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2015-2016 Research Articles Citing ChemBridge

Below is a partial list of articles citing the use of ChemBridge libraries and compounds. The list is updated as additional articles are identified. The PMID value can be used to link to the record at the PubMed website.

• TRPs and Pain. Other 2016. PMID 26374740
• Chlamydia trachomatis utilizes the mammalian CLA1 lipid transporter to acquire host phosphatidylcholine essential for growth. Cellular Microbiology 2016. PMID 26381674
• Small Molecules That Protect Mitochondrial Function From Metabolic Stress Decelerate Loss of Photoreceptor Cells in Murine Retinal Degeneration Models. Other 2016. PMID 26427445
• Application of Eukaryotic Elongation Factor-2 Kinase (eEF-2K) for Cancer Therapy: Expression, Purification, and High-Throughput Inhibitor Screening. Other 2016. PMID 26501899
• Recombinant Kinase Production and Fragment Screening by NMR Spectroscopy. Other 2016. PMID 26501900
• Identification and Characterization of Novel Small Molecule Inhibitors of the Acetyltransferase Activity of Escherichia Coli N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Other 2016. PMID 26563552
• Specific Inhibitors of HIV Capsid Assembly Binding to the C‑Terminal Domain of the Capsid Protein: Evaluation of 2‑Arylquinazolines as Potential Antiviral Compounds. Journal of Medicinal Chemistry 2016. PMID 26685880
• Structure-Based Discovery of Novel and Selective 5-Hydroxytryptamine 2B Receptor Antagonists for the Treatment of Irritable Bowel Syndrome.. Journal of Medicinal Chemistry 2016. PMID 26700945
• Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation.. Journal of Medicinal Chemistry 2016. PMID 26731490
• Virtual Screening and Experimental Validation Identify Novel Inhibitors of the Plasmodium falciparum Atg8–Atg3 Protein–Protein Interaction. ChemMedChem 2016. PMID 26748931
• Ensemble-Based Virtual Screening Led to the Discovery of New Classes of Potent Tyrosinase Inhibitors.. Journal of Chemical Information and Modeling 2016. PMID 26750991
• Aryl Hydrocarbon Receptor-Dependent Pathways in Immune Regulation. American Journal of Transplantation 2016. PMID 26751261
• Neuroplasticity of Ascending and Descending Pathways After Somatosensory System Injury: Reviewing Knowledge to Identify Neuropathic Pain Therapeutic Targets. Other 2016. PMID 26754470
• The 340-cavity in neuraminidase provides new opportunities for influenza drug development: A molecular dynamics simulation study. Biochemical and Biophysical Research Communications 2016. PMID 26768362
• Exploration of Novel Inhibitors for Bruton's Tyrosine Kinase by 3D QSAR Modeling and Molecular Dynamics Simulation. PLoS ONE 2016. PMID 26784025
• A Covalent Cysteine-Targeting Kinase Inhibitor of Ire1 Permits Allosteric Control of Endoribonuclease Activity. ChemBioChem 2016. PMID 26792008
• Transient receptor potential cation channel, subfamily V, member 4 and airway sensory afferent activation: Role of adenosine triphosphate. The Journal of Allergy and Clinical Immunology 2016. PMID 26792207
• Identification of initial leads directed at the calmodulin-binding region on the Src-SH2 domain that exhibit anti-proliferation activity against pancreatic cancer. Bioorganic and Medicinal Chemistry Letters 2016. PMID 26803204
• Computationally Guided Identification of Novel Mycobacterium tuberculosis GlmU Inhibitory Leads, Their Optimization, and in Vitro Validation.. ACS Combinatorial Science 2016. PMID 26812086
• Investigation on the isoform selectivity of novel kinesin-like protein 1 (KIF11) inhibitor using chemical feature based pharmacophore, molecular docking, and quantum mechanical studies. Computational Biology and Chemistry 2016. PMID 26815769
• A novel compact mass detection platform for the open access (OA) environment in drug discovery and early development. Journal of Pharmaceutical and Biomedical Analysis 2016. PMID 26821286
• Fragment-Based Protein–Protein Interaction Antagonists of a Viral Dimeric Protease. ChemMedChem 2016. PMID 26822284
• Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-Cells.. ACS Chemical Biology 2016. PMID 26828310
• Antioxidant Potential and Ability of Phloroglucinol to Decrease Formation of Advanced Glycation End Products Increase Efficacy of Sildenafil in Diabetes-Induced Sexual Dysfunction of Rats. Sex Medicine 2016. PMID 26831914
• Quadruplex Nucleic Acids as Novel Therapeutic Targets.. Journal of Medicinal Chemistry 2016. PMID 26840940
• Phenotype-based Discovery of 2-[(E)-2-(Quinolin-2-yl)vinyl]phenol as a Novel Regulator of Ocular Angiogenesis. Journal of Biological Chemistry 2016. PMID 26846851
• Uptake and levels of the antibiotic berberine in individual dormant and germinating Clostridium difficile and Bacillus cereus spores as measured by laser tweezers Raman spectroscopy. Journal of Antimicrobial Chemotherapy 2016. PMID 26861569
• Investigation of vital pathogenic target orotate phosphoribosyltransferases (OPRTase) from Thermus thermophilus HB8: Phylogenetic and molecular modeling approach. Gene 2016. PMID 26861612
• Discovery of Novel Allosteric Eg5 Inhibitors Through Structure-Based Virtual Screening. Chemical Biology and Drug Design 2016. PMID 26864917
• Nuclear envelope expansion is crucial for proper chromosomal segregation during a closed mitosis. Journal of Cell Science 2016. PMID 26869222
• The Small Molecule '1-(4-biphenylylcarbonyl)-4-(5-bromo-2-methoxybenzyl) Piperazine Oxalate' and Its Derivatives Regulate Global Protein Synthesis by Inactivating Eukaryotic Translation Initiation Factor 2-alpha. Other 2016. PMID 26873011
• Targeting BRCA1- And BRCA2-deficient Cells With RAD52 Small Molecule Inhibitors. Nucleic Acids Research 2016. PMID 26873923
• Screening of Antitubercular Compound Library Identifies Novel Shikimate Kinase Inhibitors of Mycobacterium Tuberculosis. Other 2016. PMID 26887318
• Identification of a Small-Molecule Ligand of the Epigenetic Reader Protein Spindlin1 via a Versatile Screening Platform. Nucleic Acids Research 2016. PMID 26893353
• New p32/gC1qR Ligands for Targeted Tumor Drug Delivery. ChemBioChem 2016. PMID 26895508
• Identification of Adjuvantic Activity of Amphotericin B in a Novel, Multiplexed, Poly-TLR/NLR High-Throughput Screen. PLoS ONE 2016. PMID 26919709
• Structural elements that govern Sec14-like PITP sensitivities to potent small molecule inhibitors. Journal of Lipid Research 2016. PMID 26921357
• Characterization of Cardiac Glycoside Natural Products as Potent Inhibitors of DNA Double-Strand Break Repair by a Whole-Cell Double Immunofluorescence Assay.. Journal of the American Chemical Society 2016. PMID 26927829
• Small Molecule Inhibition of Ligand-Stimulated RAGE-DIAPH1 Signal Transduction. Scientific Reports 2016. PMID 26936329
• A Novel Small-Molecule Inhibitor of Influenza A Virus Acts by Suppressing PA Endonuclease Activity of the Viral Polymerase. Scientific Reports 2016. PMID 26956222
• Development of a Microemulsion Formulation for Antimicrobial SecA Inhibitors. PLoS ONE 2016. PMID 26963811
• Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.. Journal of Natural Products 2016. PMID 26967980
• Screening for Non-Pore-Binding Modulators of EAG K+ Channels. Journal of Biomolecular Screening 2016. PMID 26975997
• In Vitro Screening of the Open-Source Medicines for Malaria Venture Malaria Box Reveals Novel Compounds with Profound Activities against Theileria annulata Schizonts. Antimicrobial Agents and Chemotherapy 2016. PMID 26976863
• Transcriptional response networks for elucidating mechanisms of action of multitargeted agents. Drug Discovery Today 2016. PMID 26979547
• The paracaspase MALT1 cleaves the LUBAC subunit HOIL1 during antigen receptor signaling. Journal of Cell Science 2016. PMID 27006117
• Discovery, Optimization, and Biological Evaluation of Sulfonamidoacetamides as an Inducer of Axon Regeneration.. Journal of Medicinal Chemistry 2016. PMID 27007292
• Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain.. Journal of Medicinal Chemistry 2016. PMID 27015369
• Identification of N-phenyl-2-(N-phenylphenylsulfonamido) acetamides as new RORg inverse agonists: Virtual screening, structure-based optimization, and biological evaluation. European Journal of Medicinal Chemistry 2016. PMID 27043267
• Development of an Enhanced Phenotypic Screen of Cytotoxic T-Lymphocyte Lytic Granule Exocytosis Suitable for Use With Synthetic Compound and Natural Product Collections. Journal of Biomolecular Screening 2016. PMID 27048485
• Substrate and Inhibitor Specificity of the Plasmodium berghei Equilibrative Nucleoside Transporter Type 1s. Molecular Pharmacology 2016. PMID 27048953
• Novel sesquiterpene lactone analogues as potent anti-breast cancer agents. Molecular Oncology 2016. PMID 27055598
• Zebrafish embryo toxicity of anaerobic biotransformation products from the insensitive munitions compound 2,4-dinitroanisole.. Environmental Toxicology and Chemistry 2016. PMID 27058972
• Small molecule activation of apurinic/apyrimidinic endonuclease 1reduces DNA damage induced by cisplatin in cultured sensory neurons. DNA Repair 2016. PMID 27078577
• A review on ROCK-II inhibitors: From molecular modelling to synthesis. Bioorganic and Medicinal Chemistry Letters 2016. PMID 27080184
• Microbial toxicity and characterization of DNAN (bio)transformation product mixtures. Chemosphere 2016. PMID 27085064
• Delineation of the functional properties and the mechanism of action of TMPPAA, an allosteric agonist and positive allosteric modulator of 5-HT3 receptors. Biochemical Pharmacology 2016. PMID 27086281
• A1/A2-Diamino-Substituted Pillar[5]arene-Based Acid-Base-Responsive Host-Guest System.. Journal of Organic Chemistry 2016. PMID 27088317
• Novel cell-free high-throughput screening method for pharmacological tools targeting K+ channels. Proceedings of the National Academy of Sciences 2016. PMID 27091997
• Identifying GSK-3β kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays. European Journal of Pharmaceutical Sciences 2016. PMID 27094783
• Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301. PLoS ONE 2016. PMID 27097159
• Novel 1H-Pyrrolo[3,2-c]quinoline Based 5-HT6 Receptor Antagonists with Potential Application for the Treatment of Cognitive Disorders Associated with Alzheimer's Disease.. ACS Chemical Neuroscience 2016. PMID 27100049
• Constructing and Validating High-Performance MIEC-SVM Models in Virtual Screening for Kinases: A Better Way for Actives Discovery. Scientific Reports 2016. PMID 27102549
• Design, discovery, modelling, synthesis, and biological evaluation of novel and small, low toxicity s-triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorganic and Medicinal Chemistry Journal 2016. PMID 27108399
• Identification of MAC1: A Small Molecule That Rescues Spindle Bipolarity in Monastrol-Treated Cells.. ACS Chemical Biology 2016. PMID 27121275
• A High-Throughput Cell-Based Screen Identified a 2-[(E)-2-Phenylvinyl]-8-Quinolinol Core Structure That Activates p53. PLoS ONE 2016. PMID 27124407
• Design Principles for Fragment Libraries: Maximizing the Value of Learnings from Pharma Fragment-Based Drug Discovery (FBDD) Programs for Use in Academia.. Journal of Medicinal Chemistry 2016. PMID 27124799
• (E)-3-Heteroarylidenechroman-4-ones as potent and selective monoamine oxidase-B inhibitors. European Journal of Medicinal Chemistry 2016. PMID 27135371
• Discovery of a novel NEDD8 Activating Enzyme Inhibitor with Piperidin-4-amine Scaffold by Structure-Based Virtual Screening. ACS Chemical Biology 2016. PMID 27135934
• The Cell Surface Receptor CD44: NMR-Based Characterization of Putative Ligands. ChemMedChem 2016. PMID 27144715
• Lassa Virus Cell Entry via Dystroglycan Involves an Unusual Pathway of Macropinocytosis. Journal of Virology 2016. PMID 27147735
• Benzothiazole Derivative as a Novel Mycobacterium tuberculosis Shikimate Kinase Inhibitor: Identification and Elucidation of Its Allosteric Mode of Inhibition.. Journal of Chemical Information and Modeling 2016. PMID 27149193
• Small Molecules Antagonise the MIA-Fibronectin Interaction in Malignant Melanoma. Scientific Reports 2016. PMID 27151361
• Global Survey of Cell Death Mechanisms Reveals Metabolic Regulation of Ferroptosis. Nature Chemical Biology 2016. PMID 27159577
• Identifying Novel Cancer Therapies Using Chemical Genetics and Zebrafish. Other 2016. PMID 27165351
• The Pentose Phosphate Pathway in Parasitic Trypanosomatids. Trends in Parisitology 2016. PMID 27174163
• Scaffold Diversity Synthesis and Its Application in Probe and Drug Discovery. Angewandte Chemie International Edition 2016. PMID 27187638
• The Small Molecule Hyperphyllin Enhances Leaf Formation Rate and Mimics Shoot Meristem Integrity Defects Associated with AMP1 Deficiency. Plant Physiology 2016. PMID 27208298
• Influence of metabolism on endocrine activities of bisphenol S.. Chemosphere 2016. PMID 27213244
• Active Site Fingerprinting and Pharmacophore Screening Strategies for the Identification of Dual Inhibitors of Protein Kinase C (ΡΚCBeta) and Poly (ADP-ribose) polymerase-1 (PARP-1). Molecular Diversity 2016. PMID 27216445
• Small Molecule DFPM Derivative-Activated Plant Resistance Protein Signaling in Roots Is Unaffected by EDS1 Subcellular Targeting Signal and Chemical Genetic Isolation of victr R-Protein Mutants. PLoS ONE 2016. PMID 27219122
• Zebrafish Behavioral Profiling Identifies Multitarget Antipsychotic-Like Compounds. Nature Chemical Biology 2016. PMID 27239787
• Sigma-1 receptor ligands control a switch between passive and active threat responses.. Nature Chemical Biology 2016. PMID 27239788
• Cellular Assays with a Molecular Endpoint Measured by SAMDI Mass Spectrometry.. Small 2016. PMID 27240220
• Transcriptional Inhibitors Identified in a 160,000-Compound Small-Molecule DUX4 Viability Screen. Journal of Biomolecular Screening 2016. PMID 27245141
• Small Molecules Revealed in a Screen Targeting Epithelial Scattering Are Inhibitors of Microtubule Polymerization. Journal of Biomolecular Screening 2016. PMID 27245142
• Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake. Science Signaling 2016. PMID 27245612
• QSAR-Driven Discovery of Novel Chemical Scaffolds Active against Schistosoma mansoni.. Journal of Chemical Information and Modeling 2016. PMID 27253773
• A Shape-Persistent Cryptand for Capturing Polycyclic Aromatic Hydrocarbons.. Journal of Organic Chemistry 2016. PMID 27258531
• ARF6 Is an Actionable Node that Orchestrates Oncogenic GNAQ Signaling in Uveal Melanoma. Cancer Cell 2016. PMID 27265506
• Thiazolo[3,2-a]benzimidazol-3(2H)-one derivatives: Structure– activity relationships of selective nucleotide pyrophosphatase/ phosphodiesterase1 (NPP1) inhibitors. Bioorganic and Medicinal Chemistry Journal 2016. PMID 27265686
• Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification. Nature Communications 2016. PMID 27271794
• A novel small-molecule compound disrupts influenza A virus PB2 cap-binding and inhibits viral replication. Journal of Antimicrobial Chemotherapy 2016. PMID 27272726
• Predictive Modeling Targets Thymidylate Synthase ThyX in Mycobacterium Tuberculosis. Scientific Reports 2016. PMID 27283217
• Discovery of 3-benzyl-1,3-benzoxazine-2,4-dione analogues as allosteric mitogen-activated kinase kinase (MEK) inhibitors and anti-enterovirus 71 (EV71) agents. Bioorganic and Medicinal Chemistry Journal 2016. PMID 27288186
• Anti-inflammatory effects of novel barbituric acid derivatives in T lymphocytes. International Immunopharmacology 2016. PMID 27302770
• Acridine Derivatives as Inhibitors of the IRE1a–XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma. Molecular Cancer Therapeutics 2016. PMID 27307600
• Understanding biophysical behaviours of microfluidic-synthesized nanoparticles at nano-biointerface.. Colloids and Surfaces - All Sections 2016. PMID 27311130
• Enriching screening libraries with bioactive fragment space. Bioorganic and Medicinal Chemistry Letters 2016. PMID 27311891
• Inhibition of Plasmodium falciparum Hsp90 Contributes to the Antimalarial Activities of Aminoalcohol-carbazoles.. Journal of Medicinal Chemistry 2016. PMID 27312008
• High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes.. ACS Combinatorial Science 2016. PMID 27314875
• Optimized Reaction Conditions for Amide Bond Formation in DNA-Encoded Combinatorial Libraries.. ACS Combinatorial Science 2016. PMID 27314981
• CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements. Oncotarget 2016. PMID 27317766
• Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice. Journal of Pharmacology and Experimental Therapeutics 2016. PMID 27317802
• Synthesis and biological evaluation of indole-2-carboxamides bearing photoactivatable functionalities as novel allosteric modulators for the cannabinoid CB1 receptor. European Journal of Medicinal Chemistry 2016. PMID 27318976
• Direct targeting of β-catenin by a small molecule stimulates proteasomal degradation and suppresses oncogenic Wnt/β-catenin signaling. Cell Reports 2016. PMID 27320923
• A Multimodal Data Analysis Approach for Targeted Drug Discovery Involving Topological Data Analysis (TDA). Select Journal Title 2016. PMID 27325272
• ICAM-1 Binding Rhinoviruses A89 and B14 Uncoat in Different Endosomal Compartments. Journal of Virology 2016. PMID 27334586
• Function-specific Virtual Screening for GPCR Ligands Using a Combined Scoring Method. Scientific Reports 2016. PMID 27339552
• Identification of Novel Inhibitors of the Type I Interferon Induction Pathway Using Cell-Based High-Throughput Screening. Journal of Biomolecular Screening 2016. PMID 27358388
• A novel compound 2-(4-{2-[(phenylthio)acetyl]carbonohydrazonoyl}phenoxy)acetamide downregulates TSLP through blocking of caspase-1/NF-κB pathways. International Immunopharmacology 2016. PMID 27376852
• Tetranitro-oxacalix[4]crown-Based Host-Guest Recognition Motif and a Related [2]Rotaxane-Based Molecular Switch.. Journal of Organic Chemistry 2016. PMID 27384815
• Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening.. Journal of Medicinal Chemistry 2016. PMID 27391133
• Discovery of New Anti-Schistosomal Hits by Integration of QSAR-Based Virtual Screening and High Content Screening.. Journal of Medicinal Chemistry 2016. PMID 27396732
• Rosette-Disrupting Effect of an Anti-Plasmodial Compound for the Potential Treatment of Plasmodium Falciparum Malaria Complications. Scientific Reports 2016. PMID 27403804
• Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening.. Journal of Medicinal Chemistry 2016. PMID 27405689
• Promising Tools in Prostate Cancer Research: Selective Non-Steroidal Cytochrome P450 17A1 Inhibitors. Scientific Reports 2016. PMID 27406023
• Novel Small Molecules Potentiate Premature Termination Codon Readthrough by Aminoglycosides. Nucleic Acids Research 2016. PMID 27407112
• Progress in the Development of Lysine Methyltransferase SETD8 Inhibitors. ChemMedChem 2016. PMID 27411844
• Protein-observed (19)F-NMR for Fragment Screening, Affinity Quantification and Druggability Assessment. Nature Protocols 2016. PMID 27414758
• Discovery of novel TAOK2 inhibitor scaffolds from high-throughput screening. Bioorganic and Medicinal Chemistry Letters 2016. PMID 27426302
• SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington’s Disease Models. Cell 2016. PMID 27427231
• SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.. Cell Chemical Biology 2016. PMID 27427231
• Small-molecule Antagonists of Germination of the Parasitic Plant Striga Hermonthica. Nature Chemical Biology 2016. PMID 27428512
• Substrate independent ATPase activity may complicate high throughput screening. Analytical Biochemistry 2016. PMID 27430931
• New anti-cancer chemicals Ertredin and its derivatives, regulate oxidative phosphorylation and glycolysis and suppress sphere formation in vitro and tumor growth in EGFRvIII-transformed cells.. BMC Cancer 2016. PMID 27431653
• Glycolytic Regulation of Cell Rearrangement in Angiogenesis. Nature Communications 2016. PMID 27436424
• Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1.. ACS Medicinal Chemistry Letters 2016. PMID 27437077
• Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction.. Bioorganic and Medicinal Chemistry Journal 2016. PMID 27448776
• Discovery and characterization of novel small-molecule CXCR4 receptor agonists and antagonists. Scientific Reports 2016. PMID 27456816
• Utilizing native fluorescence imaging, modeling and simulation to examine pharmacokinetics and therapeutic regimen of a novel anticancer prodrug.. BMC Cancer 2016. PMID 27457630
• IRES Inhibition Induces Terminal Differentiation and Synchronized Death in Triple-Negative Breast Cancer and Glioblastoma Cells. Other 2016. PMID 27460074
• Chemical Screening in Zebrafish. Other 2016. PMID 27464797
• Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development.. Developmental Biology 2016. PMID 27474396
• Dual pharmacological inhibition of glutathione and thioredoxin systems synergizes to kill colorectal carcinoma stem cells. Cancer Medicine 2016. PMID 27485632
• Driving Structure-Based Drug Discovery through Cosolvent Molecular Dynamics.. Journal of Medicinal Chemistry 2016. PMID 27486927
• Targeting CYP51 for drug design by the contributions of molecular modeling. Fundamental and Clinical Pharmacology 2016. PMID 27487199
• Hydration Free Energy as a Molecular Descriptor in Drug Design: A Feasibility Study. Molecular Informatics 2016. PMID 27492087
• Sortilin facilitates VLDL-B100 secretion by insulin sensitive McArdle RH7777 cells. Biochemical and Biophysical Research Communications 2016. PMID 27495870
• Protein kinase C-d inhibitor, Rottlerin inhibits growth and survival of mycobacteria exclusively through Shikimate kinase. Biochemical and Biophysical Research Communications 2016. PMID 27498028
• Ca-asp bound X-ray structure and inhibition of Bacillus anthracis dihydroorotase (DHOase). Bioorganic and Medicinal Chemistry Journal 2016. PMID 27499369
• A novel small molecule that disrupts a key event during the oocyte-to-embryo transition in C. elegans. Developmental Cell 2016. PMID 27510972
• A small molecule-based strategy for endothelial differentiation and three-dimensional morphogenesis from human embryonic stem cells. Heliyon 2016. PMID 27512727
• Discovery and Evaluation of PRL Trimer Disruptors for Novel Anticancer Agents. Other 2016. PMID 27514804
• Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES).. Journal of Medicinal Chemistry 2016. PMID 27529560
• Novel bis-arylalkylamines as myeloperoxidase inhibitors: Design, synthesis, and structure-activity relationship study.. European Journal of Medicinal Chemistry 2016. PMID 27537923
• High-throughput screening for the identification of small-molecule inhibitors of the flaviviral protease.. Antiviral Research 2016. PMID 27539384
• Inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity suppresses microglia-mediated inflammatory responses. Clinical and Experimental Pharmacology and Physiology 2016. PMID 27543936
• A Novel Multi-step Virtual Screening for the Identification of Human and Mouse mPGES-1 Inhibitors. Molecular Informatics 2016. PMID 27546040
• Pharmacophore Model To Discover OX1 and OX2 Orexin Receptor Ligands.. Journal of Medicinal Chemistry 2016. PMID 27546834
• FABP1: A Novel Hepatic Endocannabinoid and Cannabinoid Binding Protein.. Biochemistry 2016. PMID 27552286
• Selective killing of cancer cells by small molecules targeting heat shock stress response. Biochemical and Biophysical Research Communications 2016. PMID 27553278
• Tetrahydrocarbazoles decrease elevated SOCE in medium spiny neurons from transgenic YAC128 mice, a model of Huntington's disease. Biochemical and Biophysical Research Communications 2016. PMID 27553284
• Cell Painting, a High-Content Image-Based Assay for Morphological Profiling Using Multiplexed Fluorescent Dyes. Nature Protocols 2016. PMID 27560178
• The Characterization of an Intestine-Like Genomic Signature Maintained During Barrett's-associated Adenocarcinogenesis Reveals an NR5A2-mediated Promotion of Cancer Cell Survival. Scientific Reports 2016. PMID 27586588
• Thrombospondin 1 Protects Pancreatic Beta-Cells From Lipotoxicity via the PERK-NRF2 Pathway. Cell Death and Differentiation 2016. PMID 27588705
• Discovery of Novel Antischistosomal Agents by Molecular Modeling Approaches. Trends in Parisitology 2016. PMID 27593339
• Partially Saturated Bicyclic Heteroaromatics as an sp3-Enriched Fragment Collection. Angewandte Chemie International Edition 2016. PMID 27596095
• Crystal Structures of Peptide Deformylase from Rice Pathogen Xanthomonas oryzae pv. oryzae in Complex with Substrate Peptides, Actinonin, and Fragment Chemical Compounds.. Journal of Agricultural and Food Chemistry 2016. PMID 27616570
• NMR Study of Met-1 Human Angiogenin: (1)H, (13)C, (15)N Backbone and Side-Chain Resonance Assignment. Other 2016. PMID 27624767
• A Small-Molecule Screening Platform for the Discovery of Inhibitors of Undecaprenyl Diphosphate Synthase.. ACS Infectious Diseases 2016. PMID 27626101
• Diphenylether-Modified 1,2-Diamines with Improved Drug Properties for Development against Mycobacterium tuberculosis.. ACS Infectious Diseases 2016. PMID 27626102
• Identification of a New Class of Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitors Followed by a Structure-Activity Relationship Study.. Journal of Medicinal Chemistry 2016. PMID 27626828
• In Search of Novel Ligands Using a Structure-Based Approach: A Case Study on the Adenosine A 2A Receptor. Select Journal Title 2016. PMID 27629350
• Identification and Structure–Activity Relationship Studies of Small-Molecule Inhibitors of the Methyllysine Reader Protein Spindlin1. ChemMedChem 2016. PMID 27634332
• Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell 2016. PMID 27641501
• A Target-Based Whole Cell Screen Approach To Identify Potential Inhibitors of Mycobacterium tuberculosis Signal Peptidase.. ACS Infectious Diseases 2016. PMID 27642770
• Access to a Structurally Complex Compound Collection via Ring Distortion of the Alkaloid Sinomenine.. Organic Letters 2016. PMID 27650404
• Fragment-based Discovery of a New Family of Non-Peptidic Small-Molecule Cyclophilin Inhibitors With Potent Antiviral Activities. Nature Communications 2016. PMID 27652979
• Inhibition of soluble guanylyl cyclase by small molecules targeting the catalytic domain. FEBS Letters 2016. PMID 27654641
• Phosphatidylinositol (3,4,5)-trisphosphate binds to sortilin and competes with neurotensin: Implications for very low density lipoprotein binding. Biochemical and Biophysical Research Communications 2016. PMID 27666481
• Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors.. Journal of Medicinal Chemistry 2016. PMID 27673482
• Mechanical antihypersensitivity effect induced by repeated spinal administrations of a TRPA1 antagonist or a gap junction decoupler in peripheral neuropathy. Pharmacoloy, Biochemistry and Behavior 2016. PMID 27677209
• 3D pharmacophore-based virtual screening, docking and density functional theory approach towards the discovery of novel human epidermal growth factor receptor-2 (HER2) inhibitors. Journal of Theoretical Biology 2016. PMID 27693363
• Identification of non-resistant ROS-1 inhibitors using structure basedpharmacophore analysis. Journal of Molecular Graphics and Modelling 2016. PMID 27693947
• Structural Basis for PPAR Partial or Full Activation Revealed by a Novel Ligand Binding Mode. Scientific Reports 2016. PMID 27708429
• Inhibitors of retrograde trafficking active against ricin and Shiga toxins also protect cells from several viruses, Leishmania and Chlamydiales. Chemico-Biological Interactions 2016. PMID 27712998
• A High-Throughput Small Molecule Screen for C. elegans Linker Cell Death Inhibitors. PLoS ONE 2016. PMID 27716809
• Preclinical Validation of the Small Molecule Drug Quininib as a Novel Therapeutic for Colorectal Cancer. Scientific Reports 2016. PMID 27739445
• Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic Activity. PLoS Neglected Tropical Diseases 2016. PMID 27755544
• Benzimidazole-Based FabI Inhibitors: A Promising Novel Scaffold for Anti-staphylococcal Drug. ACS Infectious Diseases 2016. PMID 27756129
• Formin DAAM1 Organizes Actin Filaments in the Cytoplasmic Nodal Actin Network. PLoS ONE 2016. PMID 27760153
• Targeting Epithelial-Mesenchymal Transition for Identification of Inhibitors for Pancreatic Cancer Cell Invasion and Tumor Spheres Formation. PLoS ONE 2016. PMID 27764163
• 1,2,4-Triazolidine-3-thiones Have Specific Activity against Acinetobacter baumannii among Common Nosocomial Pathogens.. ACS Infectious Diseases 2016. PMID 27764938
• Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis. PLoS ONE 2016. PMID 27768711
• Activation of HIV-1 expression in latently infected CD4+ T cells by the small molecule PKC412.. Virology 2016. PMID 27769267
• Novel non-b-lactam inhibitor of b-lactamase TEM-171 based on acylated phenoxyaniline. Biochimie 2016. PMID 27771370
• Auxotrophy-based High Throughput Screening Assay for the Identification of Bacillus Subtilis Stringent Response Inhibitors. Scientific Reports 2016. PMID 27775002
• Recent Developments Using Small Molecules to Target RAD51: How to Best Modulate RAD51 for Anticancer Therapy?. ChemMedChem 2016. PMID 27781374
• Lead discovery for mammalian elongation of long chain fatty acids family 6 using a combination of high-throughput fluorescent-based assay and RapidFire mass spectrometry assay. Biochemical and Biophysical Research Communications 2016. PMID 27793673
• Fragment library design, synthesis and expansion: nurturing a synthesis and training platform. Drug Discovery Today 2016. PMID 27793744
• Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer. Science Translational Medicine 2016. PMID 27798265
• Identification of Compounds that Selectively Stabilize Specific G-Quadruplex Structures by Using a Thioflavin T-Displacement Assay as a Tool. Chemistry - A European Journal 2016. PMID 27862378
• Proceedings of the World Molecular Imaging Congress 2016, New York, New York, September 7-10, 2016: General Abstracts. Other 2016. PMID 27873044
• In Silico Exploration for Novel Type-I Inhibitors of Tie-2/TEK: The Performance of Different Selection Strategy in Selecting Virtual Screening Candidates. Scientific Reports 2016. PMID 27876862
• Selective Antagonism of TRPA1 Produces Limited Efficacy in Models of Inflammatory- And Neuropathic-Induced Mechanical Hypersensitivity in Rats. Molecular Pain 2016. PMID 27899696
• Silver Nanoparticle-Directed Mast Cell Degranulation Is Mediated through Calcium and PI3K Signaling Independent of the High Affinity IgE Receptor. Select Journal Title 2016. PMID 27907088
• Iron Chelators Target Both Proliferating and Quiescent Cancer Cells. Scientific Reports 2016. PMID 27924826
• An N,N-Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A Novel Lanthionine Synthetase C-Like 2-Based Therapeutic for Inflammatory Bowel Disease.. Journal of Medicinal Chemistry 2016. PMID 27933891
• In Silico Discovery and Validation of Amide Based Small Molecule Targeting the Enzymatic Site of Shiga Toxin.. Journal of Medicinal Chemistry 2016. PMID 27933947
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