Targeted Libraries

ChemBridge Corporation offers a cutting-edge research platform for GPCR and Kinase focused drug discovery that can fulfill expectations in terms of biologically focused pharmacophore diversity, structural novelty, drug-relevant design, chemical purity, and rapid hit-to-lead support.

Target library offerings include:

• GPCR Library
• Kinase Library

GPCR Library, representing 14,000 compounds based on 9 templates, using the following principals:

	Mimicking GPCR-ligand interaction phenomena via a rational design approach.
	Application of rigorous novelty criteria.
	High quality assurance, 80% of the library is over 95% pure by NMR, LCMS-ELSD.
	Designed to enable rapid hit-to-lead optimization.

Our GPCR targeted library has led to:

	Drug discovery advancements by several independent laboratories.
	Successful identification of both agonists and antagonists.
	Implementation of tractable synthetic chemistry exemplified by quick follow-up in medicinal chemistry services.

KINACore (kinase targeted library) representing approximately 3,900 compounds selected from over 40 unique templates:

	A computationally selected collection of novel compounds utilizing a ligand-based pharmacophore selection method.
	Application of rigorous novelty criteria.
	This selection method and the library have been validated in silico as well as by in vitro Kinase inhibition screening.
	Robust and versatile chemistry with synthons, protocols, and expertise accessible, including scaling up.

KINACore has led to:

	Successful collaboration with a major US clinical oncology center, with compounds in lead optimization.
	Approach yielded selective kinase inhibitors.
	Implementation of tractable synthetic chemistry exemplified by quick follow-up in medicinal chemistry services.

For more information about our targeted libraries, contact sales@chembridge.com.

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