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2013-2014 Research Articles Citing ChemBridge

Below is a partial list of articles citing the use of ChemBridge libraries and compounds. The list is updated as additional articles are identified. The PMID value can be used to link to the record at the PubMed website.

• Transient receptor potential (TRP) channels: a clinical perspective. British Journal of Pharmacology 2014. PMID 24102319
• Cell-based bioluminescence screening assays.. Book Chapter 2014. PMID 24166378
• Identification of Novel Rab27a/Melanophilin Blockers by Pharmacophore-Based Virtual Screening. Applied Biochemistry and Biotechnology 2014. PMID 24293275
• Fully automated compound screening in Arabidopsis thaliana seedlings.. Book Chapter 2014. PMID 24306857
• Application of yeast-two hybrid assay to chemical genomic screens: a high-throughput system to identify novel molecules modulating plant hormone receptor complexes.. Book Chapter 2014. PMID 24306860
• Investigating the phytohormone ethylene response pathway by chemical genetics.. Book Chapter 2014. PMID 24306863
• Plant chemical genomics: gravity sensing and response.. Book Chapter 2014. PMID 24306868
• Screening chemical libraries for compounds that affect protein sorting to the yeast vacuole.. Book Chapter 2014. PMID 24306869
• The use of multidrug approach to uncover new players of the endomembrane system trafficking machinery.. Book Chapter 2014. PMID 24306870
• 1H NMR-based metabolomics methods for chemical genomics experiments.. Book Chapter 2014. PMID 24306877
• Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif. FEBS Letters 2014. PMID 24314137
• QSAR Modeling: Where Have You Been? Where Are You Going To?. Journal of Medicinal Chemistry 2014. PMID 24351051
• Virtual Screening of PRK1 Inhibitors: Ensemble Docking, Rescoring Using Binding Free Energy Calculation and QSAR Model Development. Journal of Chemical Information and Modeling 2014. PMID 24377786
• Selective ALDH3A1 Inhibition by Benzimidazole Analogues Increase Mafosfamide Sensitivity in Cancer Cells. Journal of Medicinal Chemistry 2014. PMID 24387105
• Identification of Clinically Viable Quinolinol Inhibitors of Botulinum Neurotoxin A Light Chain. Journal of Medicinal Chemistry 2014. PMID 24387280
• Covalent inhibition of the lymphoid tyrosine phosphatase. ChemMedChem 2014. PMID 24403103
• Rearrangements leading to fragmentations of hydrocinnamate and analogous nitrogen-containing anions upon collision-induced dissociation.. Journal of the American Society for Mass Spectrometry 2014. PMID 24408178
• Activation of the Proapoptotic Bcl-2 Protein Bax by a Small Molecule Induces Tumor Cell Apoptosis. Molecular and Cellular Biology 2014. PMID 24421393
• 1H-1,2,3-Triazole-tethered isatin-7-chloroquinoline and 3-hydroxy-indole-7-chloroquinoline conjugates: Synthesis and antimalarial evaluation. Bioorganic and Medicinal Chemistry Letters 2014. PMID 24424135
• An Unconventional Secretory Pathway Mediates the Cilia Targeting of Peripherin/rds. Journal of Neuroscience 2014. PMID 24431457
• B-type natriuretic peptide is neither itch-specific nor functions upstream of the GRP-GRPR signaling pathway. Molecular Pain 2014. PMID 24438367
• High-throughput, high-content screening for novel pigmentation regulators using a keratinocyte/melanocyte co-culture system. Experimental Dermatology 2014. PMID 24438532
• TR-DB: An open-access database of compounds affecting the ethylene-induced triple response in Arabidopsis. Plant Physiology and Biochemistry 2014. PMID 24441765
• Development of Selective Inhibitors for Aldehyde Dehydrogenases Based on Substituted Indole-2,3-diones. Journal of Medicinal Chemistry 2014. PMID 24444054
• Benzofuran derivatives as a novel class of inhibitors of mTOR signaling. European Journal of Medicinal Chemistry 2014. PMID 24445311
• Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium tuberculosis InhA. Journal of Medicinal Chemistry 2014. PMID 24450589
• Mutations in the Pseudomonas aeruginosa Needle Protein Gene pscF Confer Resistance to Phenoxyacetamide Inhibitors of the Type III Secretion System . Antimicrobial Agents and Chemotherapy 2014. PMID 24468789
• Prospective virtual screening in a sparse data scenario: design of small-molecule TLR2 antagonists. ChemMedChem 2014. PMID 24470159
• Euodenine A: A Small-Molecule Agonist of Human TLR4. Journal of Medicinal Chemistry 2014. PMID 24471857
• Allosteric Noncompetitive Small Molecule Selective Inhibitors of CD45 Tyrosine Phosphatase Suppress T-Cell Receptor Signals and Inflammation In Vivo. Molecular Pharmacology 2014. PMID 24473749
• Zinc depletion regulates the processing and secretion of IL-1 beta. Cell Death and Disease 2014. PMID 24481454
• Proteasomal Degradation of g-Aminobutyric AcidB Receptors Is Mediated by the Interaction of the GABA B2 C Terminus with the Proteasomal ATPase Rtp6 and Regulated by Neuronal Activity. Journal of Biological Chemistry 2014. PMID 24482233
• Activation and Inhibition of Thermosensitive TRP Channels by Voacangine, an Alkaloid Present in Voacanga africana, an African Tree. Journal of Natural Products 2014. PMID 24484240
• High-throughput screening identifies inhibitors of DUX4-induced myoblast toxicity. Skeletal Muscle 2014. PMID 24484587
• Computation-Guided Discovery of Influenza Endonuclease Inhibitors. ACS Medicinal Chemistry Letters 2014. PMID 24490002
• Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proceedings of the National Academy of Sciences 2014. PMID 24492375
• Identification of a Broad-Spectrum Antiviral Small Molecule against Severe Acute Respiratory Syndrome Coronavirus and Ebola, Hendra, and Nipah Viruses by Using a Novel High-Throughput Screening Assay . Journal of Virology 2014. PMID 24501399
• Piperazine derivatives inhibit PrP/PrPres propagation in vitro and in vivo. Biochemical and Biophysical Research Communications 2014. PMID 24502948
• Tiotropium modulates transient receptor potential V1 (TRPV1) in airway sensory nerves: A beneficial off-target effect?. The Journal of Allergy and Clinical Immunology 2014. PMID 24506933
• Identification of novel small molecule inhibitors of activated protein C. Thrombosis Research 2014. PMID 24513148
• Small-Molecule Library Subset Screening as an Aid for Accelerating Lead Identification. Journal of Biomolecular Screening 2014. PMID 24518067
• A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods. Nature Communications 2014. PMID 24518821
• Identification of Novel Serotonin Transporter Compounds by Virtual Screening. Journal of Chemical Information and Modeling 2014. PMID 24521202
• Mitochondrial FAD-linked Glycerol-3-phosphate Dehydrogenase: A Target for Cancer Therapeutics. Pharmaceuticals 2014. PMID 24521925
• A Duplexed High-Throughput Screen to Identify Allosteric Modulators of the Glucagon-Like Peptide 1 and Glucagon Receptors. Journal of Biomolecular Screening 2014. PMID 24525870
• Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells. Bioorganic and Medicinal Chemistry Journal 2014. PMID 24530226
• Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002. Acta Crystallographica - All Sections 2014. PMID 24531473
• Antibiotic targeting of the bacterial secretory pathway. Biochimica et Biophysica Acta 2014. PMID 24534745
• Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. Nature Communications 2014. PMID 24548894
• Virtual Screening of Some Active Human Macrophage Migration Inhibitory Factor Antagonists. Journal of Biomolecular Screening 2014. PMID 24554444
• The Dynamic Character of the BCL2 Promoter i‑Motif Provides a Mechanism for Modulation of Gene Expression by Compounds That Bind Selectively to the Alternative DNA Hairpin Structure. Journal of the American Chemical Society 2014. PMID 24559410
• Angiogenin promotes tumoral growth and angiogenesis by regulating matrix metallopeptidase-2 expression via the ERK1/2 pathway.. Oncogene 2014. PMID 24561529
• Identification of small molecules that support human leukemia stem cell activity ex vivo. Nature Methods 2014. PMID 24562423
• N-Acylated Derivatives of Sulfamethoxazole and Sulfafurazole Inhibit Intracellular Growth of Chlamydia trachomatis. Antimicrobial Agents and Chemotherapy 2014. PMID 24566180
• Discovery of PI-1840, a Novel Noncovalent and Rapidly Reversible Proteasome Inhibitor with Anti-tumor Activity. Journal of Biological Chemistry 2014. PMID 24570003
• Inhibitors of TonB Function Identified by a High-Throughput Screen for Inhibitors of Iron Acquisition in Uropathogenic Escherichia coli CFT073. mBio 2014. PMID 24570372
• Akt and mTOR mediate programmed necrosis in neurons.. Cell Death and Disease 2014. PMID 24577082
• Differences in conformational dynamics between Plasmodium falciparum and human Hsp90 orthologues enable the structure-based discovery of pathogen-selective inhibitors.. Journal of Medicinal Chemistry 2014. PMID 24580531
• Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors. Journal of Biomolecular Screening 2014. PMID 24598103
• Targeting exosites of activated protein C as therapeutic possibility?. Thrombosis Research 2014. PMID 24612601
• Identification of Novel Potential Antibiotics against Staphylococcus Using Structure-Based Drug Screening Targeting Dihydrofolate Reductase. Journal of Chemical Information and Modeling 2014. PMID 24655350
• Targeted inhibition of cell-surface serine protease Hepsin blocks prostate cancer bone metastasis.. Oncotarget 2014. PMID 24657880
• Plant GSK3 proteins regulate xylem cell differentiation downstream of TDIF–TDR signalling. Nature Communications 2014. PMID 24662460
• The transcriptional modulator BCL6 as a molecular target for breast cancer therapy. Oncogene 2014. PMID 24662818
• Identification and Characterization of Small Molecules That Inhibit Nonsense-Mediated RNA Decay and Suppress Nonsense p53 Mutations. Cancer Research 2014. PMID 24662918
• The TRPA1 channel in inflammatory and neuropathic pain and migraine.. Book Chapter 2014. PMID 24668446
• Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity. ChemBioChem 2014. PMID 24677340
• Biofragments: an approach towards predicting protein function using biologically related fragments and its application to Mycobacterium tuberculosis CYP126. ChemBioChem 2014. PMID 24677424
• Discovery of 5-(2-(Phenylamino)pyrimidin-4-yl)thiazol- 2(3H)-one Derivatives as Potent Mnk2 Inhibitors: Synthesis, SAR Analysis and Biological Evaluation. ChemMedChem 2014. PMID 24677692
• Identification and Characterization of Small Molecule Modulators of the Epstein-Barr Virus-Induced Gene 2 (EBI2) Receptor. Journal of Medicinal Chemistry 2014. PMID 24678947
• Sulphur-containing compounds of durian activate the thermogenesis-inducing receptors TRPA1 and TRPV1. Food Chemistry 2014. PMID 24679773
• Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate. Journal of Biomolecular Screening 2014. PMID 24687155
• Discovery of Novel Cell Wall-Active Compounds Using P ywaC, a Sensitive Reporter of Cell Wall Stress, in the Model Gram-Positive Bacterium Bacillus subtilis. Antimicrobial Agents and Chemotherapy 2014. PMID 24687489
• In Vitro and In Vivo Activities of HPi1, a Selective Antimicrobial against Helicobacter pylori. Antimicrobial Agents and Chemotherapy 2014. PMID 24687512
• A novel Lipoprotein lipase (LPL) agonist rescues the enzyme from inhibition by angiopoietin-like 4 (ANGPTL4). Bioorganic and Medicinal Chemistry Letters 2014. PMID 24703657
• Discovery of Novel Inhibitors Targeting the Macrophage Migration Inhibitory Factor via Structure-Based Virtual Screening and Bioassays. Journal of Medicinal Chemistry 2014. PMID 24712915
• In Silico Identification and in Vitro Validation of Potential Cholestatic Compounds through 3D Ligand-Based Pharmacophore Modeling of BSEP Inhibitors. Chemical Research in Toxicology 2014. PMID 24713091
• Toward understanding ubiquitin-modifying enzymes: from pharmacological targeting to proteomics. Trends in Pharmacological Sciences 2014. PMID 24717260
• A BSL-4 High-Throughput Screen Identifies Sulfonamide Inhibitors of Nipah Virus. Assay and Drug Development Technologies 2014. PMID 24735442
• Yeast Synthetic Biology Platform Generates Novel Chemical Structures as Scaffolds for Drug Discovery. ACS Synthetic Biology 2014. PMID 24742115
• Identification of inhibitors of inositol 5-phosphatases through multiple screening strategies.. ACS Chemical Biology 2014. PMID 24742366
• Structure-based discovery of a small non-peptidic Neuropilins antagonist exerting in vitro and in vivo anti-tumor activity on breast cancer model. Cancer Letters 2014. PMID 24752068
• Copper Complexation Screen Reveals Compounds with Potent Antibiotic Properties against Methicillin-Resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 2014. PMID 24752262
• Discovery of novel bacterial elongation condensing enzyme inhibitors by virtual screening. Bioorganic and Medicinal Chemistry Letters 2014. PMID 24755430
• TRPA1.. Book Chapter 2014. PMID 24756722
• A multi-fingerprint browser for the ZINC database. Nucleic Acids Research 2014. PMID 24782520
• An exhaustive yet simple virtual screening campaign against Sortase A from multiple drug resistant Staphylococcus aureus.. Molecular Biology Reports 2014. PMID 24797540
• Screening for Inhibition of Vibrio cholerae VipA-VipB Interaction Identifies Small-Molecule Compounds Active against Type VI Secretion. Antimicrobial Agents and Chemotherapy 2014. PMID 24798289
• Identification and Characterization of a Novel Small-Molecule Inhibitor of beta-Catenin Signaling . American Journal of Pathology 2014. PMID 24819961
• Identification of biologically active, HIV TAR RNA-binding small molecules using small molecule microarrays.. Journal of the American Chemical Society 2014. PMID 24820959
• A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer’s disease mice. Journal of Experimental Medicine 2014. PMID 24821909
• Undecaprenyl diphosphate synthase inhibitors: antibacterial drug leads.. Journal of Medicinal Chemistry 2014. PMID 24827744
• Selective Small Molecule Compounds Increase BMP-2 Responsiveness by Inhibiting Smurf1-mediated Smad1/5 Degradation. Scientific Reports 2014. PMID 24828823
• Opioid Receptor Function Is Regulated by Post-endocytic Peptide Processing . Journal of Biological Chemistry 2014. PMID 24847082
• Targeting the homologous recombination pathway by small molecule modulators. Bioorganic and Medicinal Chemistry Letters 2014. PMID 24856061
• β‑Lactoglobulin as a Vector for β‑Carotene Food Fortification. Journal of Agricultural and Food Chemistry 2014. PMID 24857546
• Effective Virtual Screening Strategy toward Covalent Ligands: Identification of Novel NEDD8-Activating Enzyme Inhibitors. Journal of Chemical Information and Modeling 2014. PMID 24857708
• AlphaLISA-based high-throughput screening assay to measure levels of soluble amyloid precursor protein a. Analytical Biochemistry 2014. PMID 24857774
• Hepatitis B virus replication is blocked by a 2-hydroxyisoquinoline- 1,3(2H,4H)-dione (HID) inhibitor of the viral ribonuclease H activity. Antiviral Research 2014. PMID 24858512
• Identification of a novel multiple kinase inhibitor with potent antiviral activity against influenza virus by reducing viral polymerase activity. Biochemical and Biophysical Research Communications 2014. PMID 24858693
• Endosidin 7 Specifically Arrests Late Cytokinesis and Inhibits Callose Biosynthesis, Revealing Distinct Trafficking Events during Cell Plate Maturation. Plant Physiology 2014. PMID 24858949
• A Fragment-Based Method to Discover Irreversible Covalent Inhibitors of Cysteine Proteases. Journal of Medicinal Chemistry 2014. PMID 24870364
• Structure-based Design, Synthesis, and Biological Evaluation of Isatin Derivatives as Potential Glycosyltransferase Inhibitors. Chemical Biology and Drug Design 2014. PMID 24890564
• Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor.. ACS Medicinal Chemistry Letters 2014. PMID 24900838
• Mitochondrial Perturbation Negatively Affects Auxin Signaling. Molecular Plant 2014. PMID 24903751
• Targeting Mycobacterium tuberculosis nucleoid-associated protein HU with structure-based inhibitors. Nature Communications 2014. PMID 24916461
• Allosteric inhibition of a stem cell RNA-binding protein by an intermediary metabolite. eLife 2014. PMID 24935936
• Discovery and structure–activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors. Bioorganic and Medicinal Chemistry Letters 2014. PMID 24939758
• Discovery of novel inhibitors of vascular endothelial growth factor-A–Neuropilin-1 interaction by structure-based virtual screening. Bioorganic and Medicinal Chemistry Journal 2014. PMID 24961874
• TRPs: modulation by drug-like compounds.. Book Chapter 2014. PMID 24961981
• Applications of structure-based design to antibacterial drug discovery. Bioorganic Chemistry 2014. PMID 24962384
• High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4). Biochemical Pharmacology 2014. PMID 24973542
• Discovery of a benzofuran derivative (MBPTA) as a novel ROCK inhibitor that protects against MPP+-induced oxidative stress and cell death in SH-SY5Y cells. Free Radical Biology and Medicine 2014. PMID 24973649
• Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.. Nature Chemical Biology 2014. PMID 24974230
• A utophagy induction enhances TDP 43 turnover and survival in neuronal ALS models. Nature Chemical Biology 2014. PMID 24974230
• Novel Bayesian classification models for predicting compounds blocking hERG potassium channels.. Acta Pharmacologica Sinica 2014. PMID 24976154
• Identification of a small molecule that stabilizes lipoprotein lipase in vitro and lowers triglycerides in vivo. Biochemical and Biophysical Research Communications 2014. PMID 24984153
• Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson’s disease cell and mouse models. Human Molecular Genetics 2014. PMID 24993787
• HTS/HCS to screen molecules able to maintain embryonic stem cell self-renewal or to induce differentiation: overview of protocols.. Stem Cell Reviews 2014. PMID 25007774
• Allosteric pocket of the dengue virus (serotype 2) NS2B/NS3 protease: In silico ligand screening and molecular dynamics studies of inhibition. Journal of Molecular Graphics and Modelling 2014. PMID 25023665
• 6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27. Cell Death and Disease 2014. PMID 25032860
• Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. European Journal of Medicinal Chemistry 2014. PMID 25036789
• Multi-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism. European Journal of Medicinal Chemistry 2014. PMID 25036790
• Contact sensitizer 2,4-dinitrochlorobenzene is a highly potent human TRPA1 agonist. Allergy 2014. PMID 25041656
• In silico studies and fluorescence binding assays of potential anti-prion compounds reveal an important binding site for prion inhibition from PrPC to PrPSc. European Journal of Medicinal Chemistry 2014. PMID 25042003
• Structure-Based Discovery of Selective Serotonin 5-HT1B Receptor Ligands. Structure 2014. PMID 25043551
• Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis. Journal of Neuroinflammation 2014. PMID 25043939
• Design of a general-purpose European compound screening library for EU-OPENSCREEN. ChemMedChem 2014. PMID 25044981
• Small Molecule that Reverses Dexamethasone Resistance in T-cell Acute Lymphoblastic Leukemia (T-ALL).. ACS Medicinal Chemistry Letters 2014. PMID 25050160
• Identification of Indole Alkaloid Structural Units Important for Stimulus-Selective TRPM8 Inhibition: SAR Study of Naturally Occurring Iboga Derivatives.. Journal of Natural Products 2014. PMID 25052206
• Systematic evaluation and optimization of modification reactions of oligonucleotides with amines and carboxylic acids for the synthesis of DNA-encoded chemical libraries.. Bioconjugate Chemistry 2014. PMID 25061844
• Identification of a small molecule that increases hemoglobin oxygen affinity and reduces SS erythrocyte sickling.. ACS Chemical Biology 2014. PMID 25061917
• An allosteric modulator of HIV-1 protease shows equipotent inhibition of wild-type and drug-resistant proteases.. Journal of Medicinal Chemistry 2014. PMID 25062388
• Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors. FEBS Letters 2014. PMID 25063338
• Hierarchical virtual screening approaches in small molecule drug discovery. Methods 2014. PMID 25072167
• Development of quinone analogues as dynamin GTPase inhibitors. European Journal of Medicinal Chemistry 2014. PMID 25084145
• P300-dependent STAT3 acetylation is necessary for angiotensin II-induced pro-fibrotic responses in renal tubular epithelial cells.. Acta Pharmacologica Sinica 2014. PMID 25088002
• Structural analysis of H1N1 and H7N9 influenza A virus PA in the absence of PB1. Scientific Reports 2014. PMID 25089892
• Discovery of a novel class of diacylglycerol acyltransferase 2 inhibitors with a 1H-pyrrolo[2,3-b]pyridine core. Biological and Pharmaceutical Bulletin 2014. PMID 25099343
• Identification of a Putative Tdp1 Inhibitor (CD00509) by in Vitro and Cell-Based Assays. Journal of Biomolecular Screening 2014. PMID 25117203
• Discovery of New Uncompetitive Inhibitors of Glucose-6-Phosphate Dehydrogenase. Journal of Biomolecular Screening 2014. PMID 25121555
• Ebselen inhibits hepatitis C virus NS3 helicase binding to nucleic acid and prevents viral replication.. ACS Chemical Biology 2014. PMID 25126694
• Discovery of a novel HIV-1 integrase inhibitor from natural compounds through structure based virtual screening and cell imaging. FEBS Letters 2014. PMID 25128456
• Screening and identification of novel compounds with potential anti-proliferative effects on gallium-resistant lung cancer through an AXL kinase pathway. Bioorganic and Medicinal Chemistry Letters 2014. PMID 25131538
• Novel Insights into the Mechanism of Inhibition of MmpL3, a Target of Multiple Pharmacophores in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy 2014. PMID 25136022
• Removal of the Iodinated X‑ray Contrast Medium Diatrizoate by Anaerobic Transformation. Environmental Science and Technology 2014. PMID 25140788
• In Silico Identification of an Aryl Hydrocarbon Receptor Antagonist with Biological Activity In Vitro and In Vivo. Molecular Pharmacology 2014. PMID 25159092
• A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry. Nature Chemical Biology 2014. PMID 25174000
• Clostridium difficile has a single sortase, SrtB, that can be inhibited by small-molecule inhibitors.. BMC Microbiology 2014. PMID 25183427
• Identification of small molecule modulators of gene transcription with anticancer activity.. ACS Chemical Biology 2014. PMID 25188650
• Improving Detection of Rare Biological Events in High-Throughput Screens. Journal of Biomolecular Screening 2014. PMID 25190066
• Using triple-helix-forming Peptide nucleic acids for sequence-selective recognition of double-stranded RNA. Current Protocols in Nucleic Acid Chemistry 2014. PMID 25199637
• Novel resveratrol analogues attenuate renal ischemic injury in rats. Journal of Surgical Research 2014. PMID 25214260
• Novel Imidazoline Antimicrobial Scaffold That Inhibits DNA Replication with Activity against Mycobacteria and Drug Resistant Gram-Positive Cocci. ACS Chemical Biology 2014. PMID 25222597
• Reversible covalent inhibition of eEF-2K by carbonitriles. ChemBioChem 2014. PMID 25224652
• A Cell-Based High-Throughput Screen for Novel Chemical Inducers of Fetal Hemoglobin for Treatment of Hemoglobinopathies. PLoS ONE 2014. PMID 25225870
• Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.. Journal of Medicinal Chemistry 2014. PMID 25226236
• Vesicular Trafficking of Incoming Human Papillomavirus 16 to the Golgi Apparatus and Endoplasmic Reticulum Requires -Secretase Activity. mBio 2014. PMID 25227470
• Intestinal Scavenger Receptors Are Involved in Vitamin K1 Absorption. Journal of Biological Chemistry 2014. PMID 25228690
• Discovery of a small molecule that inhibits bacterial ribosome biogenesis. eLife 2014. PMID 25233066
• Assessing an Ensemble Docking-Based Virtual Screening Strategy for Kinase Targets by Considering Protein Flexibility. Journal of Chemical Information and Modeling 2014. PMID 25233367
• Recent advances in structure-based drug design and virtual screening of VEGFR tyrosine kinase inhibitors. Methods 2014. PMID 25239735
• Discovery of inhibitors of Schistosoma mansoni HDAC8 by combining homology modeling, virtual screening, and in vitro validation.. Journal of Chemical Information and Modeling 2014. PMID 25243797
• Drug-Like Protein-Protein Interaction Modulators: Challenges and Opportunities for Drug Discovery and Chemical Biology. Molecular Informatics 2014. PMID 25254076
• Identification of a Novel Inhibitor of Dengue Virus Protease through Use of a Virtual Screening Drug Discovery Web Portal. Journal of Chemical Information and Modeling 2014. PMID 25263519
• A Male and Female Gametocyte Functional Viability Assay To Identify Biologically Relevant Malaria Transmission-Blocking Drugs. Antimicrobial Agents and Chemotherapy 2014. PMID 25267664
• Inhibitors of Nucleotidyltransferase Superfamily Enzymes Suppress Herpes Simplex Virus Replication. Antimicrobial Agents and Chemotherapy 2014. PMID 25267681
• Designing novel building blocks is an overlooked strategy to improve compound quality. Drug Discovery Today 2014. PMID 25281855
• Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation. Nature Immunology 2014. PMID 25282160
• Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to enzymes of a similar scaffold or mechanism. Bioorganic and Medicinal Chemistry Journal 2014. PMID 25282647
• Role of transient receptor potential and pannexin channels in cigarette smoke-triggered ATP release in the lung. Thorax 2014. PMID 25301060
• Inhibition of Salmonella enterica Biofilm Formation Using Small- Molecule Adenosine Mimetics. Antimicrobial Agents and Chemotherapy 2014. PMID 25313216
• Formation of a Protein Corona on Silver Nanoparticles Mediates Cellular Toxicity via Scavenger Receptors. Toxicological Sciences 2014. PMID 25326241
• Drug Strategies Targeting CYP51 in Neglected Tropical Diseases. Chemical Reviews 2014. PMID 25337991
• Cellular manganese content is developmentally regulated in human dopaminergic neurons. Scientific Reports 2014. PMID 25348053
• SREBP-1 is a novel mediator of TGFβ1 signaling in mesangial cells. Journal of Molecular Cell Biology 2014. PMID 25348957
• High-Throughput Screening Platform Identifies Small Molecules That Prevent Sequestration of Plasmodium falciparum–Infected Erythrocytes. The Journal of Infectious Diseases 2014. PMID 25355939
• [2]Pseudorotaxanes and [2]Catenanes Constructed by Oxacalixcrowns/Viologen Molecular Recognition Motifs. Organic Letters 2014. PMID 25365579
• Distant Polypharmacology among MLP Chemical Probes. ACS Chemical Biology 2014. PMID 25365788
• Imidazopyridine- and Purine-Thioacetamide Derivatives: Potent Inhibitors of Nucleotide Pyrophosphatase/Phosphodiesterase 1 (NPP1). Journal of Medicinal Chemistry 2014. PMID 25372276
• Mitochondrial Aldehyde Dehydrogenase Activation by Alda-1 Inhibits Atherosclerosis and Attenuates Hepatic Steatosis in Apolipoprotein E-Knockout Mice. Journal of the American Heart Association 2014. PMID 25392542
• Identifying modulators of CXC receptors 3 and 4 with tailored selectivity using multi-target docking.. ACS Chemical Biology 2014. PMID 25398025
• SREBP-1 Mediates Angiotensin II-Induced TGF-b1 Upregulation and Glomerular Fibrosis. Journal of the American Society of Nephrology 2014. PMID 25398788
• Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nature Cell Biology 2014. PMID 25402683
• Characterization of the Anopheles gambiae octopamine receptor and discovery of potential agonists and antagonists using a combined computational-experimental approach.. Malaria Journal 2014. PMID 25407998
• Anticancer/Antiviral Agent Akt Inhibitor-IV Massively Accumulates in Mitochondria and Potently Disrupts Cellular Bioenergetics. ACS Chemical Biology 2014. PMID 25415586
• Simultaneously Targeting Tissue Transglutaminase and Kidney Type Glutaminase Sensitizes Cancer Cells to Acid Toxicity and Offers New Opportunities for Therapeutic Intervention. Molecular Pharmaceutics 2014. PMID 25426679
• Discovery of thienoquinolone derivatives as selective and ATP non-competitive CDK5/p25 inhibitors by structure-based virtual screening. Bioorganic and Medicinal Chemistry Journal 2014. PMID 25438765
• Structure based virtual screening to discover putative drug candidates: Necessary considerations and successful case studies. Methods 2014. PMID 25448480
• Antagonism of human formyl peptide receptor 1 (FPR1) by chromones and related isoflavones. Biochemical Pharmacology 2014. PMID 25450672
• Identification and characterization of an anti-pseudomonal dichlorocarbazol derivative displaying anti-biofilm activity. Bioorganic and Medicinal Chemistry Letters 2014. PMID 25453797
• Towards novel therapeutics for HIV through fragment-based screening and drug design. Progress in Biophysics and Molecular Biology 2014. PMID 25455312
• Influence of physicochemical properties of silver nanoparticles on mast cell activation and degranulation. Toxicology in Vitro 2014. PMID 25458489
• 15 years of zebrafish chemical screening. Current Opinion in Chemical Biology 2014. PMID 25461724
• Methods for generating and applying pharmacophore models as virtual screening filters and for bioactivity profiling. Methods 2014. PMID 25461773
• Targeting homologous recombination, new pre-clinical and clinical therapeutic combinations inhibiting RAD51. Cancer Treatment Reviews 2014. PMID 25467108
• A new class of salicylic acid derivatives for inhibiting YopH of Yersinia pestis. Bioorganic and Medicinal Chemistry Journal 2014. PMID 25468042
• In Silico Design of Beta-Secretase Inhibitors in Alzheimer's Disease. Chemical Biology and Drug Design 2014. PMID 25476252
• C3larvin Toxin, an ADP-ribosyltransferase from Paenibacillus larvae*. Journal of Biological Chemistry 2014. PMID 25477523
• Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2- yl]carbonyl}-L-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2. Bioorganic and Medicinal Chemistry Letters 2014. PMID 25499438
• Identification of b-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity. International Journal for Parasitology - Drugs and Drug Resistance 2014. PMID 25516843
• A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. Proceedings of the National Academy of Sciences 2014. PMID 25518860
• Discovery of mono- and disubstituted 1H-pyrazolo[3,4]pyrimidines and 9H-purines as catalytic inhibitors of human DNA topoisomerase II. ChemMedChem 2014. PMID 25522133
• Acetate Dependence of Tumors. Cell 2014. PMID 25525877
• Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response.. ACS Medicinal Chemistry Letters 2014. PMID 25530830
• Design, synthesis, and biological evaluation of aminothiazole derivatives against the fungal pathogens Histoplasma capsulatum and Cryptococcus neoformans. Bioorganic and Medicinal Chemistry Journal 2014. PMID 25543205
• Identification and optimization of Escherichia coli GlmU inhibitors: An in silico approach with validation thereof. European Journal of Medicinal Chemistry 2014. PMID 25544688
• Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Proceedings of the National Academy of Sciences 2014. PMID 25548170
• Pharmacological activation of myosin II paralogs to correct cell mechanics defects. Proceedings of the National Academy of Sciences 2014. PMID 25605895
• Pharmacophore Modeling, Ensemble Docking, Virtual Screening, and Biological Evaluation on Glycogen Synthase Kinase-3beta. Molecular Informatics 2014. PMID 27486080
• Quantitative Structure-Activity Relationship Analysis and a Combined Ligand-Based/Structure-Based Virtual Screening Study for Glycogen Synthase Kinase-3. Molecular Informatics 2014. PMID 27486081
• Theoretical study of the inclusion processes of octopamine with β-cyclodextrin: PM6, ONIOM, and NBO analysis. Comptes Rendu Chimie 2014. PMID N/A
• Design, synthesis and evaluation of 2-(4-(substituted benzoyl)-1,4-diazepan-1-yl)- N-phenylacetamide derivatives as a new class of falcipain-2 inhibitors. Arabian Journal of Chemistry 2014. PMID N/A
• Six-Membered Ring Systems: Diazines and Benzo Derivatives. Book Chapter 2014. PMID N/A
• Cp2ZrCl2-catalyzed synthesis of 2-aminovinyl benzimidazoles under microwave conditions. Chinese Chemical Letters 2014. PMID N/A
• Combinatorial Chemistry Online Volume 16, Issue 11, November 2014. Combinatorial Chemistry Online 2014. PMID N/A
• Pharmacophore-based design, synthesis, and biological evaluation of novel 3-((3,4-dichlorophenyl)(4-substituted benzyl)amino) propanamides as cholesteryl ester transfer protein (CETP) inhibitors. Chinese Chemical Letters 2014. PMID N/A
• 1,8-Dioxyanthracene-Derived Crown Ethers: Synthesis, Complexation with Paraquat and Assembly of a Tetracationic Cyclophane-Crown Ether Based [2]Catenane. European Journal of Organic Chemistry 2014. PMID N/A
• Chemical Biology in Plants: Finding New Connections between Pathways Using the Small Molecule Sortin1. Book Chapter 2014. PMID N/A
• Confirmation of predicted activity for factor XIa inhibitors from a virtual screening approach. AIChE Journal 2014. PMID N/A
• The Valence Bond Perspective of the Chemical Bond. Book Chapter 2014. PMID N/A
• Therapeutic Targeting of the Wnt Signaling Network. Book Chapter 2014. PMID N/A
• Using Chemical Genomics to Study Cell Wall Formation and Cell Growth in Arabidopsis thaliana and Penium margaritaceum. Other 2014. PMID
• A 30W 800 MHz complimentary LDMOS power amplifier for wireless application. Superlattices and Microstructures 2014. PMID
• Identification and validation of P. berghei glutathione s-transferase small molecule inhibitors by virtual library screening (LB274). The FASEB Journal 2014. PMID
• Theoretical approaches to identify the potent scaffold for human sirtuin1 activator: Bayesian modeling and density functional theory.. Medicinal Chemistry Research 2014. PMID
• Basic Chemistry of Botulinum Neurotoxins Relevant to Vaccines, Diagnostics, and Countermeasures.. Book Chapter 2014. PMID
• Effect of anion on Ag(I) meso-helical chains formed with 4,4'-dipyridyl ketone: solvent versus anion bridging and anion effects on the strength of ligand binding. CrystEngComm 2014. PMID
• Prevention and Treatment of Botulism.. Book Chapter 2014. PMID
• Optimization of compound ranking for structure-based virtual ligand screening using an established FRED-Surflex consensus approach. Chemical Biology and Drug Design 2013. PMID 2394146
• Synthesis of silicon-functionalized dibenzosilaborins by intramolecular B-H/C-H dehydrogenative cyclization and their tunable photophysical and chemical properties by silyl groups. Chemistry - A European Journal 2013. PMID 2402700
• Gaining Insights Into the Small Molecule Targeting of the G-quadruplex in the c-MYC Promoter Using NMR and an Allele-Specific Transcriptional Assay. Other 2013. PMID 22752577
• BD750, a benzothiazole derivative, inhibits T cell proliferation by affecting the JAK3/STAT5 signalling pathway. British Journal of Pharmacology 2013. PMID 22906008
• High-Throughput FRET Assay Yields Allosteric SERCA Activators. Journal of Biomolecular Screening 2013. PMID 22923787
• A Fluorescent-Based High-Throughput Screening Assay for Small Molecules That Inhibit the Interaction of MdmX with p53. Journal of Biomolecular Screening 2013. PMID 22989451
• Identification of small molecule Hes1 modulators as potential anticancer chemotherapeutics. Chemical Biology and Drug Design 2013. PMID 23006776
• Discovery of Potent Inhibitors for interleukin-2-inducible T-cell Kinase: Structure-Based Virtual Screening and Molecular Dynamics Simulation Approaches. Other 2013. PMID 23015102
• RNA-seq analysis identifies potential modulators of gravity response in spores of Ceratopteris (Parkeriaceae): evidence for modulation by calcium pumps and apyrase activity.. American Journal of Botany 2013. PMID 23048014
• Identification of Hedgehog pathway responsive glioblastomas by isocitrate dehydrogenase mutation. Cancer Letters 2013. PMID 23063752
• A Novel Inhibitor of Dengue Virus Replication That Targets the Capsid Protein. Antimicrobial Agents and Chemotherapy 2013. PMID 23070172
• Discovery of novel cannabinoid receptor ligands by a virtual screening approach: Further development of 2,4,6-trisubstituted 1,3,5-triazines as CB2 agonists. European Journal of Pharmaceutical Sciences 2013. PMID 23131798
• Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology. Journal of Medicinal Chemistry 2013. PMID 23145854
• The exocyst complex contributes to PIN auxin efflux carrier recycling and polar auxin transport in Arabidopsis. The Plant Journal 2013. PMID 23163883
• Ovarian granulosa cells utilize scavenger receptor SR-BI to evade cellular cholesterol homeostatic control for steroid synthesis . Journal of Lipid Research 2013. PMID 23197320
• Broad Coverage of Commercially Available Lead-like Screening Space with Fewer than 350,000 Compounds. Journal of Chemical Information and Modeling 2013. PMID 23198812
• Virtual Screening of CB2 Receptor Agonists from Bayesian Network and High-Throughput Docking: Structural Insights into Agonist-Modulated GPCR Features. Chemical Biology and Drug Design 2013. PMID 23217060
• Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response.. Molecular Pharmacology 2013. PMID 23229510
• An Optimized RAD51 Inhibitor That Disrupts Homologous Recombination without Requiring Michael Acceptor Reactivity. Journal of Medicinal Chemistry 2013. PMID 23231413
• Discovery of Novel Antimalarial Compounds Enabled by QSAR-Based Virtual Screening. Journal of Chemical Information and Modeling 2013. PMID 23252936
• Copper-Boosting Compounds: a Novel Concept for Antimycobacterial Drug Discovery. Antimicrobial Agents and Chemotherapy 2013. PMID 23254420
• Superoxide generation and leukocyte accumulation: key elements in the mediation of leukotriene Bâ‚„-induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1.. The FASEB Journal 2013. PMID 23271050
• Identification of Novel Androgen Receptor Antagonists Using Structure- and Ligand-Based Methods. Journal of Chemical Information and Modeling 2013. PMID 23278403
• Dissociated modulation of conditioned place-preference and mechanical hypersensitivity by a TRPA1 channel antagonist in peripheral neuropathy. Pharmacoloy, Biochemistry and Behavior 2013. PMID 23287802
• Phenyl-Adenine, Identified in a LIGHT-DEPENDENT SHORT HYPOCOTYLS4-Assisted Chemical Screen, Is a Potent Compound for Shoot Regeneration through the Inhibition of CYTOKININ OXIDASE/DEHYDROGENASE Activity. Plant Physiology 2013. PMID 23288884
• Blockade of Insect Odorant Receptor Currents by Amiloride Derivatives. Chemical Senses 2013. PMID 23292750
• High-Throughput Screening of Small Molecules Identifies Hepcidin Antagonists. Molecular Pharmacology 2013. PMID 23292796
• Small-molecule Screens to Study Lateral Root Development. Other 2013. PMID 23299676
• Anatomical and functional characterization of a duodeno-pancreatic neural reflex that can induce acute pancreatitis. American Journal of Physiology - Gastrointestinal and Liver Physiology 2013. PMID 23306082
• Tenovin-D3, a novel small-molecule inhibitor of sirtuin SirT2, increases p21 (CDKN1A) expression in a p53-independent manner.. Molecular Cancer Therapeutics 2013. PMID 23322738
• BioSM: Metabolomics Tool for Identifying Endogenous Mammalian Biochemical Structures in Chemical Structure Space. Journal of Chemical Information and Modeling 2013. PMID 23330685
• The role of NF-кB in SAA-induced peroxisome proliferator-activated receptor g activation. Atherosclerosis 2013. PMID 23340376
• Biomimetic, synthetic HDL nanostructures for lymphoma. Proceedings of the National Academy of Sciences 2013. PMID 23345442
• In silico identification of novel inhibitors against Plasmodium falciparum dihydroorate dehydrogenase. Journal of Molecular Graphics and Modelling 2013. PMID 23353582
• Role of ubiquitin ligases and the proteasome in oncogenesis: novel targets for anticancer therapies.. Journal of Clinical Oncology 2013. PMID 23358974
• Identification of a Small-Molecule Inhibitor of Bacterial AraC Family Activators. Journal of Biomolecular Screening 2013. PMID 23364515
• Development of a robust luciferase reporter 1b/2a hepatitis C virus (HCV) for characterization of early stage HCV life cycle inhibitors. Antiviral Research 2013. PMID 23376631
• Small Molecule Antivirulents Targeting the Iron-Regulated Heme Oxygenase (HemO) of P. aeruginosa. Journal of Medicinal Chemistry 2013. PMID 23379514
• TFEB regulates lysosomal proteostasis. Human Molecular Genetics 2013. PMID 23393155
• Photochemical activation of TRPA1 channels in neurons and animals.. Nature Chemical Biology 2013. PMID 23396078
• Site-Specific and Regiospecific Installation of Methylarginine Analogues into Recombinant Histones and Insights into Effector Protein Binding. Journal of the American Chemical Society 2013. PMID 23398247
• Small molecule inhibitor of lipoteichoic acid synthesis is an antibiotic for Gram-positive bacteria. Proceedings of the National Academy of Sciences 2013. PMID 23401520
• Novel benzoxazole inhibitor of dengue virus replication that targets the NS3 helicase. Antimicrobial Agents and Chemotherapy 2013. PMID 23403421
• A Cell-Based Screening Platform Identifies Novel Mosquitocidal Toxins. Journal of Biomolecular Screening 2013. PMID 23407365
• Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen.. Journal of Biological Chemistry 2013. PMID 23408432
• A rational free energy-based approach to understanding and targeting disease-causing missense mutations.. Journal of American Medical Information Association 2013. PMID 23408511
• Discovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal Structure. Journal of Medicinal Chemistry 2013. PMID 23409953
• Identification and characterization of bi-thiazole-2,2′-diamines as kinase inhibitory scaffolds. Biochimica et Biophysica Acta 2013. PMID 23410953
• Monoclonal Antibodies With Group Specificity Toward Sulfonamides: Selection of Hapten and Antibody Selectivity. Other 2013. PMID 23417550
• Rational discovery of dengue type 2 non-competitive inhibitors. Chemical Biology and Drug Design 2013. PMID 23421589
• Plasmodium yoelii inhibitor of cysteine proteases is exported to exomembrane structures and interacts with yoelipain-2 during asexual blood-stage development. Cellular Microbiology 2013. PMID 23421981
• Drug discovery: Diversifying complexity.. Nature Chemistry 2013. PMID 23422555
• A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products.. Nature Chemistry 2013. PMID 23422561
• CD36 and SR-BI are involved in cellular uptake of provitamin A carotenoids by Caco-2 and HEK cells, and some of their genetic variants are associated with plasma concentrations of these micronutrients in humans.. The Journal of Nutrition 2013. PMID 23427331
• 6-Oxo and 6-Thio Purine Analogs as Antimycobacterial Agents . Bioorganic and Medicinal Chemistry Journal 2013. PMID 23434367
• An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity.. Cancer Research 2013. PMID 23440422
• Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E2 synthesis in vitro and ameliorates experimental periodontitis in vivo.. The FASEB Journal 2013. PMID 23447581
• Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened.. Molecular Pharmacology 2013. PMID 23448715
• Cerebrovascular dilation via selective targeting of the cholane steroid-recognition site in the BK channel β1-subunit by a novel nonsteroidal agent.. Journal of Molecular Pharmacology 2013. PMID 23455312
• Discovery of biologically active oncologic and immunologic small molecule therapies using zebrafish: overview and example of modulation of T cell activation. Current Protocols in Pharmacology 2013. PMID 23456612
• Discovery of a Novel Selective Kappa-Opioid Receptor Agonist Using Crystal Structure-Based Virtual Screening. Journal of Chemical Information and Modeling 2013. PMID 23461591
• The Development of Highly Potent Inhibitors for Porcupine. Journal of Medicinal Chemistry 2013. PMID 23477365
• Role of macrophage activation in the lipid metabolism of postprandial triacylglycerol-rich lipoproteins. Experimental Biology and Medicine 2013. PMID 23479769
• Intestinal Bile Secretion Promotes Drug Absorption from Lipid Colloidal Phases via Induction of Supersaturation. Molecular Pharmaceutics 2013. PMID 23480483
• Small Molecule Screen Reveals Regulation of Survival Motor Neuron Protein Abundance by Ras Proteins. ACS Chemical Biology 2013. PMID 23496866
• Feasibility of Using Molecular Docking-Based Virtual Screening for Searching Dual Target Kinase Inhibitors. Journal of Chemical Information and Modeling 2013. PMID 23506306
• Biophysical Fragment Screening of the Beta1-Adrenergic Receptor: Identification of High Affinity Arylpiperazine Leads Using Structure-Based Drug Design. Journal of Medicinal Chemistry 2013. PMID 23517028
• Chemical screening methods for flagellar phenotypes in Chlamydomonas.. Methods in Enzymology 2013. PMID 23522478
• Latest developments in molecular docking: 2010–2011 in review. Journal of Molecular Recognition 2013. PMID 23526775
• Discovery of Highly Potent Microsomal Prostaglandin E2 Synthase 1 Inhibitors Using the Active Conformation Structural Model and Virtual Screen. Journal of Medicinal Chemistry 2013. PMID 23527738
• Phenothiazines inhibit hepatitis C virus entry, likely by increasing the fluidity of cholesterol-rich membranes.. Antimicrobial Agents and Chemotherapy 2013. PMID 23529728
• Discovery of the novel mTOR inhibitor and its antitumor activities in vitro and in vivo.. Molecular Cancer Therapeutics 2013. PMID 23536724
• Structure-Based Virtual Screening of MT2 Melatonin Receptor: Influence of Template Choice and Structural Refinement. Journal of Chemical Information and Modeling 2013. PMID 23541165
• Oxadiazole-isopropylamides as Potent and Noncovalent Proteasome Inhibitors. Journal of Medicinal Chemistry 2013. PMID 23547706
• Identification of novel SIRT3 inhibitor scaffolds by virtual screening.. Bioorganic and Medicinal Chemistry Letters 2013. PMID 23562596
• Targeting Mutant KRAS for Anticancer Therapeutics: A Review of Novel Small Molecule Modulators. Journal of Medicinal Chemistry 2013. PMID 23566315
• Synthesis and structure-activity relationships of 2-amino-3-carboxy-4-phenyl‐thiophenes as novel atypical protein kinase C inhibitors. Bioorganic and Medicinal Chemistry Letters 2013. PMID 23566515
• Rational Design of HIV-1 Entry Inhibitors. Other 2013. PMID 23568472
• What can we learn from the microbial ecological interactions associated with polymicrobial diseases?. Veterinary Immunology and Immunopathology 2013. PMID 23570991
• Paraoxonase 1 (PON1) reduces macrophage inflammatory responses.. Atherosclerosis 2013. PMID 23582715
• Identification and Validation of a Selective Small Molecule Inhibitor Targeting the Diacylglycerol Acyltransferase 2 Activity. Biological and Pharmaceutical Bulletin 2013. PMID 23585481
• Identification of a Small Molecule that induces ATG5-and- Cathepsin-L-Dependent Cell Death and modulates Polyglutamine Toxicity. Experimental Cell Research 2013. PMID 23588206
• Inhibition of Melanoma Growth by Small Molecules That Promote the Mitochondrial Localization of ATF2. Clinical Cancer Research 2013. PMID 23589174
• CamMedNP: building the Cameroonian 3D structural natural products database for virtual screening.. BMC Complementary and Alternative Medicine 2013. PMID 23590173
• A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo.. Science Translational Medicine 2013. PMID 23596204
• A small molecule inhibitor of redox-regulated protein translocation into mitochondria.. Developmental Cell 2013. PMID 23597483
• Iron modulates cell survival in a Ras- and MAPK-dependent manner in ovarian cells.. Cell Death and Disease 2013. PMID 23598404
• Identification of Compounds with Potential Antibacterial Activity against Mycobacterium through Structure-Based Drug Screening. Journal of Chemical Information and Modeling 2013. PMID 23600706
• Discovery of a new bioactive molecule for neuroblastoma. Chemical Biology and Drug Design 2013. PMID 23601248
• Screening for inhibitors of the hepatitis C virus internal ribosome entry site RNA . Bioorganic and Medicinal Chemistry Journal 2013. PMID 23602522
• Anle138b: A Novel Oligomer Modulator for Disease-Modifying Therapy of Neurodegenerative Diseases Such as Prion and Parkinson's Disease. Other 2013. PMID 23604588
• A High-Throughput Screen of the GTPase Activity of Escherichia coli EngA to Find an Inhibitor of Bacterial Ribosome Biogenesis.. Journal of Biomolecular Screening 2013. PMID 23606650
• CSAR Data Set Release 2012: Ligands, Affinities, Complexes, and Docking Decoys. Journal of Chemical Information and Modeling 2013. PMID 23617227
• Imaging the cytosolic drug delivery mechanism of HDL-like nanoparticles.. Pharmaceutical Research 2013. PMID 23625096
• The Ah receptor regulates growth factor expression in head and neck squamous cell carcinoma cell lines. Molecular Carcinogenesis 2013. PMID 23625689
• Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents.. Molecular Cancer Therapeutics 2013. PMID 23625935
• Activation of heme biosynthesis by a small molecule that is toxic to fermenting Staphylococcus aureus.. Proceedings of the National Academy of Sciences 2013. PMID 23630262
• GIRK-like and TRPC-like conductances mediate thyrotropin-releasing hormone-induced increases in excitability in thalamic paraventricular nucleus neurons. Neuropharmacology 2013. PMID 23632082
• Inauhzin Sensitizes p53-Dependent Cytotoxicity and Tumor Suppression of Chemotherapeutic Agents. Neoplasia 2013. PMID 23633924
• A novel quinoline derivative that inhibits mycobacterial FtsZ.. Tuberculosis 2013. PMID 23647650
• Structure-based discovery of antagonists of nuclear receptor LRH-1. Journal of Biological Chemistry 2013. PMID 23667258
• Optimization of Benzoxazole-Based Inhibitors of Cryptosporidium parvum Inosine 5'-Monophosphate Dehydrogenase. Journal of Medicinal Chemistry 2013. PMID 23668331
• Characterization of antiviral activity of benzamide derivative AH0109 against HIV-1 infection.. Antimicrobial Agents and Chemotherapy 2013. PMID 23669388
• Scaffold-Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitors. Journal of Chemical Information and Modeling 2013. PMID 23672464
• Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer.. Molecular Cancer Therapeutics 2013. PMID 23674815
• Identification of M. tuberculosis Thioredoxin Reductase Inhibitors Based on High-Throughput Docking Using Constraints. Journal of Medicinal Chemistry 2013. PMID 23676086
• An optogenetic tool for the activation of endogenous diaphanous-related formins induces thickening of stress fibers without an increase in contractility. Cytoskeleton 2013. PMID 23677607
• Activation of the B Cell Antigen Receptor Triggers Reactivation of Latent Kaposi's Sarcoma-Associated Herpesvirus in B Cells.. Journal of Virology 2013. PMID 23678173
• Potentiation of Azole Antifungals by 2-Adamantanamine. Antimicrobial Agents and Chemotherapy 2013. PMID 23689724
• Discovery of Staphylococcus aureus sortase A inhibitors using virtual screening and the relaxed complex scheme. Chemical Biology and Drug Design 2013. PMID 23701677
• Integrating Intramolecular Hydrogen Bonding (IMHB) Considerations in Drug Discovery Using delta logP As a Tool. Journal of Medicinal Chemistry 2013. PMID 23710574
• Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nature Chemical Biology 2013. PMID 23728495
• Structure-based Virtual Screening for Novel Ligands. Other 2013. PMID 23729265
• A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2P Channels. ACS Chemical Biology 2013. PMID 23738709
• Selective inhibition of PCAF suppresses microglial-mediated β-amyloid neurotoxicity. International Journal of Molecular Medicine 2013. PMID 23740527
• Benzylmorpholine Analogs as Selective Inhibitors of Lung Cytochrome P450 2A13 for the Chemoprevention of Lung Cancer in Tobacco Users. Pharmaceutical Research 2013. PMID 23756756
• Discovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: pharmacophore modeling and structure-activity relationship studies.. Bioorganic and Medicinal Chemistry Journal 2013. PMID 23757208
• Modeling Compound-Target Interaction Network of Traditional Chinese Medicines for Type II Diabetes Mellitus: Insight for Polypharmacology and Drug Design. Journal of Chemical Information and Modeling 2013. PMID 23768230
• A colorimetric assay optimization for high-throughput screening of dihydroorotase by detecting ureido groups.. Analytical Biochemistry 2013. PMID 23769705
• Development of specific dengue virus 2\'-O- and N7-methyltransferase assays for antiviral drug screening.. Antiviral Research 2013. PMID 23769894
• Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis. Nature Chemical Biology 2013. PMID 23770708
• From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead molecules. ChemMedChem 2013. PMID 23776181
• Murine mPGES-1 3D Structure Elucidation and Inhibitors Binding Mode Predictions by Homology Modeling and Site-Directed Mutagenesis. Journal of Chemical Information and Modeling 2013. PMID 23789712
• Juxtaposition of chemical and mutation-induced developmental defects in zebrafish reveal a copper-chelating activity for kalihinol F.. Chemistry and Biology 2013. PMID 23790486
• Discovery of a subtype selective inhibitor of the human betaine/GABA transporter 1 (BGT-1) with a non-competitive pharmacological profile.. Biochemical Pharmacology 2013. PMID 23792119
• Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.. Molecular Pharmacology 2013. PMID 23793291
• The influenza virus NS1 protein as a therapeutic target.. Antiviral Research 2013. PMID 23796981
• High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury. Toxicology and Applied Pharmacology 2013. PMID 23811330
• Mitochondrial membrane permeabilisation by amyloid aggregates and protection by polyphenols.. Biochimica et Biophysica Acta 2013. PMID 23817009
• Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity. Proceedings of the National Academy of Sciences 2013. PMID 23818586
• Activation of dimeric ABA receptors elicits guard cell closure, ABA-regulated gene expression, and drought tolerance.. Proceedings of the National Academy of Sciences 2013. PMID 23818638
• Concurrent agonism of adenosine A2B and glucocorticoid receptors in human airway epithelial cells cooperatively induces genes with anti-inflammatory potential: a novel approach to treat chronic obstructive pulmonary disease.. Journal of Pharmacology and Experimental Therapeutics 2013. PMID 23820127
• Inhibitory and combinatorial effect of diphyllin, a v-ATPase blocker, on influenza viruses. Antiviral Research 2013. PMID 23820269
• Lovastatin-induced apoptosis is mediated by activating transcription factor 3 and enhanced in combination with salubrinal. International Journal of Cancer 2013. PMID 23824972
• The Discovery of PLK4 Inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as Novel Antiproliferative Agents. Journal of Medicinal Chemistry 2013. PMID 23829549
• Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1.. Journal of Biological Chemistry 2013. PMID 23839987
• Inhibitors of Bacillus anthracis edema factor. Pharmacology and Therapeutics 2013. PMID 23850654
• Stimulation of Phagocyte Adhesion to Endothelial Cells by Modified VLDL and HDL Requires Scavenger Receptor BI. Other 2013. PMID 23852455
• A requirement for fatty acid oxidation in the hormone-induced meiotic maturation of mouse oocytes. Biology of Reproduction 2013. PMID 23863407
• Chapter Six – FOXM1 (Forkhead box M1) in Tumorigenesis: Overexpression in Human Cancer, Implication in Tumorigenesis, Oncogenic Functions, Tumor-Suppressive Properties, and Target of Anticancer Therapy. Advances in Cancer Research 2013. PMID 23870513
• Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta.. eLife 2013. PMID 23878726
• Resistance to EGFR-TKI can be mediated through multiple signaling pathways converging upon cap-dependent translation in EGFR-wild type NSCLC. Journal of Thoracic Oncology 2013. PMID 23883783
• Topical Antiangiogenic SRPK1 Inhibitors Reduce Choroidal Neovascularization in Rodent Models of Exudative AMD. Investigative Ophthalmology and Visual Science 2013. PMID 23887803
• Muscarinic Receptors as Model Targets and Antitargets for Structure-Based Ligand Discovery. Molecular Pharmacology 2013. PMID 23887926
• S1 pocket of glutamate carboxypeptidase II: A new binding site for amyloid-β degradation. Biochemical and Biophysical Research Communications 2013. PMID 23891752
• Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis. Proceedings of the National Academy of Sciences 2013. PMID 23904484
• Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression. Cell 2013. PMID 23911321
• Small-molecule inhibitors suppress the expression of both type III secretion and amylovoran biosynthesis genes in Erwinia amylovora. Molecular Plant 2013. PMID 23915008
• A Trigonal Prismatic Ligand in the Metal-Mediated Self-Assembly of One- and Two-Dimensional Metallosupramolecular Polymers. Inorganic Chemistry 2013. PMID 23927581
• In silico optimization of a fragment-based hit yields biologically active, high-efficiency inhibitors for glutamate racemase. ChemMedChem 2013. PMID 23929705
• Advancement of Imidazo[1,2-a]pyridines with Improved Pharmacokinetics and nM Activity vs. Mycobacterium tuberculosis. ACS Medicinal Chemistry Letters 2013. PMID 23930153
• Identification of fragments targeting an alternative pocket on HIV-1 gp41 by NMR screening and similarity searching.. Bioorganic and Medicinal Chemistry Letters 2013. PMID 23932360
• A GAA repeat expansion reporter model of Friedreich\'s ataxia recapitulates the genomic context and allows rapid screening of therapeutic compounds.. Human Molecular Genetics 2013. PMID 23943791
• Characterization of novel inhibitors of HIV-1 replication that function via alteration of viral RNA processing and rev function. Nucleic Acids Research 2013. PMID 23945945
• An isogenic cell panel identifies compounds that inhibit proliferation of mTOR-pathway addicted cells by different mechanisms.. Journal of Biomolecular Screening 2013. PMID 23954931
• From Determinants of RUNX1/ETO Tetramerization to Small-Molecule Protein-Protein Interaction Inhibitors Targeting Acute Myeloid Leukemia. Journal of Chemical Information and Modeling 2013. PMID 23957251
• Anti-obesity phenotypic screening looking to increase OBR cell surface expression.. Journal of Biomolecular Screening 2013. PMID 23958651
• Complementarity between in Silico and Biophysical Screening Approaches in Fragment-Based Lead Discovery against the A2A Adenosine Receptor. Journal of Chemical Information and Modeling 2013. PMID 23971943
• Structure-based discovery of antagonists for GluN3-containing N-methyl-D-aspartate receptors. Neuropharmacology 2013. PMID 23973313
• Small-molecule antagonists of melanopsin-mediated phototransduction. Nature Chemical Biology 2013. PMID 23974117
• A Bidirectional System for the Dynamic Small Molecule Control of Intracellular Fusion Proteins. ACS Chemical Biology 2013. PMID 23978068
• Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy. Biochemical Journal 2013. PMID 23981180
• Targeting of tonoplast proteins to the vacuole. Plant Science 2013. PMID 23987818
• Discovery of thiazolyl-phthalazinone acetamides as potent glucose uptake activators via high-throughput screening.. Bioorganic and Medicinal Chemistry Letters 2013. PMID 23992862
• Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening.. Free Radical Biology and Medicine 2013. PMID 23994103
• Identification of Five Structurally Unrelated Quorum-Sensing Inhibitors of Pseudomonas aeruginosa from a Natural-Derivative Database. Antimicrobial Agents and Chemotherapy 2013. PMID 24002091
• Isoform Selectivity of Adenylyl Cyclase Inhibitors: Characterization of Known and Novel Compounds. Journal of Pharmacology and Experimental Therapeutics 2013. PMID 24006339
• Development and Evaluation of an Integrated Virtual Screening Strategy by Combining Molecular Docking and Pharmacophore Searching Based on Multiple Protein Structures. Journal of Chemical Information and Modeling 2013. PMID 24010823
• Inhibitors of the aminoglycoside 6\'-N-acetyltransferase type Ib [AAC(6\')-Ib] identified by in silico molecular docking. Bioorganic and Medicinal Chemistry Letters 2013. PMID 24011645
• New chemotypes for wALADin1-like inhibitors of delta-aminolevulinic acid dehydratase from Wolbachia endobacteria.. Bioorganic and Medicinal Chemistry Letters 2013. PMID 24012123
• Computational and experimental analysis of drug binding to the Influenza M2 channel.. Biochimica et Biophysica Acta 2013. PMID 24016551
• A High-Content Screen Identifies Novel Compounds That Inhibit Stress-Induced TDP-43 Cellular Aggregation and Associated Cytotoxicity. Journal of Biomolecular Screening 2013. PMID 24019256
• Disarming Bacterial Virulence through Chemical Inhibition of the DNA Binding Domain of an AraC-like Transcriptional Activator Protein . Journal of Biological Chemistry 2013. PMID 24019519
• Structure-Based Ligand Discovery Targeting Orthosteric and Allosteric Pockets of Dopamine Receptors. Molecular Pharmacology 2013. PMID 24021214
• Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis. Traffic 2013. PMID 24025110
• Identification of novel small compounds that restore E-cadherin expression and inhibit tumor cell motility and invasiveness. Biochemical Pharmacology 2013. PMID 24035834
• Inhibitors of SCF-Skp2/Cks1 E3 ligase block estrogen-induced growth stimulation and degradation of nuclear p27kip1: therapeutic potential for endometrial cancer.. Endocrinology 2013. PMID 24035998
• Inhibitors of SCF-Skp2/Cks1 E3 Ligase Block Estrogen- Induced Growth Stimulation and Degradation of Nuclear p27kip1: Therapeutic Potential for Endometrial Cancer. Endocrinology 2013. PMID 24035998
• Binding sites and hydrophobic pockets in Human Thioredoxin 1 determined by normal mode analysis. Journal of Structural Biology 2013. PMID 24036282
• Zebrafish-based small molecule screens for novel cardiovascular drugs. Drug Discovery Today 2013. PMID 24050238
• Structure-Activity Relationship Study of Indole-2-carboxamides Identifies a Potent Allosteric Modulator for the Cannabinoid Receptor 1 (CB1). Journal of Medicinal Chemistry 2013. PMID 24053617
• A large scale virtual screen of DprE1. Computational Biology and Chemistry 2013. PMID 24055764
• Structural Determinants of Tau Aggregation Inhibitor Potency . Journal of Biological Chemistry 2013. PMID 24072703
• Structure-based identification of novel PPAR gamma ligands.. Bioorganic and Medicinal Chemistry Letters 2013. PMID 24075729
• High-Throughput Screens for eEF-2 Kinase. Journal of Biomolecular Screening 2013. PMID 24078616
• Analysis of the local organization and dynamics of cellular actin networks. The Journal of Cell Biology 2013. PMID 24081490
• Development of a High-Throughput AlphaScreen Assay for Modulators of Synapsin I Phosphorylation in Primary Neurons. Journal of Biomolecular Screening 2013. PMID 24088370
• Odour receptors and neurons for DEET and new insect repellents. Nature 2013. PMID 24089210
• Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening. Journal of Medicinal Chemistry 2013. PMID 24090311
• TRPA1: a transducer and amplifier of pain and inflammation. Basic and Clinical Pharmacology and Toxicology 2013. PMID 24102997
• Cell-free unnatural amino acid incorporation with alternative energy systems and linear expression templates. Nature Biotechnology 2013. PMID 24103470
• Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate.. Malaria Journal 2013. PMID 24107123
• High-Throughput Fluorescence Anisotropy Screen for Inhibitors of the Oncogenic mRNA Binding Protein, IMP-1. Journal of Biomolecular Screening 2013. PMID 24108120
• Fragment-Based Identification of a Locus in the Sec7 Domain of Arno for the Design of Protein-Protein Interaction Inhibitors.. Journal of Medicinal Chemistry 2013. PMID 24112024
• Endoplasmic Reticulum-associated Degradation Controls Cell Surface Expression of g-Aminobutyric Acid, Type B Receptors. Journal of Biological Chemistry 2013. PMID 24114844
• Why are membrane targets discovered by phenotypic screens and genome sequencing in Mycobacterium tuberculosis?. Tuberculosis 2013. PMID 24119636
• Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation. Nature Chemical Biology 2013. PMID 24121552
• Development of an Ex Vivo Lymph Node Explant Model for Identification of Novel Molecules Active against Leishmania major . Antimicrobial Agents and Chemotherapy 2013. PMID 24126577
• para-Substituted 2-phenyl-3,4-dihydroquinazolin-4-ones as potent and selective tankyrase inhibitors. ChemMedChem 2013. PMID 24130191
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• A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing. Nature 2013. PMID 24141946
• Novel Antifungal Drug Discovery Based on Targeting Pathways Regulating the Fungus-Conserved Upc2 Transcription Factor . Antimicrobial Agents and Chemotherapy 2013. PMID 24145546
• Novel Anti-Plasmodial Hits Identified by Virtual Screening of the ZINC Database. Other 2013. PMID 24158745
• Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. Nature Chemical Biology 2013. PMID 24161946
• A specific cholesterol metabolic pathway is established in a subset of HCCs for tumor growth. Journal of Molecular Cell Biology 2013. PMID 24163426
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• High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines. Human Molecular Genetics 2013. PMID 24179176
• Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells.. Bioorganic and Medicinal Chemistry Journal 2013. PMID 24183589
• Next-Generation NAMPT Inhibitors Identified by Sequential High-Throughput Phenotypic Chemical and Functional Genomic Screens. Chemistry and Biology 2013. PMID 24183972
• Fish in a Dish: Drug Discovery for Hearing Habilitation. Drug Discovery Today 2013. PMID 24187569
• Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses. Proceedings of the National Academy of Sciences 2013. PMID 24191014
• 2P2I HUNTER: a tool for filtering orthosteric protein-protein interaction modulators via a dedicated support vector machine.. Journal of the Royal Society - Interface 2013. PMID 24196694
• Identification by in silico and in vitro screenings of small organic molecules acting as reversible inhibitors of kallikreins. European Journal of Medicinal Chemistry 2013. PMID 24211642
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• Rational design of small molecules targeting the C2 domain of coagulation factor VIII. Blood 2013. PMID 24227818
• Novel Neuroprotective GSK-3β Inhibitor Restricts Tat-Mediated HIV-1 Replication. Journal of Virology 2013. PMID 24227837
• Novel Neuroprotective GSK-3β Inhibitor Restricts Tat-Mediated HIV-1 Replication.. Journal of Virology 2013. PMID 24227837
• High-Throughput Virtual Screening Identifies Novel N′‑(1- Phenylethylidene)-benzohydrazides as Potent, Specific, and Reversible LSD1 Inhibitors. Journal of Medicinal Chemistry 2013. PMID 24237195
• Systematic Identification of Molecular Subtype-Selective Vulnerabilities in Non-Small-Cell Lung Cancer. Cell 2013. PMID 24243015
• A Type III Secretion System Inhibitor Targets YopD while Revealing DifferentialRegulation of Secretion in Calcium-Blind Mutants of Yersinia pestis. Antimicrobial Agents and Chemotherapy 2013. PMID 24247143
• Characterization of a Novel Pyranopyridine Inhibitor of the AcrAB Efflux Pump of Escherichia coli. Antimicrobial Agents and Chemotherapy 2013. PMID 24247144
• Auxin biology revealed by small molecules. Plant Physiology 2013. PMID 24252105
• Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1). Bioorganic and Medicinal Chemistry Journal 2013. PMID 24262887
• Differential response of orthologous L,L-diaminopimelate aminotransferases (DapL) to enzyme inhibitory antibiotic lead compounds. Bioorganic and Medicinal Chemistry Journal 2013. PMID 24268540
• Cell-based antiviral screening against coronaviruses: Developing virus-specific and broad-spectrum inhibitors. Antiviral Research 2013. PMID 24269477
• Synthesis of Complex and Diverse Compounds through Ring Distortion of Abietic Acid. Angewandte Chemie International Edition 2013. PMID 24273016
• Fragment based discovery of arginine isosteres through REPLACE: Towards non-ATP competitive CDK inhibitors. Bioorganic and Medicinal Chemistry Journal 2013. PMID 24286762
• PITPs as targets for selectively interfering with phosphoinositide signaling in cells. Nature Chemical Biology 2013. PMID 24292071
• An NF-kB-Based High-Throughput Screen Identifies Piericidins as Inhibitors of the Yersinia pseudotuberculosis Type III Secretion System . Antimicrobial Agents and Chemotherapy 2013. PMID 24295981
• Molecular modeling, quantum polarized ligand docking and structure-based 3D-QSAR analysis of the imidazole series as dual AT(1) and ET(A) receptor antagonists.. Acta Pharmacologica Sinica 2013. PMID 24304920
• Calcium Signaling via Orai1 Is Essential for Induction of the Nuclear Orphan Receptor Pathway To Drive Th17 Differentiation . Journal of Immunology 2013. PMID 24307733
• The stability of secreted, acid-labile H77/JFH-1 hepatitis C virus (HCV) particles is altered by patient isolate genotype 1a p7 sequences.. Virology 2013. PMID 24314642
• DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities. Molecular Cell 2013. PMID 24316220
• Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.. Nature Cell Biology 2013. PMID 24316671
• Suppression of type 1 pilus assembly in uropathogenic Escherichia coli by chemical inhibition of subunit polymerization. Journal of Antimicrobial Chemotherapy 2013. PMID 24324225
• The discovery of potent, orally bioavailable pyrazolo and triazolopyrimidine CXCR2 receptor antagonists. Bioorganic and Medicinal Chemistry Letters 2013. PMID 24332493
• Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings. Bioorganic and Medicinal Chemistry Journal 2013. PMID 24332657
• A Screen for and Validation of Prodrug Antimicrobials. Antimicrobial Agents and Chemotherapy 2013. PMID 24342644
• Metal-Induced Isomerization Yields an Intracellular Chelator that Disrupts Bacterial Iron Homeostasis. Chemistry and Biology 2013. PMID 24361049
• A secreted peptide acts on BIN2-mediated phosphorylation of ARFs to potentiate auxin response during lateral root development. Nature Cell Biology 2013. PMID 24362628
• Identification of Small-Molecule Frequent Hitters from AlphaScreen High-Throughput Screens. Journal of Biomolecular Screening 2013. PMID 24371213
• Computational Methods in Drug Discovery. Pharmacological Reviews 2013. PMID 24381236
• Saturation transfer difference NMR for fragment screening. Current Protocols in Chemical Biology 2013. PMID 24391096
• Identification of shikimate kinase inhibitors among anti- Mycobacterium tuberculosis compounds by LC-MS. Tuberculosis 2013. PMID 24429106
• Synthetic Molecules: Helping to Unravel Plant Signal Transduction. Other 2013. PMID 24432124
• Bayesian Models for Screening and TB Mobile for Target Inference with Mycobacterium tuberculosis. Tuberculosis 2013. PMID 24440548
• Design, development, and validation of a high-throughput drug-screening assay for targeting of human leukemia. Cancer 2013. PMID 24496871
• Chapter Eight – Targeting the Dbl and Dock-Family RhoGEFs: A Yeast-Based Assay to Identify Cell-Active Inhibitors of Rho-Controlled Pathways. The Enzymes 2013. PMID 25033805
• MMsDusty: an Alternative InChI-Based Tool to Minimize Chemical Redundancy. Molecular Informatics 2013. PMID 27480060
• Exploring the Molecular Basis of Qobc1 Complex Inhibitors Activity to Find Novel Antimalarials Hits. Molecular Informatics 2013. PMID 27481771
• Use of Chemical Biology to Understand Auxin Metabolism, Signaling, and Polar Transport. Book Chapter 2013. PMID N/A
• In Vitro Propagation. Book Chapter 2013. PMID N/A
• The Use of Small Molecules to Dissect Cell Wall Biosynthesis and Manipulate the Cortical Cytoskeleton. Book Chapter 2013. PMID N/A
• Chemical Genetic Approaches on ABA Signal Transduction. Book Chapter 2013. PMID N/A
• Front Matter. Book Chapter 2013. PMID N/A
• Chemical Genetics as a Tool to Study Ethylene Biology in Plants. Book Chapter 2013. PMID N/A
• The Use of Chemical Biology to Study Plant Cellular Processes. Book Chapter 2013. PMID N/A
• Compound Collections. Book Chapter 2013. PMID N/A
• Effect of electronic spatial extents (ESE) of ions on overpotential of lithium ion capacitors. Electrochimica Acta 2013. PMID N/A
• Antibiotics Targeting Bacterial RNA Polymerase. Book Chapter 2013. PMID N/A
• Syntheses and flame retarding properties of DOPO polymers, melamine polymers, and DOPO-melamine copolymers. Polymers for Advanced Technologies 2013. PMID N/A
• Heterogeneous oxidation of folpet and dimethomorph by OH radicals: A kinetic and mechanistic study. Atmospheric Environment 2013. PMID N/A
• The novel peroxisome proliferator-activated receptor gamma (PPARg) agonists CB11 and CB11d, induced apoptosis through DNA damage by reactive oxygen species (ROS) in a human non-small cell lung cancer (NSCLC) cell line H460. European Journal of Cancer 2013. PMID N/A
• Kinetics and mechanism of 5-hydroxymethylfurfural oxidation and their implications for catalyst development. Journal of Molecular Catalysis - All 2013. PMID N/A
• Transient receptor potential ankyrin 1 (TRPA1) ion channel in the pathophysiology of peripheral diabetic neuropathy. Scandinavian Journal of Pain 2013. PMID N/A
• Discovery and Mechanism of Type III Secretion System Inhibitors. Israel Journal of Chemistry 2013. PMID N/A
• Pronociceptive effects of a TRPA1 channel agonist methylglyoxal in healthy control and diabetic animals. Scandinavian Journal of Pain 2013. PMID N/A
• Chemoinformatics applications of cluster analysis. WIREs Computational Molecular Science 2013. PMID N/A
• Tetraamido-oxacalix[4]arene Derivatives: Synthesis, Structures and Supramolecular Assemblie. Chinese Journal of Chemistry 2013. PMID N/A
• Xylyl derived oxacalixcrowns: Synthesis and crystal structure. Chinese Chemical Letters 2013. PMID N/A
• Organic nano-particle capping with polymeric surfactant dispersed by supercritical carbon dioxide in the binary solvent. Chemical Engineering and Processsing: Process Intensification 2013. PMID N/A
• m-Terphenyl-3,3\"-dioxo-derived oxacalixaromatics: synthesis, structure, and solvent encapsulation in the solid state. Tetrahedron 2013. PMID N/A
• Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties.. Book Chapter 2013. PMID N/A
• Hierarchical Self-Assembly of Amphiphilic Homopolymer into Unique Superstructures. ACS Macro Letters 2013. PMID
• Scientific Programme – Proffered Papers . European Journal of Cancer 2013. PMID
• Rapid in silico selection of an MCHR1 antagonists’ focused library from multi-million compounds’ repositories: biological evaluation. Medicinal Chemistry Research 2013. PMID
• Rapid in silico selection of an MCHR1 antagonists’ focused library from multi-million compounds’ repositories: biological evaluation.. Medicinal Chemistry Research 2013. PMID
• Pathways to Thyroid Stimulation: Identification of New Potent and Selective Small Molecular Agonists to the TSH Receptor. Abstract 2013. PMID
• Increasing mitochondrial respiratory capacity is protective in models of photoreceptor cell degeneration. Meeting Abstract 2013. PMID
• Chemical Screens in Zebrafish Identify Novel Inhibitors of Retinal Neovascularisation in Mouse. Meeting Abstract 2013. PMID
• Graphical Abstracts/Chin Chem Lett 24 (2013) iii-viii. Chinese Chemical Letters 2013. PMID
• Molecular modeling of the Candida albicans Vps4 and a virtual screening study for novel inhibitors. Medicinal Chemistry Research 2013. PMID