ChemBridge's combinatorial libraries are designed and produced in-house, and explore pharmacophore space using proprietary building blocks and unpublished scaffolds. This leads to libraries that provide our clients with novel, small molecules with improved IP potential.
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NOVACore Library |
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PHARMACophore Library |
These libraries offer many advantages including:
Novelty – 150 medicinally relevant scaffolds have been produced over a period of 8 years. Independent analysis comparing against a 4.8M structure database found <30 matches with final compounds.
Diversity - These libraries are designed by selection from virtual databases based on the following criteria: low final compound numbers per template, use of computational 2D/3D similarity and diversity filters, with many relevant chemical classes represented. Divergent design and use of templates with multiple points of substitution further insure diversity of our libraries.
Built-in SAR - Each scheme within a library contains sub-sets of related compounds that
provide a readily available, cost-effective source of compounds for SAR studies. Related
compounds can be included in initial screens to generate early SAR information or
accessed after hit generation to extend SAR.
Ease of Follow Up - Flexible follow-up options include:
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100% availability for all hit re-supply |
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Access to key precursor intermediates & relevant synthetic protocols |
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Synthesis of exclusive sub-libraries for SAR and hit to lead work. |
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