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New Research Cites ChemBridge Screening Compounds and Libraries

San Diego, CA, USA, May 27, 2015

During January through March 2015, more than 30 articles were published that cite the use of ChemBridge small molecule screening compounds or small molecule libraries. The articles cover a wide range of different research areas - a sampling is provided below.

To search the more than 1,200 articles that cite ChemBridge compounds or libraries, visit our Search Page and select to run a Published Compound / Scientific Article search.

  • A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication, Nature Medicine , PMID 25751815
  • Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels, Proceedings of the National Academy of Sciences, PMID 25733897
  • Discovery of InhA inhibitors with anti-mycobacterial activity through a matched molecular pair approach, European Journal of Medicinal Chemistry, PMID 25778993
  • Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar, Blood, PMID 25587041
  • Cellular chirality arising from the self-organization of the actin cytoskeleton, Nature Cell Biology, PMID 25799062
  • T cell lipid peroxidation induces ferroptosis and prevents immunity to infection, Journal of Experimental Medicine, PMID 25824823
  • Antiviral activities of 15 dengue NS2B-NS3 protease inhibitors 5 using a human cell-based viral quantification assay, Antiviral Research, PMID 25823617
  • Estrogen receptor alpha inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression, Proceedings of the National Academy of Sciences, PMID 25825714
  • (+)-Borneol alleviates mechanical hyperalgesia in models of chronic inflammatory and neuropathic pain in mice, European Journal of Pharmacology, PMID
  • Fingerprint-based consensus virtual screening towards structurally new 5-HT6R ligands, Bioorganic and Medicinal Chemistry Letters, PMID
  • Evaluation of spiropiperidine hydantoins as a novel class of antimalarial agents, Bioorganic and Medicinal Chemistry Journal, PMID 25797165
  • Thiazolidine-2,4-dione Derivatives: Programmed Chemical Weapons for Key Protein Targets of Various Pathological Conditions, Bioorganic and Medicinal Chemistry Journal, PMID
  • Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation, Blood, PMID 25742700
  • Morphine causes persistent induction of nitrated neurofilaments in cortex and subcortex even during abstinence., Neuroscience, PMID 25684749
  • PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation, Cell Reports , PMID 25660020
  • Selection-based discovery of macrocyclic peptides for the next generation therapeutics, Current Opinion in Chemical Biology , PMID 25703142
  • A Novel System for Xylem Cell Differentiation in Arabidopsis thaliana, Molecular Plant , PMID 25624147
  • Inhibition of Anopheles gambiae Odorant Receptor Function by Mosquito Repellents, Journal of Biological Chemistry, PMID 25657000
  • Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria, Nature Chemical Biology, PMID 25686372
  • An early secretory pathway mediated by GNOM-LIKE 1 and GNOM is essential for basal polarity establishment in Arabidopsis thaliana, Proceedings of the National Academy of Sciences, PMID 25646449
  • Ex vivo inhibition of Clostridium botulinum neurotoxin types B, C, E, and F by small molecular weight inhibitors, Toxicon, PMID 25707753
  • Discovery of Small Molecule Inhibitors to Kruppel-like Factor 10 (KLF10): Implications for Modulation of T Regulatory Cell Differentiation, Journal of Medicinal Chemistry, PMID 25581017
  • Modulation of a Pore in the Capsid of JC Polyomavirus Reduces Infectivity and Prevents Exposure of the Minor Capsid Proteins, Journal of Virology , PMID 25609820
  • Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors, Chemico-Biological Interactions, PMID 25641190
  • Novel Scaffold Fingerprint (SFP): Applications in Scaffold Hopping and Scaffold-Based Selection of Diverse Compounds, Journal of Chemical Information and Modeling, PMID 25558803
  • The Apoptotic Mechanism of Action of the Sphingosine Kinase 1 Selective Inhibitor SKI-178 in Human Acute Myeloid Leukemia Cell Liness, Journal of Pharmacology and Experimental Therapeutics, PMID 25563902
  • Discovery of Small Molecule CD40-TRAF6 Inhibitors, Journal of Chemical Information and Modeling, PMID 25622654
  • Discovery of novel antagonists of glycoprotein IIb/IIIa-mediated platelet aggregation through virtual screening, Bioorganic and Medicinal Chemistry Letters, PMID 25677660
  • Aldehyde dehydrogenase-independent bioactivation of nitroglycerin in porcine and bovine blood vessels, Biochemical Pharmacology, PMID 25576686
  • Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters, Biochimica et Biophysica Acta, PMID 25613743
  • Development of an ESI-LC-MS-Based Assay for Kinetic Evaluation of Mycobacterium tuberculosis Shikimate Kinase Activity and Inhibition, Analytical Chemistry, PMID 25629762

For information on ChemBridge's screening compounds and libraries, please contact your ChemBridge representative or contact us at

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