin-NFAT Interaction by Small Organic Molecules Reflects Binding at an Allosteric Site*	THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 280, NO. 45, pp. 37698–37706, November 11, 2005	Sunghyun Kang‡§1,2, Huiming Li‡§2, Anjana Rao‡§, and Patrick G. Hogan‡3	INCA1 INCA2 INCA6 INCA12	5169038 5158552 5100275 5133193
November-05	Small molecules that reactivate p53 in renal cell carcinoma reveal a NF- B-dependent mechanism of p53 suppression in tumors	PNAS   November 29, 2005   vol. 102   no. 48 17448-17453	Katerina V. Gurova*†‡§, Jason E. Hill*‡¶, Canhui Guo*, Anatoly Prokvolit*, Lyudmila G. Burdelya*, Eugenia Samoylova*, Anna V. Khodyakova*, Ram Ganapathi , Mahrukh Ganapathi , Natalia D. Tararova*, Dmitry Bosykh†, Dmitriy Lvovskiy**, Thomas R. Webb**, George R. Stark*§, and Andrei V. Gudkov*†§	30d9 NB this cmpd not found in CBC database. Chloro analogue (for OH) number given for ref purposes	5561661
September-05	Identification of N-phenyl-N′-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4	Virology, 339, Issue 2, September 2005, 213-225	Qian Zhaoa, Liying Maa, Shibo Jiangb, Hong Lub, Shuwen Liub, Yuxian Heb, Nathan Strickc, Nouri Neamatid and Asim Kumar Debnatha	NBD-556 NBD-557	5849968 5857355
September-05	Structure–activity relationship study of novel necroptosis inhibitors	Bioorganic & Medicinal Chemistry Letters 15 (2005) 5039–5044	Xin Teng,a Alexei Degterev,b Prakash Jagtap,a Xuechao Xing,a Sungwoon Choi,a Re´gine Denu,a Junying Yuanb and Gregory D. Cunya,*	Necrostatin-1	5115807
July-05	Chemical Inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury	NATURE CHEMICAL BIOLOGY VOLUME 1 NUMBER 2 JULY 2005	A Degterev, Z Huang, M Boyce, Y Li, P Jagtap, N Mizushima, G Cuny, T Mitchison, MA Moskowitz and J Yuan	Necrostatin-1	5115807
July-05	The small chemical vacuolin-1 alters the morphology of lysosomes without inhibiting Ca2+-regulated exocytosis	EMBO reports VOL 6, NO 9 , 2005 scientificreport scientific report 843-847	Chau Huynh & NormaW. Andrews+	Vacuolin-1	5114069
June-05	Systematic Identification of Antiprion Drugs by High-Throughput Screening Based on Scanning for Intensely Fluorescent Targets	JOURNAL OF VIROLOGY, June 2005, p. 7785–7791	Uwe Bertsch,1 Konstanze F. Winklhofer,2 Thomas Hirschberger,3 Jan Bieschke,1† Petra Weber,1 F. Ulrich Hartl,2 Paul Tavan,3 Jo¨rg Tatzelt,2 Hans A. Kretzschmar,1 and Armin Giese1*	297F03 305E04 309F02 293G02	5260186 5268118 5315106 5326487
May-05	Targeting Tn5 Transposase Identifies Human Immunodeficiency Virus Type 1 Inhibitors	ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, May 2005, p. 2035–2043 Vol. 49, No. 5	Brandon Ason,1† Daniel J. Knauss,2 Allison M. Balke,1 George Merkel,3 Anna Marie Skalka,3 and William S. Reznikoff1*	1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 10-A 10-B 10-C 10-D 10-E 10-F 10-G	6160027 6141194 6140731 6158572 5868253 6075259 5980789 6058083 6229546 6176494 6192779 5546355 5535396 6227564 5233170 5232986 5232985 6046791 6044999 5988232 5789176 6204337 6206397 8065508 6171674 6180772 6215673.
April-05	Malaria Parasites Are Rapidly Killed by Dantrolene Derivatives Specific for the Plasmodial Surface Anion Channel	Mol Pharmacol 68:34-40, 2005	Myungsa Kang, Godfrey Lisk, Stephen Hollingworth, Stephen M. Baylor, and Sanjay A. Desai	NPF-1 NPF-2	6574929 6435597
March-05	The power of chemical genomics to study the link between endomembrane system components and the gravitropic response	PNAS 2005, 102 (13), 4902-4907	Marci Surpin *, Marcela Rojas-Pierce *, Clay Carter * , Glenn R. Hicks *, Jacob Vasquez, and Natasha V. Raikhel	Gravacin is 5850247	5403629 5850247 5271050
February-05	A Selective Inhibitor of eIF2a Dephosphorylation Protects Cells from ER Stress	SCIENCE VOL 307 11 FEBRUARY 2005	Michael Boyce,1 Kevin F. Bryant,2* Ce´line Jousse,3* Kai Long,4* Heather P. Harding,3 Donalyn Scheuner,5 Randal J. Kaufman,5 Dawei Ma,4 Donald M. Coen,2 David Ron,3 Junying Yuan1.	Salubrinal	5147990
February-05	Genetic and chemical analyses of the action mechanisms of sirtinol in Arabidopsis	PNAS 2005, 102 (8), 3129-3134	Xinhua Dai *, Ken-ichiro Hayashi , Hiroshi Nozaki , Youfa Cheng *, and Yunde Zhao *	Sirtinol	5108474
January-05	A potent small molecule inhibits polyglutamine aggregation in Huntington’s disease neurons and suppresses neurodegeneration in vivo	PNAS   January 18, 2005   vol. 102   no. 3  892-7	Xiaoqian Zhang*†, Donna L. Smith†‡, Anatoli B. Meriin*, Sabine Engemann§, Deborah E. Russel¶, Margo Roark , Shetia L. Washington , Michele M. Maxwell¶, J. Lawrence Marsh , Leslie Michels Thompson**††, Erich E. Wanker§, Anne B. Young¶, David E. Housman‡‡, Gillian P. Bates‡, Michael Y. Sherman*, and Aleksey G. Kazantsev¶§§	C2 C2-8	5253122 5210775
January-05	In Vivo Drug Discovery in the Zebrafish	Nature Reviews Drug Discovery 2005, 4, 35-44	Leonard I. Zon* and Randall T. Peterson†
January-05	Identification of mosquito sterol carrier protein-2 inhibitors	Journal of Lipid Research Volume 46, 650, 2005	Min-sik Kim, Vilena Wessely, and Que Lan1	SCPI-1 SCPI-5	5935517 6109229
December-04	The CRM1 Nuclear Export Receptor Controls Pathological Cardiac Gene Expression	MOLECULAR AND CELLULAR BIOLOGY, Dec. 2004, p. 10636–10649	Brooke C. Harrison, Charles R. Roberts, David B. Hood, Meghan Sweeney, Jody M. Gould, Erik W. Bush, and Timothy A. McKinsey*	Compound referenced in: Cancer Cell 4:463–476	5219668
November-04	N-Substituted Pyrrole Derivatives as Novel Human Immunodeficiency Virus Type 1 Entry Inhibitors That Interfere with the gp41 Six-Helix Bundle Formation and Block Virus Fusion	Antimicrobial Agents and Chemotherapy, November 2004, p. 4349-4359, Vol. 48, No. 11	Shibo Jiang,* Hong Lu, Shuwen Liu, Qian Zhao, Yuxian He, and Asim K. Debnath	NB-2 NB-64	5987008 6500658
October-04	Identification of inhibitors of auxin transcriptional activation by means of chemical genetics in Arabidopsis	PNAS   October 12, 2004   vol. 101   no. 41   14979	Joshua I. Armstrong, Shiaulou Yuan, Joseph M. Dale, Vanessa N. Tanner, and Athanasios Theologis*	A B C	5820849 5763562 5961295
October-04	Small-Molecule Inhibitor of Vibrio cholerae Virulence and Intestinal Colonization	sciencexpress.org / 13 October 2004 / Page 1/	Deborah T. Hung,* Elizabeth A. Shakhnovich, Emily Pierson, John J. Mekalanos	Virstatin	5158496
October-04	Metalloform-selective inhibitors of escherichia coli methionine aminopeptidase and X-ray structure of a Mn(II)-form enzyme complexed with an inhibitor	J Am Chem Soc. 2004;126:13940–13941	Ye, QZ; Xie, SX; Huang, M; Huang, WJ; Lu, JP; Ma, ZQ
September-04	Identification of Inhibitors for UDP-Galactopyranose Mutase	J. AM. CHEM. SOC. 2004, 126, 10532-10533 (see also….. J. AM. CHEM. SOC. 2004, 126, 15924 for a structure correction)	Michelle Soltero-Higgin, Erin E. Carlson, John H. Phillips, and Laura L. Kiessling*	Compound 2 Compound 3 Compound 4	6044448 5575573 5847736
September-04	Identification of Novel Small-Molecule Inhibitors of Severe Acute Respiratory Syndrome-Associated Coronavirus by Chemical Genetics	Chemistry & Biology, Vol. 11, 1293–1299, September, 2004,	Richard Y. Kao,1,* Wayne H.W. Tsui,1 Terri S.W. Lee,1 Julian A. Tanner,2 Rory M. Watt,2 Jian-Dong Huang,2 Lihong Hu,3 Guanhua Chen,3 Zhiwei Chen,4 Linqi Zhang,4 Tian He,4 Kwok-Hung Chan,1 Herman Tse,1 Amanda P.C. To,1 Louisa W.Y. Ng,1 Bonnie C.W. Wong,1 Hoi-Wah Tsoi,1 Dan Yang,3 libraries) David D. Ho,4 and Kwok-Yung Yuen1	MP576 HE602 VE607	5763678 6026920 6075949
August-04	Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation	Nat Struct Mol Biol. 2004 Aug;11(8):747-55	Peterson JR, Bickford LC, Morgan D, Kim AS, Ouerfelli O, Kirschner MW, Rosen MK.	Wiskostatin	5236849
August-04	Discovery of a Small Molecule that Inhibits the Interaction of Anthrax Edema Factor with Its Cellular Activator, Calmodulin	Chemistry & Biology, Vol. 11, 1139–1146, August, 2004,	Young-Sam Lee,1,4 Pamela Bergson,2,3,4 Wei Song He,2 Milan Mrksich,1,* and Wei-Jen Tang2,3,*	10506-2A	5935999
August-04	Identification of Novel Parasitic Cysteine Protease Inhibitors Using Virtual Screening. 1. The ChemBridge Database	Journal of Medicinal Chemistry 2004 Dec 16;47(26):6609-15	Prashant V. Desai,† Akshay Patny,† Yogesh Sabnis,† Babu Tekwani,‡ Jiri Gut,§ Philip Rosenthal,§ Anuradha Srivastava,‡ and Mitchell Avery*,†,‡
August-04	Small-molecule-based identification of dynamic assembly of E2F-pocket protein-histone deacetylase complex for telomerase regulation in human cells	PNAS 2004 , 101 (31), 11328-11333	Jaejoon Won , Seungwoo Chang , Sangtaek Oh , , and Tae Kook Kim ,	CGK1026	5217444
August-04	The small chemical vacuolin-1 inhibits Ca2+-dependent lysosomal exocytosis but not cell resealing	EUROPEAN MOLECULAR BIOLOGY ORGANIZATION (EMBO) reports VOL 5  NO 9 2004	Jan Cerny 1,2, Yan Feng3, Anan Yu1, Katsuya Miyake4, Barbara Borgonovo5, Judith Klumperman6, Jacopo Meldolesi 5, Paul L. McNeil4 & Tomas Kirchhausen1,3+	Vacuolin-1	5114069
June-04	Chemical genetics to identify NFAT inhibitors: Potential of targeting calcium mobilization in immunosuppression	PNAS   June 15, 2004   vol. 101   no. 24   8969–8974	Natarajan Venkatesh*, Yan Feng*†, Brian DeDecker†, Patrick Yacono‡, David Golan‡, Timothy Mitchison*†, and Frank McKeon*§	Found 14 interesting cmpds.	5114006 5115555 5115805 5143072 5149521 5190027 5202034 5205327 5211950 5219735 5228195 5232755 5156381 5103885
June-04	Chemical screening by mass spectrometry to identify inhibitors of anthrax lethal factor	Nature Biotechnology 2004, 22 (6), 717-723	Min DH; Tang WJ; Mrksich M	DS-998	5267209
June-04	Small Molecule Regulators of Protein Arginine Methyltransferases*	THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 279, No. 23, Issue of June 4, pp. 23892–23899, 2004	Donghang Cheng‡, Neelu Yadav‡, Randall W. King§, Maurice S. Swanson¶, Edward J. Weinstein **, and Mark T. Bedford‡ ‡‡	AMI-1 AMI-2 AMI-3 AMI-5 AMI-6 AMI-7 AMI-8	5255879 5112759 5255910 5122150 5135283 5141951 5175464
June-04	Sorting inhibitors (Sortins): Chemical compounds to study vacuolar sorting in Arabidopsis	PNAS   June 22, 2004   vol. 101   no. 25   9497–9501	Jan Zouhar, Glenn R. Hicks, and Natasha V. Raikhel*	Sortin 1 Sortin 2	6168516 6239069
June-04	Targeting cell division: Small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality	PNAS   August 10, 2004   vol. 101   no. 32   11821–11826	Danielle N. Margalit*†, Laura Romberg‡§, Rebecca B. Mets¶ , Alan M. Hebert*, Timothy J. Mitchison*‡**, Marc W. Kirschner*‡**, and Debabrata RayChaudhuri¶††	Z1 Z2 Z3 Z4	5175333 5233705 5175327 5141951
May-04	Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK	Oncogene (2004) 23, 4984–4992	Hongbo Zhu1,2, Lidong Zhang1,4, Shuhong Wu1,4, Fuminori Teraishi1, John J Davis1,3, Dietmar Jacob1 and Bingliang Fang1,3	2,3-DCPE 2,3-DCEE	5568781 7018362
May-04	Overcoming the gridlock in discovery research	Nature Biotechnology  22, 522 - 524 (2004)	Jonathan Margolis & Greg D Plowman	GS4012 (this cmpd has 5 CBC Ids depending on salt counterion)	5104010 5104012 5129554 5152061 5152068
April-04	Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation	Nature Biotechnology  22, 595 - 599 (2004)	Randall T Peterson1, Stanley Y Shaw1, 2, Travis A Peterson1, David J Milan1, Tao P Zhong1, 3, Stuart L Schreiber2, Calum A MacRae1 & Mark C Fishman1, 4	GS4012 (this cmpd has 5 CBC IDs depending on salt counterion) GS3999 (this cmpd has 4 CBC IDs depending on salt counterion)	5104010 5104012 5129554 5152061 5152068 5103999 5104016 5152070 5152073
April-04	Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide	Journal of Lipid Research Volume 45, 2004, 1256	Thomas J. F. Nieland,*,†,§ Angeliki Chroni,** Michael L. Fitzgerald, †† Zoltan Maliga, †,§ Vassilis I. Zannis,** Tomas Kirchhausen, † and Monty Krieger1,*	BLT-4	5109586
April-04	Dissection of the Dislocation Pathway for Type I Membrane Proteins with a New Small Molecule Inhibitor, Eeyarestatin	Molecular Biology of the Cell Vol. 15, 1635–1646, April 2004	Edda Fiebiger,* Christian Hirsch,* Jatin M. Vyas,† Eva Gordon,*‡ Hidde L. Ploegh,*§ and Domenico Tortorella*	Eeyarestatin I Eeyarestatin II	5138427 5138490
March-04	A small molecular activator of cardiac hypertrophy uncovered in a chemical screen for modifiers of the calcineurin signaling pathway	PNAS 2004, 101, 2870-2875	Erik Bush * , Jens Fielitz , Lawrence Melvin *, Michael Martinez-Arnold , Timothy A. McKinsey *, Ryan Plichta *, and Eric N. Olson	PAMH	5720858
March-04	Chemical Genetic Screening Identifies Sulfonamides That Raise Organellar pH and Interfere with Membrane Traffic	Traffic 2004; 5: 478–492	Thomas J. F. Nieland1,2, Yan Feng2, Jing Xu Brown3, Tuan Daniel Chuang4, Peter D. Buckett3, Jin Wang5, Xiao-Song Xie5, Timothy E. McGraw4, Tomas Kirchhausen1,2,* and Marianne Wessling-Resnick3,*	6B6 (Exo 1) 15E19 (Exo 2) 16D20 30N12 4F17 16F19 17G7	5150075 5113462 5190839 5175331 5117202 5175496 5111986
February-04	Drug-like Annotation and Duplicate Analysis of a 23-supplier Chemical Database Totalling 2.7 Million Compounds	J Chem Inf Comput Sci., 2004 44 643-651	N Baurin, R Baker, C Richardson, I Chen, N Foloppe, A Potter, A Jordan, S Roughley, M Parratt, P Greaney, D Morley and RE Hubbard
February-04	Induction of Apoptosis and Down-Regulation of Bcl-XL in Cancer Cells by a Novel Small Molecule, 2[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol	Cancer Research 64, 1110-1113, February 1, 2004	Shuhong Wu1, Hongbo Zhu1, Jian Gu2, Lidong Zhang1, Fuminori Teraishi1, John J. Davis1,3, Dietmar A. Jacob1 and Bingliang Fang1,3	2,3-DCPE 2,3-DCEE	5568781 7018363
January-04	Novel Neuroprotective K+ Channel Inhibitor Identified by High-Throughput Screening in Yeast	Mol Pharmacol 65:214-219, 2004	Elena Zaks-Makhina, Yonjung Kim, Elias Aizenman, and Edwin S. Levitan	48F10	5115671
January-04	Cyclohexyl-octahydro-pyrrolo[1,2-a]pyrazine-Based Inhibitors of Human N-Myristoyltransferase-1	THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Vol. 309, No. 1, 340–347, 2004	Kevin J. French,1 Yan Zhuang, Randy S. Schrecengost, Jean E. Copper, Zuping Xia,1 and Charles D. Smith	COPP-2: COPP-15 COPP-19 COPP-24	5782522 5782601 5782553 5782537
December-03	A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells	CANCER CELL : DECEMBER 2003 · 463	Tweeny R. Kau,1,4 Frank Schroeder,6 Shivapriya Ramaswamy,3,5 Cheryl L. Wojciechowski,1,4 Jean J. Zhao,2,4 Thomas M. Roberts,2,4 Jon Clardy,1 William R. Sellers,3,5,* and Pamela A. Silver1,4,*	Found 19 interesting cmpds.  The most potent export inhibitor's ID is given	5219668
September-03	Discovery and Evaluation of Inhibitors of Human Sphingosine Kinase	CANCER RESEARCH 63, 5962–5969, September 15, 2003	Kevin J. French, Randy S. Schrecengost, Brian D. Lee, Yan Zhuang, Staci N. Smith, Justin L. Eberly, Jong K. Yun, and Charles D. Smith2	Cmpd I Cmpd II Cmpd III Cmpd IV NB  Cmpd II is now sold by Calbiochem (2008)	5784220 5663543 5679119 5318164
September-03	Solid-Phase Synthesis of Tetrahydro-1,4-benzodiazepine-2-one Derivatives as a beta-Turn Peptidomimetic Library	J. Comb. Chem. 2004, 6, 207-213	Isak Im,† Thomas R. Webb,‡ Young-Dae Gong,§ Jae-Il Kim,† and Yong-Chul Kim*,†
August-03	Application of a Novel Design Paradigm to Generate General Nonpeptide Combinatorial Scaffolds Mimicking Beta Turns: Synthesis of Ligands for Somatostatin Receptors	Bioorganic & Medicinal Chemistry (2003) 5059-5068	Dona Chianelli, Yong-Chul Kim, Dmitriy Lvovskiy and Thomas R. Webb
July-03	Sir2 Regulates Skeletal Muscle Differentiation as a Potential Sensor of the Redox State	Molecular Cell, Vol. 12, 51–62, July, 2003,	Marcella Fulco,1 R. Louis Schiltz,1 Simona Iezzi,1 M. Todd King,2 Po Zhao,3 Yoshihiro Kashiwaya,2 Eric Hoffman,3 Richard L. Veech,2 and Vittorio Sartorelli1,*	Sirtinol M15	5108474 5104559
May-03	Exo1: A new chemical inhibitor of the exocytic pathway	PNAS 2003, 100 (11), 6469	Yan Feng * , Sidney Yu , Troy K. R. Lasell , Ashutosh P. Jadhav * ¶, Eric Macia ¶ ||, Pierre Chardin ||, Paul Melancon , Michael Roth , Timothy Mitchison *, and Tomas Kirchhausen * ¶	Exo1	5150075
May-03	Identification of a Compound That Directly Stimulates Phospholipase C Activity	Mol Pharmacol Vol. 63, Issue 5, 1043-1050, May 2003	Yoe-Sik Bae, Taehoon G. Lee, Jun Chul Park, Jung Ho Hur, Youndong Kim, Kyun Heo, Jong-Young Kwak, Pann-Ghill Suh, and Sung Ho Ryu	m-3M3FBS	5152047
May-03	Chemical Genetic Modifier Screens: Small Molecule Trichostatin Suppressors as Probes of Intracellular Histone and Tubulin Acetylation	Chemistry & Biology, Vol. 10, 397–410, May, 2003	Kathryn M. Koeller,1,3 Stephen J. Haggarty,1,2,3 Brian D. Perkins,2 Igor Leykin,5 Jason C. Wong,1,3 Ming-Chih J. Kao,5 and Stuart L. Schreiber1,2,3,4,6	ITSA1 ITSA2 ITSA3 ITSA4 ITSA5 nITSA1-A nITSA1-B	5253409 5233705 5149715 5140203 5248896 5273682 5286656
April-03	Low molecular weight inhibitors of Myc–Max interaction and function	Oncogene (2003) 22, 6151–6159	Xiaoying Yin1, Christine Giap1, John S Lazo2,3, Edward V Prochownik*,1,3,4	10009-G9 10050-C10 10058-F4 10074-A4	5561686 5154282 5404711 5236925
April-03	Multiherbicide Tolerance conferred by AtPgp1 and apyrase overexpression in Arabidopsis thaliana	Nature Biology Vol 21 April 2003	Brian Windsor, Stanley J Roux and Alan Lloyd	NGXT 191	5253067
March-03	Targeting Bacterial Virulence Inhibitors of Type III Secretion in Yersinia	Chemistry & Biology, 10 (2003) 241-249.	Anna M. Kauppi1, 3, Roland Nordfelth2, 3, Hanna Uvell2, Hans Wolf-Watz2 and Mikael Elofsson	Compound 2 Compound 4 Compound 2 is also known as INP0007 in some publications	5113023 5175374
January-03	Identification of Small-Molecule Inhibitors of Human Angiogenin and Characterization of Their Binding Interactions Guided by Computational Docking	Biochemistry 2003, 42, 6674-6687	Jeremy L. Jenkins‡ and Robert Shapiro*,‡,§	C-181431 C-473872 C-467929	5181431 5473872 5467929
January-03	Virtual screening to enrich hit lists from high-throughput screening: a case study on small-molecule inhibitors of angiogenin	Proteins. 2003 Jan 1;50(1):81-93	Jenkins JL, Kao RY, Shapiro R.
December-02	Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin–induced intestinal fluid secretion	J. Clin. Invest. 110(11): 1651-1658 (2002).	Tonghui Ma1, Jay R. Thiagarajah1, Hong Yang1, Nitin D. Sonawane1, Chiara Folli2, Luis J.V. Galietta2 and A.S. Verkman1	CFTRinh-172	6078358
November-02	Automated Colorimetric Screen for Apyrase Inhibitors	BioTechniques 33:1024-1030 2002	J.B. Windsor, C. Thomas, L. Hurley1, S.J. Roux, and A.M. Lloyd	NGXT 195 NGXT 199 NGXT 1913	5113723 5210410 5211072
November-02	Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI	PNAS   November 26, 2002   vol. 99   no. 24 15422-15427	Thomas J. F. Nieland*†, Marsha Penman†, Limor Dori†, Monty Krieger†‡§, and Tomas Kirchhausen*‡§	BLT-1 BLT-2 BLT-3 BLT-4 BLT-5	5234221 5234225 5106931 5109586 5117098
November-02	Quinazolines as Adenosine Receptor Antagonists: SAR and Selectivity for A2B Receptors	Bioorganic & Medicinal Chemistry 11 (2003) 77-85	TR Webb, D Lvovskiy, S-A Kim, W-d Ji, N Melman, J Linden and KA Jacobson	CMB 6446	5306446
October-02	High-affinity Activators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Conductance Identified by High-throughput Screening	The Journal of Biological Chemistry 2002 , 277 (40), 37235-37241	Tonghui Ma, L. Vetrivel, Hong Yang, Nicoletta Pedemonte§, Olga Zegarra-Moran§, Luis J. V. Galietta§, and A. S. Verkman¶	CFTact-02 CFTact-04 CFTact-06 CFTact-07 CFTact-08 CFTact-09 CFTact-11 CFTact-12 CFTact-13 CFTact-15 CFTact-16 CFTact-17	6042112 5738519 5972686 5936587 5773709 6043758 5101039 6142416 5218287 5966451 6143156 5312649
October-02	Small molecule modulation of Smoothened activity	PNAS October 29, 2002 vol. 99 no. 22 14071-14076	James K. Chen, Jussi Taipale, Keith E. Young, Tapan Maiti, and Philip A. Beachy *	SANT-1 SANT-2 SANT-3 SANT-4	5786262 5800831 5725940 5568598
July-02	A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity	PNAS July 23, 2002 vol. 99 no. 15 10066-10071	Richard Y. T. Kao*,, Jeremy L. Jenkins*, Karen A. Olson*,, Marc E. Key§, James W. Fett*,, and Robert Shapiro*,,¶
June-02	High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated Tp53-responsive luciferase reporter	Carcinogenesis, Vol. 23, No. 6, 949-958, June 2002	Taylor A. Sohn1, Ravi Bansal3, Gloria H. Su2,3, Kathleen M. Murphy2 and Scott E. Kern2,4
January-02	A small-molecule inhibitor of skeletal muscle myosin II.	Nature Cell Biology 4, 83 - 88 (2001)	Cheung, A., J.A. Dantzig, S. Hollingworth, S.M. Baylor, Y.E. Goldman, T.J. Mitchison, and A.F. Straight.	Compound 1 (BTS) Compound 2 Compound 4	5116373 5253736 5102862
November-01	Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoprotein	PNAS   November 20, 2001   vol. 98   no. 24 14078-14083	Roman V. Kondratov*†, Pavel G. Komarov‡, Yigal Becker‡, Ariel Ewenson‡, and Andrei V. Gudkov*§	QB102	6130863
October-01	Convergence of distinct pathways to heart patterning revealed by the small molecule concentramide and the mutation heart-and-soul	Current Biology Volume 11, Issue 19, 2 October 2001, Pages 1481-1491	Randall T. Peterson, John D. Mably, Jau-Nian Chena and Mark C. Fishman	Concentramide	5243294
October-01	Identification of a Class of Small Molecule Inhibitors of the Sirtuin Family of NAD-dependent Deacetylases by Phenotypic Screening	J. Biol. Chem. 2001 , 276 (42), 38837	Grozinger, C. M.; Chao, E.D.; Blackwell, H.E.; Moazed, D.; Schreiber, S. L.	Sirtinol M15	5108474 5104559
October-01	Use of isogenic human cancer cells for high-throughput screening and drug discovery	Nature Biotechnology  19, 940 - 945 (2001)	Christopher J. Torrance, Vijai Agrawal, Bert Vogelstein & Kenneth W. Kinzler	SC-D TPT	5141565 5252916
May-01	High-Throughput Drug Screening of the DPC4 Tumor-Suppressor Pathway in Human Pancreatic Cancer Cells	Annals of Surgery. 233(5):696-703, May 2001.	Sohn, Taylor A. MD *; Su, Gloria H. PhD +; Ryu, Byungwoo PhD ++; Yeo, Charles J. MD *++; Kern, Scott E. MD ++	Scriptaid	5158497
February-01	Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL	NATURE CELL BIOLOGY VOL 3 FEBRUARY 2001	Alexei Degterev*†‡, Alexey Lugovskoy§¶‡, Michael Cardone#, Bradley Mulley*, Gerhard Wagner§, Timothy Mitchison*† and Junying Yuan*,**	BH3I-1 BH3I-1' BH3I-2	5275805 5282986 5175362
November-00	Small molecule developmental screens reveal the logic and timing of vertebrate development	PNAS November 21, 2000 vol. 97 no. 24 12965-12969	Randall T. Peterson*,, Brian A. Link, John E. Dowling, and Stuart L. Schreiber*,,,§,¶	32N8 33M20 32N5 31J6 32P6 31B4 33N14 31N3	5175083 5234221 5150905 5266239 5243294 5101231 5251609 5138859
June-00	A Novel Histone Deacetylase Inhibitor Identified by High-throughput Transcriptional Screening of a Compound Library	Cancer Res. 2000 , 60, 3137-42	Su, G.H.; Taylor, A.S.; Byungwoo, R.; Kern, S.E.	Scriptaid	5158497
June-00	Signaling Pathways to the Assembly of an Interferon- Enhanceosome. CHEMICAL GENETIC STUDIES WITH A SMALL MOLECULE	J. Biol. Chem. 2000 , 275, 16910-17	Taeil Kim, Tae Young Kim, Woo Ghil Lee§, Jeongbin Yim, and Tae Kook Kim§¶	CG-18	5112719
January-00	The utilization of a unified pharmacophore query in the discovery of new antagonists of the adenosine receptor family	Bioorganic and Medicinal Chemistry Letters, Volume 10, Number 1, 3 January 2000 , pp. 31-34(4)	Webb T.R.T.R.1; Melman N.N.; Lvovskiy D.D.; Ji X.X.-d.; Jacobson K.A.K.A
October-99	Multiple Novel Inhibitors of the NorA Multidrug Transporter of Staphylococcus aureus	Antimicrobial Agents and Chemotherapy 1999 , 43, 2404-08	Penelope N. Markham,1,* Eric Westhaus,1 Katya Klyachko,2 Michael E. Johnson,2 and Alex A. Neyfakh2	INF 55 INF 240 INF 271 INF 277 INF 392	5107950 5187143 5109586 5213684 5241292
October-99	Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-based Screen.	Science 1999 , 286, 971-74.	Mayer, T. U.; Kapoor, T.M.; Haggarty, S.J.; King, R.W.; Screiber, S.L.; Mitchison, T. J.	Monastrol	5322014
September-99	A Chemical Inhibitor of p53 that Protects Mice from the Side Effects of Cancer Therapy	Science 1999 , 285, 1733-37	Pavel G. Komarov, 1,2* Elena A. Komarova, 1* Roman V. Kondratov, 1,5 Konstantin Christov-Tselkov, 3 John S. Coon, 2 Mikhail V. Chernov, 4 Andrei V. Gudkov 1	PFT-alpha (Pifithrin-alpha)	5120841
June-99	Chemical Genetic and Genomic Approaches Reveal a Role for Copper in Specific Gene Activation	J. Am. Chem. Soc.; 1999; 121(45) pp 10662 - 10663	Brent R. Stockwell, James S. Hardwick, Jeffrey K. Tong, and Stuart L. Schreiber	Cmpd 1b Cmpd 1c Cmpd 2	5175091 5175093 5112930