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2007-2008 Research Articles Citing ChemBridge

Below is a partial list of articles citing the use of ChemBridge libraries and compounds. The list is updated as additional articles are identified. The PMID value can be used to link to the record at the PubMed website.

  • Development of anaplastic lymphoma kinase (ALK) small-molecule inhibitors for cancer therapy.. Medicinal Research Reviews 2008. PMID 17694547
  • High-throughput screen for small molecules that modulate the ATPase activity of the molecular chaperone DnaK. Analytical Biochemistry 2008. PMID 17904512
  • Novel Lipoxygenase Inhibitors as Neuroprotective Reagents. Journal of Neuroscience Research 2008. PMID 17960827
  • Inhibition of human parainfluenza virus type 3 infection by novel small molecules. Antiviral Research 2008. PMID 17964670
  • Identification of novel inhibitors of bacterial surface enzyme Staphylococcus aureus Sortase A. Bioorganic and Medicinal Chemistry Journal 2008. PMID 18023345
  • Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nature Chemical Biology 2008. PMID 18026094
  • Virtual screening approaches for the identification of non-lipid autotaxin inhibitors. Bioorganic and Medicinal Chemistry Journal 2008. PMID 18036821
  • Mechanism of Inhibition of HIV-1 Reverse Transcriptase by the Novel Broad-Range DNA Polymerase Inhibitor N-{2-[4-(Aminosulfonyl)phenyl]ethyl}-2-(2-thienyl)acetamide. Biochemistry 2008. PMID 18052256
  • An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nature Chemical Biology 2008. PMID 18059262
  • Lessons Learnt From Assembling Screening Libraries for Drug Discovery for Neglected Diseases. ChemMedChem 2008. PMID 18064617
  • In silico screening and biological evaluation of inhibitors of Src-SH3 domain interaction with a proline-rich ligand. Bioorganic and Medicinal Chemistry Letters 2008. PMID 18083027
  • Small-molecule dissection of BMP signaling. Nature Chemical Biology 2008. PMID 18084273
  • Receptor-Based Virtual Ligand Screening for the Identification of Novel CDC25 Phosphatase Inhibitors. Journal of Chemical Information and Modeling 2008. PMID 18154280
  • A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nature Chemical Biology 2008. PMID 18176557
  • Identification of cellular pathways affected by Sortin2, a synthetic compound that affects protein targeting to the vacuole in Saccharomyces cerevisiae. BMC Chemical Biology 2008. PMID 18179719
  • Domain requirement of moenomycin binding to bifunctional transglycosylases and development of high-throughput discovery of antibiotics . Proceedings of the National Academy of Sciences 2008. PMID 18182485
  • A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death. Cell Death and Differentiation 2008. PMID 18188169
  • Novel paradigms for drug discovery: computational multitarget screening. Trends in Pharmacological Sciences 2008. PMID 18190973
  • Inhibition of p97-dependent Protein Degradation by Eeyarestatin I. The Journal of Biological Chemistry 2008. PMID 18199748
  • Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Molecular Cancer Therapeutics 2008. PMID 18202014
  • A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors. European Journal of Medicinal Chemistry 2008. PMID 18207285
  • A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression. Analytical Biochemistry 2008. PMID 18211814
  • Single Particle Characterization of Iron-induced Pore-forming -Synuclein Oligomers. Journal of Biological Chemistry 2008. PMID 18258594
  • Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP-3. The FASEB Journal 2008. PMID 18267983
  • Structure Activity Studies on Splitomicin Derivatives as Sirtuin Inhibitors and Computational Prediction of Binding Mode. Journal of Medicinal Chemistry 2008. PMID 18269226
  • Small-molecule inhibitors of sodium iodide symporter function. ChemBioChem 2008. PMID 18307189
  • Generation of New Synthetic Scaffolds Using Framework Libraries Selected and Refined via Medicinal Chemist Synthetic Expertise. Journal of Chemical Information and Modeling 2008. PMID 18335978
  • A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPAR and PPAR activities. Molecular Cancer Therapeutics 2008. PMID 18347139
  • Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells. Chemistry and Biology 2008. PMID 18355723
  • A Virtual Screen for Diverse Ligands: Discovery of Selective G Protein-Coupled Receptor Antagonists. Journal of the American Chemical Society 2008. PMID 18357984
  • Identification of Promiscuous Small Molecule Activators in High-Throughput Enzyme Activation Screens. Journal of Medicinal Chemistry 2008. PMID 18366176
  • A Poke in the Eye: Inhibiting HIV-1 Protease Through Its Flap-Recognition Pocket. Other 2008. PMID 18381626
  • Identification of a Novel Retinoid by Small Molecule Screening with Zebrafish Embryos. Public Library of Science 2008. PMID 18398471
  • MS-DOCK: Accurate multiple conformation generator and rigid docking protocol for multi-step virtual ligand screening. BMC Bioinformatics 2008. PMID 18402678
  • SAR and QSAR study on 2-aminothiazole derivatives, modulators of transcriptional repression in Huntington\'s disease. Bioorganic and Medicinal Chemistry Journal 2008. PMID 18406155
  • Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis. Methods in Enzymology 2008. PMID 18413242
  • Cardiogenic small molecules that enhance myocardial repair by stem cells. Proceedings of the National Academy of Sciences 2008. PMID 18420817
  • Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proceedings of the National Academy of Sciences 2008. PMID 18424558
  • Changes in PSAC Reduce Leupeptin Uptake and Can Confer Drug Resistance in P. falciparum-Infected Erythrocytes. Antimicrobial Agents and Chemotherapy 2008. PMID 18443109
  • Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Research 2008. PMID 18451142
  • Identification of Genetic and Chemical Modulators of Zebrafish Mechanosensory Hair Cell Death. PLoS Genetics 2008. PMID 18454195
  • Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator. Cancer Cell 2008. PMID 18455128
  • Discovery of Novel Human Histamine H4 Receptor Ligands by Large-Scale Structure-Based Virtual Screening. Journal of Medicinal Chemistry 2008. PMID 18459760
  • Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery. Bioorganic and Medicinal Chemistry Journal 2008. PMID 18462943
  • A Genetic Screen for Dihydropyridine (DHP)-Resistant Worms Reveals New Residues Required for DHP-Blockage of Mammalian Calcium Channels. PLoS Genetics 2008. PMID 18464914
  • Follicle-stimulating Hormone Does Not Impact Male Bone Mass in Vivo or Human Male Osteoclasts in Vitro. Other 2008. PMID 18465073
  • Microfabricated Channel Array Electrophoresis for Characterization and Screening of Enzymes Using RGS-G Protein Interactions as a Model System. Analytical Chemistry 2008. PMID 18465881
  • Identification of non-lipid LPA3 antagonists by virtual screening. Bioorganic and Medicinal Chemistry Journal 2008. PMID 18467108
  • Inhibitors of bacterial multidrug efflux pumps potentiate antimicrobial photoinactivation . Antimicrobial Agents and Chemotherapy 2008. PMID 18474586
  • Identification of halosalicylamide derivatives as a novel class of allosteric inhibitors of HCV NS5B polymerase. Bioorganic and Medicinal Chemistry Letters 2008. PMID 18479921
  • Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking . Proceedings of the National Academy of Sciences 2008. PMID 18480264
  • Novel Small Molecule Inhibitors for Prostate-Specific Antigen. Other 2008. PMID 18500692
  • Homology Modeling and Site-Directed Mutagenesis To Identify Selective Inhibitors of Endothelin-Converting Enzyme-2. Journal of Medicinal Chemistry 2008. PMID 18507370
  • Efficacy, Pharmacokinetics, Tisssue Distribution, and Metabolism of the Myc-Max Disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in Mice. Other 2008. PMID 18509642
  • Identification of auxins by a chemical genomics approach. Journal of Experimental Botany 2008. PMID 18515827
  • The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans -Golgi network. Biochemical Journal 2008. PMID 18522538
  • Larvicidal Activity of Sterol Carrier Protein-2 Inhibitor in Four Species of Mosquitoes. Journal of Medical Entomology 2008. PMID 18533437
  • Structure-based Discovery and Experimental Verification of Novel AI-2 Quorum Sensing Inhibitors Against Vibrio Harveyi. ChemMedChem 2008. PMID 18537200
  • A novel druglike spleen tyrosine kinase binder prevents anaphylactic shock when administered orally. The Journal of Allergy and Clinical Immunology 2008. PMID 18539317
  • Inside-Out: Signaling of Sphingosine-1-Phosphate: Therapeutic Targets. Pharmacological Reviews 2008. PMID 18552276
  • Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Human Intrauterine Growth Restriction. American Journal of Pathology 2008. PMID 18583310
  • Fragment-based Approach to Drug Lead Discovery: Overview and Advances in Various Techniques. Other 2008. PMID 18588353
  • A Specific Mechanism for Nonspecific Activation in Reporter-Gene Assays. ACS Chemical Biology 2008. PMID 18590332
  • Pmp-Like Proteins Pls1 and Pls2 Are Secreted into the Lumen of the Chlamydia trachomatis Inclusion. Infection and Immunity 2008. PMID 18591235
  • Development of Broad-Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CL(pro). Chemical Biology and Drug Design 2008. PMID 18611220
  • N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds. Bioorganic and Medicinal Chemistry Letters 2008. PMID 18621522
  • A TR3/Nur77 Peptide-Based High-Throughput Fluorescence Polarization Screen for Small Molecule Bcl-B Inhibitors. Journal of Biomolecular Screening 2008. PMID 18626112
  • Identification and Validation of Human DNA Ligase Inhibitors Using Computer-Aided Drug Design. Journal of Medicinal Chemistry 2008. PMID 18630893
  • Discovery of Novel Cathepsin S Inhibitors by Pharmacophore-Based Virtual High-Throughput Screening. Journal of Chemical Information and Modeling 2008. PMID 18637674
  • Lycopene Absorption in Human Intestinal Cells and in Mice Involves Scavenger Receptor Class B Type I but Not Niemann-Pick C1-Like 1. The Journal of Nutrition 2008. PMID 18641187
  • Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Molecular Pharmacology 2008. PMID 18664603
  • ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells. Virology 2008. PMID 18684481
  • Actin and intermediate filaments stabilize the Chlamydia trachomatis vacuole by forming dynamic structural scaffolds. Cell Host and Microbe 2008. PMID 18692775
  • The effect of particle design on cellular internalization pathways. Proceedings of the National Academy of Sciences 2008. PMID 18697944
  • The effect of particle design on cellular internalization pathways . Proceedings of the National Academy of Sciences 2008. PMID 18697944
  • Molecular Dynamics, Density Functional, ADMET Predictions, Virtual Screening, and Molecular Interaction Field Studies for Identification and Evaluation of Novel Potential CDK2 Inhibitors In Cancer Therapy. Journal of Physical Chemistry 2008. PMID 18698751
  • Inhibition of Serine Beta-Lactamases by Vanadate-Catechol Complexes. Biochemistry 2008. PMID 18702503
  • Small Molecules Can Selectively Inhibit Ephrin Binding to the EphA4 and EphA2 Receptors. Journal of Biological Chemistry 2008. PMID 18728010
  • Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. The Journal of Pharmacology and Experimental Therapeutics 2008. PMID 18772318
  • The Nociceptor Ion Channel TRPA1 is Potentiated and Inactivated by Permeating Calcium Ions. Journal of Biological Chemistry 2008. PMID 18775987
  • Discovery of Novel Nitrobenzothiazole Inhibitors for Mycobacterium tuberculosis ATP Phosphoribosyl Transferase (HisG) through Virtual Screening. Journal of Medicinal Chemistry 2008. PMID 18778048
  • Host Scavenger Receptor SR-BI Plays a Dual Role in the Establishment of Malaria Parasite Liver Infection. Cell Host and Microbe 2008. PMID 18779053
  • Chemical substructures that enrich for biological activity. Bioinformatics 2008. PMID 18784118
  • Identification of a Small Molecule with Synthetic Lethality for K-Ras and Protein Kinase C Iota. Cancer Research 2008. PMID 18794128
  • In Vitro Biologic Activities of the Antimicrobials Triclocarban, Its Analogs, and Triclosan in Bioassay Screens: Receptor-Based Bioassay Screens. Environmental Health Perspectives 2008. PMID 18795164
  • Small-molecule inhibition of HIV-1 Vif. Nature Biotechnology 2008. PMID 18806783
  • High-Throughput Screening of a 100,000-Compound Library for Inhibitors of Influenza A Virus (H3N2). Journal of Biomolecular Screening 2008. PMID 18812571
  • FAF-Drugs2: Free ADME/tox filtering tool to assist drug discovery and chemical biology projects. BMC Bioinformatics 2008. PMID 18816385
  • New auxin analogs with growth-promoting effects in intact plants reveal a chemical strategy to improve hormone delivery. Proceedings of the National Academy of Sciences 2008. PMID 18818305
  • Pharmacophore Modeling and Molecular Docking Led to the Discovery of Inhibitors of Human Immunodeficiency Virus-1 Replication Targeting the Human Cellular Aspartic Acid-Glutamic Acid-Alanine-Aspartic Acid Box Polypeptide 3. Journal of Medicinal Chemistry 2008. PMID 18834110
  • An Arf1 GTPase mutant with different responses to GEF inhibitors. Biochemical and Biophysical Research Communications 2008. PMID 18834864
  • A chemical compound that stimulates the human homologous recombination protein RAD51. Proceedings of the National Academy of Sciences 2008. PMID 18840682
  • Enhancing immunity to HIV through APOBEC. Nature Biotechnology 2008. PMID 18846074
  • Identification and characterization of small-molecule inhibitors of hepsin. Molecular Cancer Therapeutics 2008. PMID 18852137
  • A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proceedings of the National Academy of Sciences 2008. PMID 18852458
  • An Inhibitor of Gram-Negative Bacterial Virulence Protein Secretion. Cell Host and Microbe 2008. PMID 18854237
  • Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature 2008. PMID 18923525
  • AMMOS: Automated Molecular Mechanics Optimization tool for in silico Screening. BMC Bioinformatics 2008. PMID 18925937
  • Control of Parasitophorous Vacuole Expansion by LYST/Beige Restricts the Intracellular Growth of Leishmania amazonensis. PLoS Pathogens 2008. PMID 18927622
  • Aryl Acid Adenylating Enzymes Involved in Siderophore Biosynthesis: Fluorescence Polarization Assay, Ligand Specificity, and Discovery of Non-nucleoside Inhibitors via High-Throughput Screening. Biochemistry 2008. PMID 18928302
  • Screening Outside the Catalytic Site: Inhibition of Macromolecular Inter-actions Through Structure-Based Virtual Ligand Screening Experiments. The Open Biochemistry Journal 2008. PMID 18949072
  • HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Molecular Pain 2008. PMID 18954467
  • Fragment-Based Design of Small Molecule X-Linked Inhibitor of Apoptosis Protein Inhibitors. Journal of Medicinal Chemistry 2008. PMID 18956862
  • Identification of Pharmacological Chaperones for Gaucher Disease and Characterization of Their Effects on Beta-Glucocerebrosidase by hydrogen/deuterium Exchange Mass Spectrometry. ChemBioChem 2008. PMID 18972510
  • Thiobarbiturates as Sirtuin Inhibitors: Virtual Screening, Free-Energy Calculations, and Biological Testing. ChemMedChem 2008. PMID 18985648
  • A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death. Molecular Cancer Therapeutics 2008. PMID 19001437
  • Identification of Small Molecular Weight Inhibitors of Src Homology 2 Domain-Containing Tyrosine Phosphatase 2 (SHP-2) via in Silico Database Screening Combined with Experimental Assay. Journal of Medicinal Chemistry 2008. PMID 19007293
  • Binding Properties of the C-terminal Domain of VIAF. Chemical Biology and Drug Design 2008. PMID 19012568
  • Tetrazine-Based Cycloadditions: Application to Pretargeted Live Cell Imaging. Bioconjugate Chemistry 2008. PMID 19053305
  • Inhibitors of Tubulin Assembly Identified Through Screening a Compound Library. Chemical Biology and Drug Design 2008. PMID 19090918
  • Using Caenorhabditis elegans as a model organism for evaluating extracellular signal-regulated kinase docking domain inhibitors. Journal of Cell Communication and Signalling 2008. PMID 19105050
  • Small-Molecule Inhibitors of HIF-2a Translation Link Its 5\'UTR Iron-Responsive Element to Oxygen Sensing. Molecular Cell 2008. PMID 19111663
  • Cellular reporter screens for inhibitors of Burkholderia pseudomallei targets in Pseudomonas aeruginosa. Transactions of the Royal Society of Tropical Medicine and Hygiene 2008. PMID 19121678
  • Inhibiting Hdm2 and Ubiquitin-Activating Enzyme: Targeting the Ubiquitin Conjugating System in Cancer. Other 2008. PMID 19202599
  • Identification and Preliminary Characterization of a New Chemical Affecting Glucosyltransferase Activities Involved in Plant Cell Wall Biosynthesis. Molecular Plant 2008. PMID 19825597
  • Genomics: when the chemistry is good. Nature Methods 2008. PMID N/A
  • Lead-Likeness and Drug-Likeness. Wermuths The Practice of Medicinal Chemistry 2008. PMID N/A
  • A mild preparation of substituted indolizines and indole from simple aromatic precursors using (trimethylsilyl)diazomethane. Tetrahedron Letters 2008. PMID N/A
  • Virtual Fragment Scanning: Current Trends, Applications and Web‐Based Tools. Other 2008. PMID
  • Appendix. Other 2008. PMID
  • Abstracts of QSAR-related Publications: Data Base, Virtual Screening. Other 2008. PMID
  • High Throughput Screening (HTS ) Techniques: Applications in Chemical Biology. Other 2008. PMID
  • Abstracts of QSAR-related Publications: Molecular Modeling. Other 2008. PMID
  • Computer-aided predictions of potential antineoplastic agents. Other 2008. PMID
  • Non-Peptidic Mimetics as Cancer-Sensitizing Agents. Book Chapter 2008. PMID
  • Identification of Small-Molecule Inhibitors of RGS4 Using a High-Throughput Flow Cytometry Protein Interaction Assay. Molecular Pharmacology 2007. PMID 17012620
  • Identification of Anti-prion Compounds as Efficient Inhibitors of Polyglutamine Protein Aggregation in a Zebrafish Model. Journal of Biological Chemistry 2007. PMID 17170113
  • Chemical genetic approaches to probing cell death. Current Opinion in Chemical Biology 2007. PMID 17174591
  • A High-Throughput Cell-Based Assay to Identify Specific Inhibitors of Transcription Factor AP-1. Journal of Biomolecular Screening 2007. PMID 17175522
  • Pseudolipasin A Is a Specific Inhibitor for Phospholipase A2 Activity of Pseudomonas aeruginosa Cytotoxin ExoU.. Infection and Immunity 2007. PMID 17178785
  • Outsourcing lead optimization: constant change is here to stay. Drug Discovery Today 2007. PMID 17198974
  • CYCLONET - an integrated database on cell cycle regulation and carcinogenesis. Nucleic Acids Research 2007. PMID 17202170
  • Determination of Phenolic Metabolites of Polycyclic Aromatic Hydrocarbons in Human Urine as Their Pentafluorobenzyl Ether Derivatives Using Liquid Chromatography-Tandem Mass Spectrometry. Analytical Chemistry 2007. PMID 17222024
  • Small-Molecule Screening: It Takes a Village . ACS Chemical Biology 2007. PMID 17243777
  • Small-Molecule Inhibition of the Interaction between the Translation Initiation Factors eIF4E and eIF4G. Cell 2007. PMID 17254965
  • Synthesis and Cellular Profiling of Diverse Organosilicon Small Molecules. Journal of the American Chemical Society 2007. PMID 17263369
  • Anticancer and chemosensitizing effects of 2,3-DCPE in ovarian carcinoma cell lines: Link with ERK activation and modulation of p21WAF1/CIP1, Bcl-2 and Bcl-xL expression. Gynecologic Oncology 2007. PMID 17276501
  • Multiplexed Detection of Protein-Peptide Interaction and Inhibition Using Capillary Electrophoresis. Analytical Chemistry 2007. PMID 17297974
  • Subunit-specific Mechanisms and Proton Sensitivity of NMDA Receptor Channel Block. Other 2007. PMID 17303642
  • Identification of Nonpeptide CCR5 Receptor Agonists by Structure-based Virtual Screening. Journal of Medicinal Chemistry 2007. PMID 17311371
  • Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors. Bioorganic and Medicinal Chemistry Letters 2007. PMID 17350260
  • Structure-based discovery of new small molecule inhibitors of low molecular weight protein tyrosine phosphatase. European Journal of Medicinal Chemistry 2007. PMID 17367895
  • A comparison of the chemical properties of drugs and FEMA/FDA notified GRAS chemical compounds used in the food industry. Food and Chemical Toxicology 2007. PMID 17368904
  • Discovery of a Novel Small-Molecule Targeting Selective Clearance of Mutant Huntingtin Fragments. Journal of Biomolecular Screening 2007. PMID 17379859
  • Morlin, an inhibitor of cortical microtubule dynamics and cellulose synthase movement . Proceedings of the National Academy of Sciences 2007. PMID 17389408
  • Composite synthetic lethal identification of membrane traffic inhibitors . Proceedings of the National Academy of Sciences 2007. PMID 17404221
  • Oligomeric Benzylsulfonium Salts: Facile Benzylation via High-Load ROMP Reagents. Journal of Organic Chemistry 2007. PMID 17407352
  • eIF2-alpha Phosphorylation Bidirectionally Regulates the Switch from Short- to Long-Term Synaptic Plasticity and Memory . Cell 2007. PMID 17418795
  • Target-Based Approach to Inhibitors of Histone Arginine Methyltransferases. Journal of Medicinal Chemistry 2007. PMID 17432842
  • Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants. Nature Chemical Biology 2007. PMID 17435769
  • HTS, Chemical Hybridization, and Drug Design Identify a Chemically Unique Antituberculosis Agent-Coupling Serendipity and Rational Approaches to Drug Discovery. ChemMedChem 2007. PMID 17455191
  • WinDock: Structure-Based Drug Discovery on Windows-based PCs. Journal of Computational Chemistry 2007. PMID 17476686
  • MED-SuMoLig: A New Ligand-Based Screening Tool for Efficient Scaffold Hopping. Journal of Chemical Information and Modeling 2007. PMID 17477521
  • Frog: a FRee Online druG 3D conformation generator. Nucleic Acids Research 2007. PMID 17485475
  • Small molecules enhance autophagy and reduce toxicity in Huntingdon\'s disease models. Nature Chemical Biology 2007. PMID 17486044
  • Selection Strategy and the Design of Hybrid Oligonucleotide Primers for RACE-PCR: Cloning a Family of Toxin-Like Sequences From Agelena Orientalis. Other 2007. PMID 17498297
  • Inhibition of Type III Secretion in Salmonella enterica Serovar Typhimurium by Small-Molecule Inhibitors . Antimicrobial Agents and Chemotherapy 2007. PMID 17502403
  • Critical Role for Fas-associated Death Domain-Like interleukin-1-converting Enzyme-Like Inhibitory Protein in Anoikis Resistance and Distant Tumor Formation. Other 2007. PMID 17505076
  • Discovery of novel dialkyl substituted thiophene inhibitors of HCV by in silico screening of the NS5B RdRp. Bioorganic and Medicinal Chemistry Letters 2007. PMID 17512198
  • An Improved Beta-Lactamase Reporter Assay: Multiplexing With a Cytotoxicity Readout for Enhanced Accuracy of Hit Identification. Journal of Biomolecular Screening 2007. PMID 17517902
  • Human GCIP Interacts With CT847, a Novel Chlamydia Trachomatis Type III Secretion Substrate, and Is Degraded in a Tissue-Culture Infection Model. Cellular Microbiology 2007. PMID 17532760
  • Small-molecule activators of RNase L with broad-spectrum antiviral activity. Proceedings of the National Academy of Sciences 2007. PMID 17535916
  • Activation of Inhibitors by Sortase Triggers Irreversible Modification of the Active Site*. Journal of Biological Chemistry 2007. PMID 17545669
  • Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes. Proceedings of the National Academy of Sciences 2007. PMID 17563369
  • Discovery of a Highly Active Ligand of Human Pregnane X Receptor: A Case Study from Pharmacophore Modeling and Virtual Screening to In Vivo Biological Activity. Molecular Pharmacology 2007. PMID 17573484
  • Sirtuin 2 Inhibitors Rescue a-Synuclein-Mediated Toxicity in Models of Parkinson's Disease. Science 2007. PMID 17588900
  • Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs . Proceedings of the National Academy of Sciences 2007. PMID 17606915
  • Hot spots in prion protein for pathogenic conversion . Proceedings of the National Academy of Sciences 2007. PMID 17616582
  • Novel antagonists of the thioesterase domain of human fatty acid synthase. Molecular Cancer Therapeutics 2007. PMID 17620441
  • Structure-activity Studies on Suramin Analogues as Inhibitors of NAD+-dependent Histone Deacetylases (Sirtuins). ChemMedChem 2007. PMID 17628866
  • Inhibition of the Bacterial Heme Oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: Novel Antimicrobial Targets. Journal of Medicinal Chemistry 2007. PMID 17629261
  • Scaffold composition and biological relevance of screening libraries. Nature Chemical Biology 2007. PMID 17637770
  • Novel Inhibitors of Alkaline Phosphatase Suppress Vascular Smooth Muscle Cell Calcification. Other 2007. PMID 17638573
  • Proteomic Applications of Automated GPCR Classification. Other 2007. PMID 17639603
  • Design of protein membrane interaction inhibitors by virtual ligand screening, proof of concept with the C2 domain of factor V . Proceedings of the National Academy of Sciences 2007. PMID 17646652
  • The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face. Biochimica et Biophysica Acta 2007. PMID 17660054
  • Necrostatin: a potentially novel cardioprotective agent?. Cardiovascular Drugs and Therapy 2007. PMID 17665295
  • Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease . Proceedings of the National Academy of Sciences 2007. PMID 17670938
  • Targeting Plague Virulence Factors: A Combined Machine Learning Method and Multiple Conformational Virtual Screening for the Discovery of Yersinia Protein Kinase A Inhibitors. Journal of Medicinal Chemistry 2007. PMID 17676727
  • Transcriptional Inhibition of Human Papilloma Virus in Cervical Carcinoma Cells Reactivates Functions of the Tumor Suppressor p53. Other 2007. PMID 17685229
  • TRPA1 Mediates Formalin-induced Pain. Proceedings of the National Academy of Sciences 2007. PMID 17686976
  • Linking SIRT2 to Parkinsons Disease. ACS Chemical Biology 2007. PMID 17708669
  • Small molecules not direct activators of caspases. Nature Chemical Biology 2007. PMID 17710090
  • Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides. Bioorganic and Medicinal Chemistry Journal 2007. PMID 17723305
  • Changes in Drosophila Melanogaster Midgut Proteins in Response to Dietary Bowman-Birk Inhibitor. Insect Molecular Biology 2007. PMID 17725801
  • Design of New Plasmepsin Inhibitors: A Virtual High Throughput Screening Approach on the EGEE Grid. Journal of Chemical Information and Modeling 2007. PMID 17727268
  • Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells. Journal of Neurochemistry 2007. PMID 17760869
  • Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening. Bioorganic and Medicinal Chemistry Journal 2007. PMID 17761421
  • Differentiating Alzheimer disease-associated aggregates with small molecules. Neurobiology of Disease 2007. PMID 17761424
  • Chemical Genetic Screening Identifies a Novel Inhibitor of Parallel Alignment of Cortical Microtubules and Cellulose Microfibrils. Other 2007. PMID 17875587
  • Improved low molecular weight Myc-Max inhibitors. Molecular Cancer Therapeutics 2007. PMID 17876039
  • Sphingolipids and the Sphingosine Kinase Inhibitor, SKI II, Induce BCL-2-independent Apoptosis in Human Prostatic Adenocarcinoma Cells. Other 2007. PMID 17879964
  • Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2\'O)-methyltransferase. Bioorganic and Medicinal Chemistry Journal 2007. PMID 17888664
  • BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development. Toxicology Letters 2007. PMID 17890024
  • Chemical genetic interrogation of natural variation uncovers a molecule that is glycoactivated. Nature Chemical Biology 2007. PMID 17891152
  • Non-carbohydrate inhibitors of Lectin DC-Sign. Journal of the American Chemical Society 2007. PMID 17902657
  • Small Molecule Inhibitors of the MDM2-p53 Interaction Discovered by Ensemble-Based Receptor Models. Journal of the American Chemical Society 2007. PMID 17902662
  • Inhibitors of Ubiquitin-Activating Enzyme (E1), a New Class of Potential Cancer Therapeutics. Cancer Research 2007. PMID 17909057
  • A surface on the androgen receptor that allosterically regulates coactivator binding . Proceedings of the National Academy of Sciences 2007. PMID 17911242
  • Small Molecules Block the Polymerization of Z alpha1-Antitrypsin and Increase the Clearance of Intracellular Aggregates. Journal of Medicinal Chemistry 2007. PMID 17918823
  • De Novo Discovery of Serotonin N-Acetyltransferase Inhibitor. Journal of Medicinal Chemistry 2007. PMID 17924613
  • Cell-based high-content screening of small-molecule libraries. Current Opinion in Chemical Biology 2007. PMID 17931958
  • The Small Molecule 2-furylacrylic Acid Inhibits Auxin-Mediated Responses in Arabidopsis Thaliana. Other 2007. PMID 17942448
  • Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis. Journal of Medicinal Chemistry 2007. PMID 17948983
  • Nuclear Magnetic Resonance Fragment-Based Identification of Novel FKBP12 Inhibitors. Journal of Medicinal Chemistry 2007. PMID 18038971
  • Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein . Proceedings of the National Academy of Sciences 2007. PMID 18042718
  • Design and Synthesis of Human Immunodeficiency Virus Entry Inhibitors: Sulfonamide as an Isostere for the alpha-Ketoamide Group. Journal of Medicinal Chemistry 2007. PMID 18052117
  • LRET-based HTS of a small-compound library for inhibitors of bacterial RNA polymerase.. Assay and Drug Development Technologies 2007. PMID 18052851
  • A novel high-throughput screening system identifies a small molecule repressive for matrix metalloproteinase-9 expression. Molecular Pharmacology 2007. PMID 18065684
  • Identification of the Molecular Target of Small Molecule Inhibitors of HDL Receptor SR-BI Activity. Biochemistry 2007. PMID 18067275
  • Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop adaptability in selective inhibition of bacterial enzymes. BMC Structural Biology 2007. PMID 18093325
  • Arabidopsis P-Glycoprotein19 Participates in the Inhibition of Gravitropism by Gravacin. Chemistry and Biology 2007. PMID 18096505
  • Straightforward transformation of isoxazoles into pyrazoles: renewed and improved. Tetrahedron 2007. PMID N/A
  • Novel Antiviral Agents Targeting HIV Entry and Transmission. Virologica Sinica 2007. PMID N/A
  • 5-Hexylidene-4-propylamino-1,5-dihydroimidazol-2-one formed from Cu-catalyzed oxidation with implication for the structure of a His-Lys cross-link. Chinese Chemical Letters 2007. PMID N/A
  • High-throughput screening goes to school. Nature Methods 2007. PMID N/A
  • High Throughput Screening of a 100,000 Compound Library for Inhibitors of Influenza A Virus (H3N2). Antiviral Research 2007. PMID N/A
  • Effect of UV Curing on Electrical Properties of a UV‐Curable co‐Polyacrylate/Silica Nanocomposite as a Transparent Encapsulation Resin for Device Packaging. Other 2007. PMID
  • Structuring the process of search and analysis of scientific and technical information. Other 2007. PMID
  • Grid-enabled Virtual Screening Against Malaria. Other 2007. PMID
  • Cross-coupling of polychlorobenzenes with phenylboronic acid in the presence of [Pd]-imidazolium salts as catalytic systems. Other 2007. PMID
  • Transparent photo‐curable co‐polyacrylate/silica nanocomposites prepared by sol‐gel process. Journal of Applied Polymer Science 2007. PMID
  • Targeting Bcl‐XL for prevention and therapy of skin cancer. Molecular Carcinogenesis 2007. PMID
  • High Throughput Screening in Agrochemical Research. Book Chapter 2007. PMID
  • Abstracts of QSAR-related Publications: 3D QSAR. Other 2007. PMID
  • Lead Identification by Virtual Screening. Book Chapter 2007. PMID
  • One-pot synthesis of substituted styrenes from vicinal dibromoalkanes and arylboronic acids. Other 2007. PMID
  • Practice and Products. In: Chemoinformatics. Book Chapter 2007. PMID
  • Screening for Inhibitors of Microtubule-Associated Motor Proteins. Other 2007. PMID
  • Neurite Outgrowth in Retinal Ganglion Cell Culture. Other 2007. PMID