 |
Kravchenko, J. E.; Ilyinskaya, G. V.; Komarov, P. G.; Agapova, L. S.; Kochetkov, D. V.; Strom, E.; Frolova, E. I.; Kovriga, I.; Gudkov, A. V.; Feinstein, E.; Chumakov, P. M.; Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. PNAS 2008, 105 (17), 6302-6307. |
|
Sadek, H.; Hannack, B.; Choe, E.; Wang, E.; Latif, S.; Garry, M. G.; Garry, D. J.; Longgood, J.; Frantz, D. E.; Olson, E. N.; Hsieh, J.; Schneider, J. W.; Cardiogenic small molecules that enhance myocardial repair by stem cells. PNAS 2008, 105 (16), 6063-6068. |
|
Neugebauer, R. C.; Uchiechowska, U.; Meier, R.; Hruby, H.; Valkov, V.; Verdin, E.; Sippl, W.; Jung, M.; Structure-Activity Studies on Splitomicin Derivatives as Sirtuin Inhibitors and Computational Prediction of Binding Mode. J. Med Chem. 2008, 51, 1203-1213. |
|
Dupré, A.; Boyer-Chatenet, L.; Sattler, R. M.; Modi, A. P.; Lee, J.; Nicolette, M. L.; Kopelovich, L.; Jasin, M.; Baer, R.; Paull, T. T.; Gautier, J.; A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nature Chem. Bio. 2008, 4 (2), 119-125. |
|
Kostka, M.; Högen, T.; Danzer, K. M.; Levin, J.; Habeck, M.; Wirth, A.; Wagner, R.; Glabe, C. G.; Finger, S.; Heinzelmann, U.; Garidel, P.; Duan, W.; Ross, C. A.; Kretzschmar, H.; Giese, A.; Single-particle characterization of iron-induced pore-forming α-synuclein oligomers. J. of Bio. Chem. 2008. |
|
Montes, M.; Braud, E.; Miteva, M. A.; Goddard, M.; Mondésert, O.; Kolb, S.; Brun, M.; Ducommun, B.; Garbay, C.; Villoutreix, B. O.; Receptor-Based Virtual Ligand Screening for the Identification of Novel CDC25 Phosphatase Inhibitors. J. Chem. Inf. Model. 2008, 48, 157-165. |
|
Herschhorn, A.; Oz-Gleenberg, I.; Hizi, A.; Mechanism of Inhibition of HIV-1 Reverse Transcriptase by the Novel Broad-Range DNA Polymerase Inhibitor N-{2-[4-(Aminosulfonyl)phenyl]ethyl}-2-(2-thienyl)acetamide.; Biochemistry 2008, 47, 490-502. |
|
Yang, Y.; Kitagaki, J.; Dai, R.; Tsai, Y. C.; Lorick, K. L.; Ludwig, R. L.; Pierre, S. A.; Jensen, J. P.; Davydov, I. V.; Oberoi, P.; Li, C. H.; Kenten, J. H.; Beutler, J. A.; Vousden, K. H.; Weissman, A. M.; Inhibitors of Ubiquitin-Activating Enzyme (E1), a New Class of Potential Cancer Therapeutics. Cancer Res. 2007, 67 (19), 9472-9481. |
|
Richardson, R. D.; Smith, J. W.; Novel antagonists of the thioesterase domain of human fatty acid synthase.; Mol Cancer Ther. 2007, 6 (7), 2120- 2126. |
|
Hirayama, K.; Aoki, S.; Nishikawa, K.; Matsumoto, T.; Wada, K.; Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening. Bioorg. Med. Chem. 2007, 15, 6810-6818. |
|
Huang, M.; Xie, S.; Ma, Z.; Huang, Q.; Nan, F.; Ye, Q.; Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis.; J. Med. Chem. 2007, 50, 5735-5742. |
|
McNamara, C. R.; Mandel-Brehm, J.; Bautista, D. M.; Siemens, J.; Deranian, K. L.; Zhao, M.; Hayward, N. J.; Chong, J. A.; Julius, D.; Moran, M. M.; Fanger, C. M.; TRPA1 mediates formalin-induced pain. PNAS 2007, 104 (33), 13525-13530. |
|
Lemaire, G.; Benod, C.; Nahoum, V.; Pillon, A.; Boussioux, A.; Guichou, J.; Subra, G.; Pascussi, J.; Bourguet, W.; Chavanieu, A.; Balaguer, P.; Discovery of a Highly Active Ligand of Human Pregnane X Receptor: A Case Study from Pharmacophore Modeling and Virtual Screening to "In Vivo" Biological Activity. Mol Pharm 2007, 72 (3), 572-581. |
|
Vidal, D.; Blobel, J.; Pérez, Y.; Thormann, M.; Pons, M.; Structure-based discovery of new small molecule inhibitors of low molecular weight protein tyrosine phosphatase. Eur. J. of Med. Chem. 2007, 42, 1-7. |
|
Viaud, J.; Zeghouf, M.; Barelli, H.; Zeeh, J.; Padilla, A.; Guibert, B.; Chardin, P.; Royer, C. A.; Cherfils, J.; Chavanieu, A.; Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes. PNAS 2007, 104 (25), 10370-10375. |
|
Roman, D. L.; Talbot, J. N.; Roof, R. A.; Sunahara, R. K.; Traynor, J. R.; Neubig, R. R.; Identification of Small-Molecule Inhibitors of RGS4 Using a High-Throughput Flow Cytometry Protein Interaction Assay. Mol. Pharmacol. 2007, 71 (1), 169-175. |
|
Putt, K. S.; Chen, G. W.; Pearson, J. M.; Sandhorst, J. S.; Hoagland, M. S.; Kwon, J.; Hwang, S.; Jin, H.; Churchwell, M. I.; Cho, M.; Doerge, D. R.; Helferich, W. G.; Hergenrother, P. J.; Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nature Chem. Bio. 2006, 2 (10), 543-550. |
|
Ducker, C. E.; Griffel, L. K.; Smith, R. A.; Keller, S. N.; Zhuang, Y.; Xia, Z.; Diller, J. D.; Smith, C. D.; Discovery and characterization of inhibitors of human palmitoyl acyltransferases. Mol. Cancer Ther. 2006, 5 (7), 1647-1659. |
|
Strom, E.; Sathe, S.; Komarov, P. G.; Chernova, O. B.; Pavlovska, I.; Shyshynova, I.; Bosykh, D. A.; Burdelya, L. G.; Macklis, R. M.; Skaliter, R.; Komarova, E. A.; Gudkov, A. V.; Small-molecule inhibitor p53 binding to mitochondria protects mice from gamma radiation. Nature Chem. Bio. 2006. |
|
Verheij, H. J.; Leadlikeness and structural diversity of synthetic screening libraries. Mol. Diversity 2006, 10 (3), 377-388. |
|
Robert, F.; Kapp, L. D.; Khan, S. N.; Acker, M. G.; Kolitz, S.; Kazemi, S.; Kaufman, R. J.; Merrick, W. C.; Koromilas, A. E.; Lorsch, J. R.; Pelletier, J.; Initiation of Protein Synthesis by Hepatitis C Virus is Refractory to Reduced eIF2 · GTP · Met-tRNAiMet Ternary Complex Availability. Mol. Biol. Cell. 2006, 17, 4632-4644. |
|
Macia, E.; Ehrlich, M.; Massol, R.; Boucrot, E.; Brunner, C.; Kirchhausen, T.; Dynasore, a Cell-Permeable Inhibitor of Dynamin. Dev. Cell. 2006, 10 (6), 839-850. |
|
Gilmour, R.; Foster, J. E.; Sheng, Q.; McClain, J. R.; Riley, A.; Sun, P.; Ng, W.; Yan, D.; Nicas, T. I.; Henry, K.; Winkler, M. E.; New Class of Competitive Inhibitor of Bacterial Histidine Kinases. J. of Bacteriology 2005, 187 (23), 8196-8200. |
|
Gurova, K. V.; Hill, J. E.; Guo, C.; Prokvolit, A.; Burdelya, L. G.; Samoylova, E.; Khodyakova, A. V.; Ganapathi, R.; Ganapathi, M.; Tararova, N. D.; Bosykh, D.; Lvovskiy, D.; Webb, T. R.; Stark, G. R.; Gudkov, A. V.; Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kB-dependent mechanism of p53 suppression in tumors. PNAS 2005, 102 (48), 17448-17453. |
|
Kang, S.; Li, H.; Rao, A.; Hogan, P. G.; Inhibition of the Calcineurin-NFAT Interaction by Small Organic Molecules Reflects Binding at an Allosteric Site. J. of Biological Chemistry 2005, 280 (45), 37698-37706. |
|
Hung, D. T.; Shakhnovich, E. A.; Pierson, E.; Mekalanos, J. J.; Small-Molecule Inhibitor of Vibrio Cholerae Virulence and Intestinal Colonization. Science 2005, 310, 670-674. |
|
Ason, B.; Knauss, D. J.; Balke, A. M.; Merkel, G.; Skalka, A.; Reznikoff, W. S.; Targeting Tn5 Transposase Identifies Human Immunodeficiency Virus Type 1 Inhibitors. Antimicrobial Agents and Chemotherapy 2005, 49 (5), 2035-2043. |
|
Surpin, M.; Rojas-Pierce, M.; Carter, C.; Hicks, G. R.; Vasquez, J.; Raikhel, N. V.; The power of chemical genomics to study the link between endomembrane system components and the gravitropic response. PNAS 2005, 102 (13), 4902-4907. |
|
Huynh, C.; Andrews, N. W.; The small chemical vacuolin-1 alters the morphology of lysomes without inhibiting Ca²+-regulated exocytosis. EMBO 2005, 6 (9), 843-847. |
|
Degterev, A.; Huang, Z.; Boyce, M.; Li, Y.; Jagtap, P.; Mizushima, N.; Cuny, G. D.; Mitchison, T. J.; Moskowitz, M. A.; Yuan, J.; Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nature Chem. Bio. 2005, 1 (2), 112-119. |
|
Dai, X.; Hayashi, K.; Nozaki, H.; Cheng, Y.; Zhao, Y.; Genetic and chemical analyses of the action mechanisms of sirtinol in Arabidopsis. PNAS 2005, 102 (8), 3129-3134. |
|
Zhang, X.; Smith, D. L.; Meriin, A. B.; Engemann, S.; Russel, D. E.; Roark, M.; Washington, S. L.; Maxwell, M. M.; Marsh, J. L.; Thompson, L. M.; Wanker, E. E.; Young, A. B.; Housman, D. E.; Bates, G. P.; Sherman, M. Y.; Kazantsev, A. G.; A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo. PNAS 2005 , 102 (3), 892-897. |
|
Boyce, M.; Bryant, K. F.; Jousse, C.; Long, K.; Harding, H. P.; Scheuner, D.; Kaufman, R. J.; Ma, D.; Coen, D. M.; Ron, D.; Yuan, J; A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress. Science 2005, 307, 935-939. |
|
Zon, L. I.; Peterson, R. T.; In Vivo Drug Discovery in the Zebrafish. Nature Reviews Drug Discovery 2005, 4, 35-44. |
|
Desai, P. V.; Patny, A.; Sabnis, Y.; Tekwani, B.; Gut, J.; Rosenthal, P.; Srivastava, A.; Avery, M.; Identification of Novel Parasitic Cysteine Protease Inhibitors Using Virtual Screening. 1. The ChemBridge Database. Journal of Medicinal Chemistry 2004, 47 (26), 6609-6615. |
|
Fiebiger, E.; Hirsch, C.; Vyas, J. M.; Gordon, E.; Ploegh, H. L.; Tortorella, D.; Dissection of the Dislocation Pathway for Type I Membrane Proteins with a New Small Molecule Inhibitor, Eeyarestatin. Molecular Biology of the Cell 2004, 15, 1635-1646. |
|
Harrison, B. C.; Roberts, C. R.; Hood, D. B.; Sweeney, M.; Gould, J. M.; Bush, E. W.; McKinsey, T. A.; The CRM1 Nuclear Export Receptor Controls Pathological Cardiac Gene Expression. Molecular and Cellular Biology 2004, 24 (24), 10636-10649. |
|
Min, D.; Tan, W.; Mrksich, M.; Chemical Screening by mass spectrometry to identify inhibitors of anthrax lethal factor. Nature Biotechnology 2004, 22 (6), 717-723. |
|
Peterson, R.T.; Shaw, S. Y.; Peterson, T. A.; Milan, D. J.; Zhong, T. P.; Schreiber, S. L.; MacRae, C. A.; Fishman, M. C.; Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nature Biotechnology 2004, 22 (5), 595-599. |
|
Kao, R. Y.; Tsui, W. H.W.; Lee, T. S.W.; Tanner, J. A.; Watt, R. M.; Huang, J.; Hu, L.; Chen, G.; Chen, Z.; Zhang, L.; He, T.; Chan, K.; Tse, H.; To, A. P.C.; Ng, L. W.Y.; Wong, B. C.W.; Tsoi, H.; Yang, D.; Ho, D. D.; Yuen, K.; Identification of Novel Small-Molecule Inhibitors of Severe Acute Respiratory Syndrome-Associated Coronavirus by Chemical Genetics. Chemistry & Biology 2004, 11, 1293-1299. |
|
Lee, Y.; Bergson, P.; He, W. S.; Mrksich, M.; Tang, W.; Discovery of a Small Molecule that Inhibits the Interaction of Anthrax Edema Factor with Its Cellular Activator, Calmodulin. Chemistry & Biology 2004, 11, 1139-1146. |
|
Armstrong, J. I.; Yuan, S.; Dale, J. M.; Tanner, V. N.; Theologis, A.; Identification of inhibitors of auxin transcriptional activation by means of chemical genetics in Arabidopsis. PNAS 2004, 101 (41), 14978-14983. |
|
Margalit, D. N.; Romberg, L.; Mets, R. B.; Hebert, A. M.; Mitchison, T. J.; Kirschner, M. W.; RayChaudhuri, D.; Targeting cell division: Small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. PNAS 2004, 101 (32), 11821-11826. |
|
Nieland, T. J. F.; Feng, Y.; Brown, J. X.; Chuang, T. D.; Buckett, P. D.; Wang, J.; Xie, X.; McGraw, T. E.; Kirchhausen, T.; Wessling-Resnick, M.; Chemical Genetic Screening Identifies Sulfonamides That Raise Organellar pH and Interfere with Membrane Traffic. Traffic 2004, 5, 478-492. |
|
Won, J.; Chang, S.; Oh, S.; Kim, T. K.; Small-molecule-based identification of dynamic assembly of E2F-pocket protein-histone deacetylase complex for telomerase regulation in human cells. PNAS 2004 , 101 (31), 11328-11333. |
|
Venkatesh, N.; Feng, Y.; DeDecker, B.; Yacono, P.; Golan, D.; Mitchison, T.; McKeon, F.; Chemical genetics to identify NFAT inhibitors: Potential of targeting calcium mobilization in immunosuppression. PNAS 2004 , 101 (24), 8969-8974. |
|
Cerny, J.; Feng, Y.; Yu, A.; Miyake, K.; Borgonovo, B.; Klumperman, J.; Meldolesi, J.; McNeil, P. L.; Kirchhausen, T.; The small chemical vacuolin-1 inhibits Ca²+-dependent lysosomal exocytosis but not cell resealing. EMBO 2004, 5 (9), 883-888. |
|
Cheng, D.; Yadav, N.; King, R. W.; Swanson, M. S.; Weinstein, E. J.; Bedford, M. T.; Small Molecule Regulators of Protein Arginine Methyltransferases. Journal of Biological Chemistry 2004, 279 (23), 23892-23899. |
|
Zouhar, J.; Hicks, G. R.; Raikhel, N. V.; Sorting inhibitors (Sortins): Chemical compounds to study vacuolar sorting in Arabidopsis. PNAS 2004, 101 (25), 9497-9501. |
|
Bush, E.; Fielitz, J.; Melvin, L.; Martinez-Arnold, M.; McKinsey, T. A.; Plichta, R.; Olson, E. N.; A small molecular activity of cardiac hypertrophy uncovered in a chemical screen for modifiers of the calcineurin signaling pathway. PNAS 2004, 101, 2870-2875. |
|
Baurin, N.; Baker, R.; Richardson, C.; Chen, I.; Foloppe, N.; Potter, A.; Jordan, A.; Roughley, S.; Parratt, M.; Greaney, P.; Morley, D.; Hubbard, R.E.; Drug-like Annotation and Duplicate Analysis of a 23-Supplier Chemical Database Totalling 2.7 Million Compounds. J. Chem. Inf. Comput. Sci. 2004 , 44, 643-651. |
|
Koller, K. M.; Haggarty, S. J.; Perkins, B. D.; Leykin, I.; Wong, J. C.; Ming-Chih, J. K.; Schreiber, S. L.; Chemical Genetic Modifier Screens: Small Molecule Trichostatin Suppressors as Probes of Intracellular Histone and Tubulin Acetylation. Chemistry & Biology 2003 , 10, 397-410. |
|
French, K.J.; Schrecengost, R.S.; Lee, B.D.; Zhuang, Y.; Smith, S.N.; Eberly, J.L.; Yun, J.K.; Smith, C.D.; Discovery and Evaluation of Inhibitors of Human Sphingosine Kinase. Cancer Research 2003 , 63, 5962-5969. |
|
Fulco, M.; Schlitz, R. L.; Iezzi, S.; King, M. T.; Zhao, P.; Kashiwaya, Y.; Hoffman, E.; Veech, R. L.; Sartorelli, V.; Sir2 Regulates Skeletal Muscle Differentiation as a Potential Sensor of the Redox State. Molecular Cell 2003 , 12, 51-62. |
|
Jenkins, J. L.; Shapiro, R.; Identification of Small-Molecule Inhibitors of Human Angiogenin and Characterization of Their Binding Interactions Guided by Computational Docking. Biochemistry 2003 , 42, 6674-6687. |
|
Yin, X.; Giap, C.; Lazo, J. S.; Prochownik, E. V.; Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene 2003 , 22, 6151-6159. |
|
Bae, Y.; Lee, T. G.; Park, J. C.; Hur, J. H.; Kim, Y.; Heo, K.; Kwak, J.; Suh, P.; Ryu, S. H.; Identification of a Compound That Directly Stimulates Phospholipase C Activity. Molecular Pharmacology 2003 , 63, 1043-1050. |
|
Feng, Y.; Yu, S.; Lasell, T. K. R.; Jadhav, A. P.; Macia, E.; Chardin, P.; Melancon, P.; Roth, M.; Mitchison, T.; Kirchhausen, T.; Exo1: A new chemical inhibitor of the exocytic pathway. PNAS 2003, 100 (11), 6469-6474. |
|
Windsor, B.; Roux, S. J.; Lloyd, A.; Multiherbicide tolerance conferred by AtPgp1 and apyrase overexpression in Arabidopsis thaliana. Nature Biotechnology 2003 , 21, 428-433. |
|
Webb, T. R.; Lvovskiy, D.; Kim, S. A.; Ji, X.; Melman, N.; Linden, J.; Jacobson, K. A.; Quinazolines as Adenosine Receptor Antagonists: SAR and Selectivity for A(2B) Receptors. Bioorganic & Medicinal Chemistry 2003 , 11 (1), 77-85. |
|
Jenkins, J. L.; Kao, R. Y.; Shapiro, R.; Virtual Screening to Enrich Hit Lists from High-Throughput Screening: A Case Study on Small-Molecule Inhibitors of Angiogenin. Proteins: Structure, Function, and Genetics 2003 , 50 (1), 81-93. |
|
Ma, T.; Thiagarajah, J. R.; Yang, H.; Sonawane, N. D.; Folli, C.; Galietta, L. J. V.; Verkman, A. S.; Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. The Journal of Clinical Investigation 2002 , 110 (11), 1651-1658. |
|
Nieland, T. J. F.; Penman, M.; Dori, L.; Krieger, M.; Kirchhausen, T.; Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI. PNAS 2002 , 99 (24), 15422-15427. |
|
Windsor, J. B.; Thomas, C.; Hurley, L.; Roux, S.J.; Lloyd, A.M.; Automated Colorimetric Screen for Apyrase Inhibitors. BioTechniques 2002 , 33, 1024-1030. |
|
Chen, J. K.; Taipale, J.; Young, K. E.; Maiti, T.; Beachy, P. A.; Small molecule modulation of Smoothened activity. PNAS 2002 , 99 (22), 14071-14076. |
|
Ma, T.; Vetrivel, L.; Yang, H.; Pedemonte, N.; Zegarra-Moran, O.; Galietta, L. J. V.; Verkman, A. S.; High-affinity Activators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Conductance Identified by High-throughput Screening. The Journal of Biological Chemistry 2002 , 277 (40), 37235-37241. |
|
Kao, R. Y. T.; Jenkins, J. L.; Olson, K. A.; Key, M. E.; Fett, J. W.; Shapiro, R.; A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity. PNAS 2002 , 99 (15), 10066-71. |
|
Sohn, T. A.; Bansal, R.; Su, G. H.; Murphy, K. M.; Kern, S. E.; High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated. Carcinogenesis 2002 , 23 (6), 949-957. |
|
Cheung, A.; Dantzig, J. A.; Hollingworth, S.; Baylor, S. M.; Goldman, Y.E.; Mitchison, T. J.; Straight, A. F. A small-molecule inhibitor of skeletal muscle myosin II. Nature Cell Biology 2002 , 4, 83-84. |
|
Kondratov, R.V.; Komarov, P.G.; Becker, Y.; Ewenson, A.; Gudkov, A. Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoprotein. PNAS 2001 , 98 (24), 14078-83. |
|
Peterson, R.T.; Mably, J.D.; Chen, J.; Fishman, M. C. Convergence of distinct pathways to heart patterning revealed by the small molecule concentramide and the mutation heart-and-soul. Current Biology 2001 , 11, 1481-1491. |
|
Torrance, C.J.; Agrawal, V.; Vogelstein, B.; Kinzler, K. W. Use of Isogenic Human Cancers Cells for High-throughput Screening and Drug Discovery. Nature Biotechnology 2001 , 19, 940-945. |
|
Sohn, T. A.; Su, G. H.; Ryu, B.; Yeo, C. J.; Kern, S. E.; High-Throughput Drug Screening of the DPC4 Tumor-Suppressor Pathway in Human Pancreatic Cancer Cells. Annals of Surgery 2001 , 233 (5), 696-703. |
|
Grozinger, C. M.; Chao, E.D.; Blackwell, H.E.; Moazed, D.; Schreiber, S. L. Identification of a Class of Small Molecule Inhibitors of the Sirtuin Family of NAD-dependent Deacetylases by Phenotypic Screening. J. Bio. Chem. 2001 , 276 (42), 38837. |
|
Degterev, A.; Lugovskoy, A.; Cardone, M.; Mulley, B.; Wagner, G.; Mitchison, T.; Yuan, J. Identification of Small-Molecule Inhibitors of Interaction between the BH3 Domain and Bcl-xL. Nature Cell Biology 2001 , 3, 173-82. |
|
Peterson, R.; Link, B.A.; Dowling, J.E.; Schreiber, S. L. Small Molecule Developmental Screens Reveal the Logic and Timing of Vertebrate Development. PNAS 2000 , 97, 12965-69. |
|
Kim, T.; Kim, T.Y.; Lee, W.G.; Yim, J.; Kim; T.K.. Signaling Pathways to the Assembly of an Interferon-B Enhanceosome. J. Biol. Chem. 2000 , 275, 16910-17. |
|
Su, G.H.; Taylor, A.S.; Byungwoo, R.; Kern, S.E. A Novel Histone Deacetylase Inhibitor Identified by High-throughput Transcriptional Screening of a Compound Library. Cancer Res. 2000 , 60, 3137-42. |
|
Webb, T. R.; Melman, N.; Lvovskiy, D.; Ji, X.; Jacobson, K. A. The Utilization of a Unified Pharmacophore Query in the Discovery of New Antagonists of the Adenosine Receptor Family. Bioorg. Med. Chem. Lett. 2000 , 10, 31-34. |
|
Mayer, T. U.; Kapoor, T.M.; Haggarty, S.J.; King, R.W.; Screiber, S.L.; Mitchison, T. J. Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-based Screen. Science 1999 , 286, 971-74. |
|
Komarov, P. G.; Komarova, E. A.; Kondratov, R. V.; Christov-Tselkov, K.; Coon, J. S.; Chernov, M. V.; Gudkov, A. V. A Chemical Inhibitor of p53 that Protects Mice from the Side Effects of Cancer Therapy. Science 1999 , 285, 1733-37. |
|
Markham, P.N.; Westhaus, E.; Klyachko, K.; Johnson, M.E.; Neyfakh, A. A. Multiple Novel Inhibitors of the NorA Multidrug Transporter of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 1999 , 43, 2404-08. |
|
Stockwell, B.R.; Hardwick, J.S.; Tong, J.K.; Schreiber, S. L. Chemical genetic and genomic approaches reveal a role for copper in specific gene activation. J. of Amer. Chem. Society 1999 , 121, 10662-10663. |
top of the page |
