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2003-2004 Research Articles Citing ChemBridge

Below is a partial list of articles citing the use of ChemBridge libraries and compounds. The list is updated as additional articles are identified. The PMID value can be used to link to the record at the PubMed website.

• Novel Neuroprotective K+ Channel Inhibitor Identified by High-Throughput Screening in Yeast. Molecular Pharmacology 2004. PMID 14722253
• Cyclohexyl-octahydro-pyrrolo[1,2-a]pyrazine-Based Inhibitors of Human N-Myristoyltransferase-1. Journal of Pharmacology and Experimental Therapeutics 2004. PMID 14724220
• Prevention of toxin-induced intestinal ion and fluid secretion by a small-molecule CFTR inhibitor. Gastroenterology 2004. PMID 14762788
• Dissection of the Dislocation Pathway for Type I Membrane Proteins with a New Small Molecule Inhibitor, Eeyarestatin. Molecular Biology of the Cell 2004. PMID 14767067
• Inhibitors of Protein Synthesis Identified by a High Throughput Multiplexed Translation Screen. Nucleic Acids Research 2004. PMID 14769948
• Induction of Apoptosis and Down-Regulation of Bcl-XL in Cancer Cells by a Novel Small Molecule, 2[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol . Cancer Research 2004. PMID 14871845
• A small molecular activator of cardiac hypertrophy uncovered in a chemical screen for modifiers of the calcineurin signaling pathway. Proceedings of the National Academy of Sciences 2004. PMID 14976250
• Solid-Phase Synthesis of Tetrahydro-1,4-benzodiazepine-2-one Derivatives as a beta-Turn Peptidomimetic Library. Journal of Combinatorial Chemistry 2004. PMID 15002968
• Compound decomposition: a new drug discovery tool?. Drug Discovery Today 2004. PMID 15012928
• Drug-like Annotation and Duplicate Analysis of a 23-supplier Chemical Database Totalling 2.7 Million Compounds. Journal of Chemical Information and Computer Sciences 2004. PMID 15032546
• A Novel Small-Molecule Inhibitor of the Chromosome Segregation Process in Yeast. Other 2004. PMID 15042357
• Small Molecule Regulators of Protein Arginine Methyltransferases. The Journal of Biological Chemistry 2004. PMID 15056663
• Going global in R&D. EMBO Reports 2004. PMID 15060565
• Design and synthesis of Rho kinase inhibitors (I). Bioorganic and Medicinal Chemistry Journal 2004. PMID 15080913
• Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nature Biotechnology 2004. PMID 15097998
• Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide. Journal of Lipid Research 2004. PMID 15102890
• Targeting FOXO Kills Two Birds with One Stone. Chemistry and Biology 2004. PMID 15112990
• Overcoming the gridlock in discovery research. Nature Biotechnology 2004. PMID 15122288
• Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK. Oncogene 2004. PMID 15122344
• A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii . Proceedings of the National Academy of Sciences 2004. PMID 15123807
• Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules . Proceedings of the National Academy of Sciences 2004. PMID 15131267
• Chemical screening by mass spectrometry to identify inhibitors of anthrax lethal factor. Nature Biotechnology 2004. PMID 15146199
• Outsourcing lead optimisation - the quiet revolution. Drug Discovery Today 2004. PMID 15149625
• Virtual Screening for SARS-CoV Protease Based on KZ7088 Pharmacophore Points. Journal of Chemical Information and Computer Sciences 2004. PMID 15154780
• Identification of a Small Molecule that Inhibits Herpes Simplex Virus DNA Polymerase Subunit Interactions and Viral replication. Chemistry and Biology 2004. PMID 15157875
• Discovery and Evaluation of Potent P1 Aryl Heterocycle-Based Thrombin Inhibitors. Journal of Medicinal Chemistry 2004. PMID 15163182
• Drug Identification Through in Vivo Screening of Chemical Libraries. ChemBioChem 2004. PMID 15174173
• Thienopyridine and benzofuran derivatives as potent anti-tumor agents possessing different structure-activity relationships.. Bioorganic and Medicinal Chemistry Letters 2004. PMID 15177443
• Chemical Genetic Screening Identifies Sulfonamides That Raise Organellar pH and Interfere with Membrane Traffic. Traffic 2004. PMID 15180825
• Natural products and combinatorial chemistry: back to the future. Current Opinion in Chemical Biology 2004. PMID 15183325
• Chemical genetics to identify NFAT inhibitors: Potential of targeting calcium mobilization in immunosuppression. Proceedings of the National Academy of Sciences 2004. PMID 15184684
• Sorting inhibitors (Sortins): Chemical compounds to study vacuolar sorting in Arabidopsis. Proceedings of the National Academy of Sciences 2004. PMID 15190181
• Synthesis of Benzoylpyrimidines as Antagonists of the Corticotropin-Releasing factor-1 Receptor. Bioorganic and Medicinal Chemistry Letters 2004. PMID 15225687
• Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nature Structural and Molecular Biology 2004. PMID 15235593
• Small-molecule-based identification of dynamic assembly of E2F-pocket protein-histone deacetylase complex for telomerase regulation in human cells. Proceedings of the National Academy of Sciences 2004. PMID 15263087
• A Virtual Screening Approach to Finding Novel and Potent Antagonists at the Melanin-Concentrating Hormone 1 Receptor. Journal of Medicinal Chemistry 2004. PMID 15267235
• Targeting cell division: Small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. Proceedings of the National Academy of Sciences 2004. PMID 15289600
• Novel asymmetric approach to proline-derived spiro-beta-lactams.. Journal of Organic Chemistry 2004. PMID 15307755
• Discovery of a Small Molecule that Inhibits the Interaction of Anthrax Edema Factor with Its Cellular Activator, Calmodulin. Chemistry and Biology 2004. PMID 15324815
• Identification of Inhibitors for UDP-Galactopyranose Mutase. Journal of the American Chemical Society 2004. PMID 15327298
• The small chemical vacuolin-1 inhibits Ca2+-dependent lysosomal exocytosis but not cell resealing. EMBO Reports 2004. PMID 15332114
• Identification of Novel Small-Molecule Inhibitors of Severe Acute Respiratory Syndrome-Associated Coronavirus by Chemical Genetics. Chemistry and Biology 2004. PMID 15380189
• Identification and Characterization of Small Molecule Inhibitors of the Calcium-Dependent S100B-p53 Tumor Suppressor Interaction. Journal of Medicinal Chemistry 2004. PMID 15456252
• Identification of inhibitors of auxin transcriptional activation by means of chemical genetics in Arabidopsis. Proceedings of the National Academy of Sciences 2004. PMID 15466695
• Disruption of Protein-Membrane Binding and Identification of Small-Molecule Inhibitors of Coagulation Factor VIII. Chemistry and Biology 2004. PMID 15489168
• Characterization of SARS-CoV main protease and identification of biologically active small molecule inhibitors using a continuous fluorescence-based assay. FEBS Letters 2004. PMID 15498556
• N-Substituted Pyrrole Derivatives as Novel Human Immunodeficiency Virus Type 1 Entry Inhibitors That Interfere with the gp41 Six-Helix Bundle Formation and Block Virus Fusion. Antimicrobial Agents and Chemotherapy 2004. PMID 15504864
• Metalloform-selective inhibitors of escherichia coli methionine aminopeptidase and X-ray structure of a Mn(II)-form enzyme complexed with an inhibitor. Journal of the American Chemical Society 2004. PMID 15506752
• Gradient elution of organic acids on a beta-cyclodextrin column in the polar organic mode and its application to drug discovery. Journal of Chromatography 2004. PMID 15527122
• Induction of reversible hemolytic anemia in living zebrafish using a novel small molecule. Comparative Biochemistry and Physiology 2004. PMID 15533782
• Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips . Proceedings of the National Academy of Sciences 2004. PMID 15539461
• Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors. Bioorganic and Medicinal Chemistry Letters 2004. PMID 15546732
• Indoprofen Upregulates the Survival Motor Neuron Protein through a Cyclooxygenase-Independent Mechanism. Chemistry and Biology 2004. PMID 15555999
• A Flexible Data Analysis Tool for Chemical Genetic Screens. Chemistry and Biology 2004. PMID 15556000
• Discovery of 4-Aryl-4H-chromenes as a New Series of Apoptosis Inducers Using a Cell- and Caspase-based High-Throughput Screening Assay. 1. Structure-Activity Relationships of the 4-Aryl Group. Journal of Medicinal Chemistry 2004. PMID 15566300
• The CRM1 Nuclear Export Receptor Controls Pathological Cardiac Gene Expression. Molecular and Cellular Biology 2004. PMID 15572669
• Promises and challenges of targeting Bcl-2 anti-apoptotic proteins for cancer therapy. Biochimica et Biophysica Acta 2004. PMID 15585172
• Design and Synthesis of a Potent and Selective Peptidomimetic Inhibitor of Caspase-3. Journal of Medicinal Chemistry 2004. PMID 15588079
• Identification of Novel Parasitic Cysteine Protease Inhibitors Using Virtual Screening. 1. The ChemBridge Database. Journal of Medicinal Chemistry 2004. PMID 15588096
• Discovery and Use of Small Molecules for Probing Biological Processes in Zebrafish. Methods in Cell Biology 2004. PMID 15602893
• Discovery of Small-Molecule Inhibitors of the NFAT-Calcineurin Interaction by Competitive High-Throughput Fluorescence Polarization Screening.. Biochemistry 2004. PMID 15610001
• Assay for Ubiquitin Ligase Activity: High-Throughput Screen for Inhibitors of HDM2. Journal of Biomolecular Screening 2004. PMID 15634796
• Synthesis of a new tricyclic 3-(tetrazol-5-yl)pyridine system from 2-(azidomethyl)nicotinonitriles. Tetrahedron Letters 2004. PMID N/A
• A convenient synthesis of substituted 3-bromotetrahydrofurans from homoallylic alcohols. Tetrahedron Letters 2004. PMID N/A
• High-throughput screening at McMaster University: automation in academe. Journal of the Association for Laboratory Automation 2004. PMID N/A
• A High-affinity Activator of G551D-CFTR Chloride Channel Identified By High Throughput Screening*. Chemical Research in Chinese Universities 2004. PMID N/A
• Microwave-assisted synthesis of sterically hindered 3-(5-tetrazolyl)pyridines. Tetrahedron Letters 2004. PMID N/A
• One-pot syntheses of 6-mercaptopurines (6MP) from 4,5-diamino-6-chloro-pyrimidines. Tetrahedron Letters 2004. PMID N/A
• Structure and photochromism of 2-(N-acyl-N-arylaminomethylene)benzo[b]thiophen-3(2H)-ones. Other 2004. PMID
• Chemical Properties of 1,6-Polymethylene-5-cyano-1,3,2Lambda5-Diazaphosphinane-2,4-Dithiones Synthesized Via Reactions of Enamines with P2S5/Pyridine System. Other 2004. PMID
• Some Principles Related to Chemogenomics in Compound Library and Template Design for GPCRs. Book Chapter 2004. PMID
• Synthesis of versatile intermediates of the ferrocene series: reductive amination of ferrocenecarbaldehyde. Other 2004. PMID
• Cyanuric and Thiocyanuric Acid Esters: New Carriers of Boron-Containing Molecular Fragments. Other 2004. PMID
• Formylation of 6-Aminouracil with Vilsmeier Reagent. Other 2004. PMID
• Quinazolines as Adenosine Receptor Antagonists: SAR and Selectivity for A2B Receptors. Bioorganic and Medicinal Chemistry Journal 2003. PMID 12467710
• Virtual screening to enrich hit lists from high-throughput screening: a case study on small-molecule inhibitors of angiogenin. Protein Journal (formerly Journal of Protein Chemistry) 2003. PMID 12471601
• Property Distributions: Differences between Drugs, Natural Products, and Molecules from Combinatorial Chemistry. Journal of Chemical Information and Computer Sciences 2003. PMID 12546556
• Forward chemical genetics: progress and obstacles on the path to a new pharmacopoeia. Current Opinion in Chemical Biology 2003. PMID 12547432
• Multiherbicide Tolerance conferred by AtPgp1 and apyrase overexpression in Arabidopsis thaliana. Nature Biology 2003. PMID 12640467
• Targeting Bacterial Virulence: Inhibitors of Type III Secretion in Yersinia . Chemistry and Biology 2003. PMID 12670538
• Identification of a Compound That Directly Stimulates Phospholipase C Activity. Molecular Pharmacology 2003. PMID 12695532
• Structure-based Identification of Binding Sites, Native Ligands and Potential Inhibitors for G-protein Coupled Receptors. Other 2003. PMID 12696053
• Exo1: A new chemical inhibitor of the exocytic pathway. Proceedings of the National Academy of Sciences 2003. PMID 12738886
• Exo1: A new chemical inhibitor of the exocytic pathway . Proceedings of the National Academy of Sciences 2003. PMID 12738886
• Use of Recursion Forests in the Sequential Screening Process: Consensus Selection by Multiple Recursion Trees. Journal of Chemical Information and Computer Sciences 2003. PMID 12767153
• Chemical Genetic Modifier Screens: Small Molecule Trichostatin Suppressors as Probes of Intracellular Histone and Tubulin Acetylation. Chemistry and Biology 2003. PMID 12770822
• Discovery of Substituted N-Phenyl Nicotinamides as Potent Inducers of Apoptosis Using a Cell- and Caspase-Based High Throughput Screening Assay. Journal of Medicinal Chemistry 2003. PMID 12773051
• Discovering Novel Anticancer Drugs: Practical Aspects and Recent Advances. Other 2003. PMID 12777744
• Isolation of p53 Inhibitors by Screening Chemical Libraries in Cell-Based Readout System. Book Chapter 2003. PMID 12777754
• Identification of Small-Molecule Inhibitors of Human Angiogenin and Characterization of Their Binding Interactions Guided by Computational Docking. Biochemistry 2003. PMID 12779322
• Computer-Aided Selection of Potential Antihypertensive Compounds with Dual Mechanism of Action. Journal of Medicinal Chemistry 2003. PMID 12852763
• Evaluation of an Imaging Platform During the Development of a FRET Protease Assay. Journal of Biomolecular Screening 2003. PMID 12855000
• Identification of Latent Hits in Compound Screening Collections.. Journal of Medicinal Chemistry 2003. PMID 12877579
• A Small Inhibitor of the Interaction Between Bax and Bcl-X(L) Can Synergize With Methylprednisolone to Induce Apoptosis in Bcl-X(L)-overexpressing Breast-Cancer Cells. Other 2003. PMID 12884026
• Recent advances in the development of anticancer agents targeting cell death inhibitors in the Bcl-2 protein family.. Leukemia 2003. PMID 12886234
• Sir2 Regulates Skeletal Muscle Differentiation as a Potential Sensor of the Redox State. Molecular Cell 2003. PMID 12887892
• Chemical Genomic Profiling of Biological Networks Using Graph Theory and Combinations of Small Molecule Perturbations. Journal of the American Chemical Society 2003. PMID 12940736
• Discovery, Characterization, and Structure-Activity Relationships Studies of Proapoptotic Polyphenols Targeting B-Cell Lymphocyte/Leukemia-2 Proteins. Journal of Medicinal Chemistry 2003. PMID 13678404
• Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene 2003. PMID 13679853
• Biological Mechanism Profiling Using an Annotated Compound Library. Chemistry and Biology 2003. PMID 14522058
• Discovery and Evaluation of Inhibitors of Human Sphingosine Kinase. Cancer Research 2003. PMID 14522923
• Screening in Academe: A Perspective on Implementation of University-Based Small Molecule Screening. Journal of Biomolecular Screening 2003. PMID 14567789
• Application of a Novel Design Paradigm to Generate General Nonpeptide Combinatorial Scaffolds Mimicking Beta Turns: Synthesis of Ligands for Somatostatin Receptors. Bioorganic and Medicinal Chemistry Journal 2003. PMID 14604669
• Small Molecule Modulation of the Human Chromatid Decatenation Checkpoint. Chemistry and Biology 2003. PMID 14700634
• A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell 2003. PMID 14706338
• 3‐Nitrocoumarin Amidines: A New Synthetic Strategy for Substituted [1]Benzopyrano[3,4‐d ]imidazol‐4(3H )‐ones. European Journal of Organic Chemistry 2003. PMID
• Front Matter. Book Chapter 2003. PMID
• Tautomeric Equilibria and Rearrangements Involving Phenols. Book Chapter 2003. PMID
• Intramolecular Thermal Condensation of 3-Acetyl-5-Oxopyrazolo[1,5-a]quinoline-4-ethylcarboxylate: a Simple Pathway to the New Tetracyclic System Containing Fluoroquinolone Fragment. Other 2003. PMID
• New Conversions and Functionalization Possibilities in Pyrimido[4,5-e][1,2,4]triazine-6,8-diones. Other 2003. PMID
• Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation . Proceedings of the National Academy of Sciences 2003. PMID
• Abstracts for QSAR related Pulications. Other 2003. PMID