Learn How our
Libraries and Compounds
are Advancing Research

Browse by Year 2019-2020
2019-2020 Research Articles Citing ChemBridge

Below is a partial list of articles citing the use of ChemBridge libraries and compounds. The list is updated as additional articles are identified. The PMID value can be used to link to the record at the PubMed website.

  • Protein-protein Interactions as Antibiotic Targets: A Medicinal Chemistry Perspective. Medicinal Research Reviews 2020. PMID 30004586
  • Identification of Synthetic Activators of Cancer Cell Migration by Hybrid Deep Learning. ChemBioChem 2020. PMID 31418992
  • Therapeutic Targeting of the PI4K2A/PKR Lysosome Network Is Critical for Misfolded Protein Clearance and Survival in Cancer Cells. Oncogene 2020. PMID 31554935
  • Screening of Antitubercular Compound Library Identifies Inhibitors of Mur Enzymes in Mycobacterium tuberculosis. SLAS Discovery 2020. PMID 31597510
  • Persister Cells Resuscitate via Ribosome Modification by 23S rRNA Pseudouridine Synthase RluD. Environmental Microbiology 2020. PMID 31608580
  • Large-Scale Chemical-Genetic Strategy Enables the Design of Antimicrobial Combination Chemotherapy in Mycobacteria. ACS Infectious Diseases 2020. PMID 31721551
  • Virtual Screening-Driven Discovery of Dual 5-HT 6/5-HT 2A Receptor Ligands With Pro-Cognitive Properties. European Journal of Medicinal Chemistry 2020. PMID 31734022
  • JNK Activation and Translocation to Mitochondria Mediates Mitochondrial Dysfunction and Cell Death Induced by VDAC Opening and Sorafenib in Hepatocarcinoma Cells. Biochemical Pharmacology 2020. PMID 31759978
  • Discovery of an Antivirulence Compound That Reverses beta-Lactam Resistance in MRSA. Nature Chemical Biology 2020. PMID 31768032
  • Paracaspase MALT1 Regulates Glioma Cell Survival by Controlling Endo-Lysosome Homeostasis. The EMBO Journal 2020. PMID 31774199
  • Structure-based Virtual Screening and Biological Evaluation of Novel Non-Bisphosphonate Farnesyl Pyrophosphate Synthase Inhibitors. European Journal of Medicinal Chemistry 2020. PMID 31785819
  • Discovery of Novel Phosphatidylcholine-Specific Phospholipase C Drug-Like Inhibitors as Potential Anticancer Agents. European Journal of Medicinal Chemistry 2020. PMID 31810783
  • A Triazine-Based Analogue of Graphyne: Scalable Synthesis and Applications in Photocatalytic Dye Degradation and Bacterial Inactivation. Chemistry - A European Journal 2020. PMID 31845388
  • CCI52 Sensitizes Tumors to 6-mercaptopurine and Inhibits MYCN-amplified Tumor Growth. Biochemical Pharmacology 2020. PMID 31862449
  • Discovery of benzo[cd]indol-2-one and benzylidene-thiazolidine-2,4-dione as New Classes of NLRP3 Inflammasome Inhibitors via ER-Beta Structure Based Virtual Screening. Bioorganic Chemistry 2020. PMID 31869665
  • Impact of Field Isolate Identified Nonsynonymous Single Nucleotide Polymorphisms on Plasmodium falciparum Equilibrative Nucleoside Transporter 1 Inhibitor Efficacy. ACS Infectious Diseases 2020. PMID 31876139
  • Identification of Mycobacterium Tuberculosis CtpF as a Target for Designing New Antituberculous Compounds. Bioorganic and Medicinal Chemistry Journal 2020. PMID 31879181
  • Anthelmintics in the Future: Current Trends in the Discovery and Development of New Drugs Against Gastrointestinal Nematodes. Drug Discovery Today 2020. PMID 31883953
  • New Potential Drug Leads Against MDR-MTB: A Short Review. Bioorganic Chemistry 2020. PMID 31884135
  • In Silico Design and Analysis of a Kinase-Focused Combinatorial Library Considering Diversity and Quality. Journal of Chemical Information and Modeling 2020. PMID 31886658
  • OT-82, a Novel Anticancer Drug Candidate That Targets the Strong Dependence of Hematological Malignancies on NAD Biosynthesis. Leukemia 2020. PMID 31896781
  • Small Molecule Inhibitor Screen Reveals Calcium Channel Signaling as a Mechanistic Mediator of Clostridium difficile TcdB-Induced Necrosis. ACS Chemical Biology 2020. PMID 31909964
  • Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors. Journal of Medicinal Chemistry 2020. PMID 31910017
  • Current Progress in Antimalarial Pharmacotherapy and Multi-Target Drug Discovery. European Journal of Medicinal Chemistry 2020. PMID 31911292
  • A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors. Journal of Medicinal Chemistry 2020. PMID 31928006
  • Stability and Pharmacokinetics of Separase inhibitor-Sepin-1 in Sprague-Dawley Rats. Biochemical Pharmacology 2020. PMID 31930961
  • Identification and Characterization of a Novel Hepatitis B Virus Pregenomic RNA Encapsidation Inhibitor. Antiviral Research 2020. PMID 31940474
  • Small-Molecule Antagonists of the RIG-I Innate Immune Receptor. ACS Chemical Biology 2020. PMID 31944652
  • Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures. Cell 2020. PMID 32004463
  • Discovery and Optimization of Triazine Nitrile Inhibitors of Toxoplasma gondii Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS. ACS Chemical Neuroscience 2020. PMID 32027110
  • Discovery of Multidrug Efflux Pump Inhibitors With a Novel Chemical Scaffold. Biochimica et Biophysica Acta 2020. PMID 32032658
  • Discovery of Novel 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors by Exploiting a Multistep Virtual Screening Protocol. Journal of Chemical Information and Modeling 2020. PMID 32045233
  • Optimization of 4-Aminopiperidines as Inhibitors of Influenza A Viral Entry That Are Synergistic With Oseltamivir. Journal of Medicinal Chemistry 2020. PMID 32069052
  • Benzothiourea Derivatives Target the Secretory Pathway of the Human Fungal Pathogen Cryptococcus neoformans. ACS Infectious Diseases 2020. PMID 32070095
  • New Frontiers in Drug Discovery: Academia Meets Industry at the International Helmholtz Drug Discovery Conference (HDDC). ChemMedChem 2020. PMID 32080972
  • A Deep Learning Approach to Antibiotic Discovery. Cell 2020. PMID 32084340
  • A Drug Discovery Platform to Identify Compounds That Inhibit EGFR Triple Mutants. Nature Chemical Biology 2020. PMID 32094923
  • Pharmacological LRH-1/Nr5a2 Inhibition Limits Pro-Inflammatory Cytokine Production in Macrophages and Associated Experimental Hepatitis. Cell Death and Disease 2020. PMID 32111818
  • Developing a New Drug Against Trichomoniasis, New Inhibitory Compounds of the Protein Triosephosphate Isomerase. Parasitology International 2020. PMID 32112829
  • Discovery of Sulfonamides and 9-oxo-2,8-diazaspiro[5,5]undecane-2-carboxamides as Human Kynurenine Aminotransferase 2 (KAT2) Inhibitors. Bioorganic and Medicinal Chemistry Letters 2020. PMID 32113843
  • Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase. Journal of Medicinal Chemistry 2020. PMID 32134266
  • Identification of a New Chemotype of Anti-Obesity Compounds by Ensemble Screening. ACS Omega 2020. PMID 32149264
  • HIV-1 Fusion Inhibitors Targeting the Membrane-Proximal External Region of Env Spikes. Nature Chemical Biology 2020. PMID 32152540
  • GTP-binding Inhibitors Increase LRRK2-linked Ubiquitination and Lewy Body-Like Inclusions. Journal of Cell Physiology 2020. PMID 32180220
  • Validation and Characterization of Five Distinct Novel Inhibitors of Human Cytomegalovirus. Journal of Medicinal Chemistry 2020. PMID 32191456
  • Design and Characterization of a Novel Structural Class of Kv1.3 Inhibitors. Bioorganic Chemistry 2020. PMID 32199306
  • Lipidomics-based Assays Coupled With Computational Approaches Can Identify Novel Phospholipase A2 Inhibitors. Advances in Biological Regulation 2020. PMID 32199750
  • Structural Analysis and Identification of False Positive Hits in Luciferase-Based Assays. Journal of Chemical Information and Modeling 2020. PMID 32202787
  • Discovery of Potential Species-Specific Green Insecticides Targeting the Lepidopteran Ryanodine Receptor. Journal of Agricultural and Food Chemistry 2020. PMID 32207934
  • Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability. Journal of Medicinal Chemistry 2020. PMID 32212728
  • Identification of Entry Inhibitors With 4-aminopiperidine Scaffold Targeting Group 1 Influenza A Virus. Antiviral Research 2020. PMID 32222293
  • Pyrazinamide Triggers Degradation of Its Target Aspartate Decarboxylase. Nature Communications 2020. PMID 32245967
  • Computational Chemistry on a Budget: Supporting Drug Discovery With Limited Resources. Journal of Medicinal Chemistry 2020. PMID 32298123
  • Development of a Novel Recombinant Cell Line for Detection and Characterization of Ah Receptor Nuclear Translocation in Intact Cells. Toxicology in Vitro 2020. PMID 32333947
  • Successive Statistical and Structure-Based Modeling to Identify Chemically Novel Kinase Inhibitors. Journal of Chemical Information and Modeling 2020. PMID 32343143
  • Structure-based Discovery of CZL80, a caspase-1 Inhibitor With Therapeutic Potential for Febrile Seizures and Later Enhanced Epileptogenic Susceptibility. British Journal of Pharmacology 2020. PMID 32346861
  • Computer Aided Ligand Based Screening for Identification of Promising Molecules Against Enzymes Involved in Peptidoglycan Biosynthetic Pathway From Acinetobacter Baumannii. Microbial Pathogenesis 2020. PMID 32353580
  • TAK1 Lessens the Activity of the Paracaspase MALT1 During T Cell Receptor Signaling. Cellular Immunology 2020. PMID 32388054
  • Novel and Prevalent non-East Asian ALDH2 Variants; Implications for Global Susceptibility to Aldehydes' Toxicity. EBioMedicine 2020. PMID 32403082
  • F2X-Universal and F2X-Entry: Structurally Diverse Compound Libraries for Crystallographic Fragment Screening. Structure 2020. PMID 32413289
  • Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease. ACS Infectious Diseases 2020. PMID 32428392
  • High-Throughput Screening For The Discovery Of Enzyme Inhibitors. Journal of Medicinal Chemistry 2020. PMID 32432874
  • Frontline Science: CD40 Signaling Restricts RNA Virus Replication in MPhis, Leading to Rapid Innate Immune Control of Acute Virus Infection. Journal of Leukocyte Biology 2020. PMID 32441445
  • Penicillin Binding Protein 2a: An Overview and a Medicinal Chemistry Perspective. European Journal of Medicinal Chemistry 2020. PMID 32442851
  • HDAC1 Dysregulation Induces Aberrant Cell Cycle and DNA Damage in Progress of TDP-43 Proteinopathies. EMBO Molecular Medicine 2020. PMID 32449313
  • The LUBAC Participates in Lysophosphatidic Acid-Induced NF-kappaB Activation. Cellular Immunology 2020. PMID 32450431
  • Cathepsin L-selective Inhibitors: A Potentially Promising Treatment for COVID-19 Patients. Pharmacology and Therapeutics 2020. PMID 32470470
  • Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections. Journal of Medicinal Chemistry 2020. PMID 32490678
  • Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Science Advances 2020. PMID 32494682
  • A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance. Cell 2020. PMID 32497502
  • Discovery of direct-acting antiviral agents with a graphene-based fluorescent nanosensor. Science Advances 2020. PMID 32523995
  • Anticancer Drug Discovery by Targeting Cullin Neddylation. Acta Pharmacologica Sinica 2020. PMID 32528826
  • Molecular Dynamics, MM/PBSA and in Vitro Validation of a Novel Quinazoline-Based EGFR Tyrosine Kinase Inhibitor Identified Using Structure-Based in Silico Screening. Journal of Molecular Graphics and Modelling 2020. PMID 32534372
  • Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion. Advanced Science 2020. PMID 32714746
  • Thermostable small-molecule inhibitor of angiogenesis and vascular permeability that suppresses a pERK-FosB/ΔFosB–VCAM-1 axis. Science Advances 2020. PMID 32923607
  • Anti-inflammatory and antinociceptive effects of the selective cannabinoid CB2 receptor agonist ABK5. Journal of Pharmacological Sciences 2020. PMID 33712283
  • Screening for novel biocontrol agents applicable in plant disease management - A review. Biological Control 2020. PMID N/A
  • Computer-Aided Drug Design for Cancer Therapy. Book Chapter 2020. PMID N/A
  • Potential Site to Direct Selective Compounds in the Triosephosphate Isomerase for the Development of New Drugs. ChemistrySelect 2020. PMID N/A
  • High-throughput screening reveals small molecule modulators inhibitory to Acidovorax citrulli. Plant Pathology 2020. PMID N/A
  • Machine-learning scoring functions for structure-based virtual screening. WIREs Computational Molecular Science 2020. PMID N/A
  • Glucose-derived acetate and ACSS2 as key players in cisplatin resistance in bladder cancer. Biochimica et Biophysica Acta 2019. PMID 29883801
  • Antifungal drugs: New insights in research & development. Pharmacology and Therapeutics 2019. PMID 30347212
  • Structure-based Pharmacophore Models to Probe Anticancer Activity of Inhibitors of Protein Kinase B-beta (PKB Beta). Chemical Biology and Drug Design 2019. PMID 30354009
  • Gossypetin is a novel MKK3 and MKK6 inhibitor that suppresses esophageal cancer growth in vitro and in vivo. Cancer Letters 2019. PMID 30391783
  • Evolution of commercially available compounds for HTS. Drug Discovery Today 2019. PMID 30399443
  • From bench to bedside, via desktop. Recent advances in the application of cutting-edge in silico tools in the research of drugs targeting bromodomain modules. Biochemical Pharmacology 2019. PMID 30414936
  • INH14, a Small-Molecule Urea Derivative, Inhibits the IKKAlpha/Beta-Dependent TLR Inflammatory Response. ChemBioChem 2019. PMID 30447158
  • Small molecules as inhibitors of PCSK9: Current status and future challenges. European Journal of Medicinal Chemistry 2019. PMID 30448414
  • Halogen Substituents in the Isoquinoline Scaffold Switches the Selectivity of Inhibition Between USP2 and USP7. ChemBioChem 2019. PMID 30474907
  • Discovery and Characterization of Two Classes of Selective Inhibitors of the Suppressor of the TCR Signaling Family of Proteins. ACS Infectious Diseases 2019. PMID 30485744
  • Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors. Bioorganic and Medicinal Chemistry Letters 2019. PMID 30522956
  • Inhibition of CPAP-tubulin Interaction Prevents Proliferation of Centrosome-Amplified Cancer Cells. The EMBO Journal 2019. PMID 30530478
  • Discovery of new potent hits against intracellular Trypanosoma cruzi by QSAR-based virtual screening. European Journal of Medicinal Chemistry 2019. PMID 30562700
  • Development and Testing of Druglike Screening Libraries. Journal of Chemical Information and Modeling 2019. PMID 30563329
  • Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's and Parkinson disease pathology. Biochimica et Biophysica Acta 2019. PMID 30572013
  • NAOMInext - Synthetically feasible fragment growing in a structure-based design context. European Journal of Medicinal Chemistry 2019. PMID 30576905
  • Dengue drug discovery: Progress, challenges and outlook. Antiviral Research 2019. PMID 30597183
  • Virtual Screening With a Structure-Based Pharmacophore Model to Identify Small-Molecule Inhibitors of CARM1. Journal of Chemical Information and Modeling 2019. PMID 30607947
  • Identification of substituted 5-membered heterocyclic compounds as potential anti-leukemic agents. European Journal of Medicinal Chemistry 2019. PMID 30611980
  • Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1. ACS Chemical Biology 2019. PMID 30620551
  • Mycobacterium tuberculosis virulence inhibitors discovered by Mycobacterium marinum high-throughput screening. Scientific Reports 2019. PMID 30631100
  • Crystal Structure of the Human Cannabinoid Receptor CB2. Cell 2019. PMID 30639103
  • Approved drugs screening against the nsP1 capping enzyme of Venezuelan equine encephalitis virus using an immuno-based assay. Antiviral Research 2019. PMID 30639438
  • Computational in Vitro Toxicology Uncovers Chemical Structures Impairing Mitochondrial Membrane Potential. Journal of Chemical Information and Modeling 2019. PMID 30645939
  • Chemical Genetic Identification of a Lectin Receptor Kinase That Transduces Immune Responses and Interferes With Abscisic Acid Signaling. The Plant Journal 2019. PMID 30659683
  • Investigation of novel chemical scaffolds targeting prolyl oligopeptidase for neurological therapeutics. Journal of Molecular Graphics and Modelling 2019. PMID 30665156
  • Discovery and evaluation of inhibitor of LARP6 as specific antifibrotic compound. Scientific Reports 2019. PMID 30674965
  • Discovery of Small-Molecule Antibiotics Against a Unique tRNA-Mediated Regulation of Transcription in Gram-Positive Bacteria. ChemMedChem 2019. PMID 30707489
  • Synthesis and Biological Evaluation of 3-Arylindazoles as Selective MEK4 Inhibitors. ChemMedChem 2019. PMID 30707493
  • A simple fluorescent assay for the discovery of protein-protein interaction inhibitors. Analytical Biochemistry 2019. PMID 30707898
  • The catalytic activity and secretion of zebrafish RNases are essential for their in vivo function in motor neurons and vasculature. Scientific Reports 2019. PMID 30710110
  • The inhibitor apoptosis protein antagonist Debio 1143 Is an attractive HIV-1 latency reversal candidate. PLoS ONE 2019. PMID 30716099
  • Small-molecule allosteric inhibitors of BAX. Nature Chemical Biology 2019. PMID 30718816
  • Small-Molecule Agonists of Ae. aegypti Neuropeptide Y Receptor Block Mosquito Biting. Cell 2019. PMID 30735632
  • Functionalized Phenylbenzamides Inhibit Aquaporin-4 Reducing Cerebral Edema and Improving Outcome in Two Models of CNS Injury. Neuroscience 2019. PMID 30738082
  • Development of a non-radioactive screening assay to detect chemicals disrupting the human sodium iodide symporter activity. Toxicology in Vitro 2019. PMID 30738889
  • Coupling reactions between reduced intermediates of insensitive munitions compound analog 4-nitroanisole. Chemosphere 2019. PMID 30739063
  • Identification of glucosyl-3-phosphoglycerate phosphatase as a novel drug target against resistant strain of Mycobacterium tuberculosis (XDR1219) by using comparative metabolic pathway approach. Computational Biology and Chemistry 2019. PMID 30743161
  • Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model. Journal of Medicinal Chemistry 2019. PMID 30763102
  • Molecular Characterization of Mucus Binding. Biomacromolecules 2019. PMID 30779551
  • Allosteric Modulator Discovery: From Serendipity to Structure-Based Design. Journal of Medicinal Chemistry 2019. PMID 30817889
  • Rational design of allosteric modulators of the aromatase enzyme: An unprecedented therapeutic strategy to fight breast cancer. European Journal of Medicinal Chemistry 2019. PMID 30822713
  • Virtual screening identification of novel chemical inhibitors for aberrant interactions between pathogenic mutant SOD1 and tubulin. Neurochemistry International 2019. PMID 30831216
  • Neuroprotective Effects of BHDPC, a Novel Neuroprotectant, on Experimental Stroke by Modulating Microglia Polarization. Select Journal Title 2019. PMID 30839193
  • Macropinocytosis contributes to hantavirus entry into human airway epithelial cells. Virology 2019. PMID 30852272
  • Meeting Proceedings From ICBS 2018- Toward Translational Impact. ACS Chemical Biology 2019. PMID 30860357
  • A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Reports 2019. PMID 30865894
  • Novel narrow spectrum benzyl thiophene sulfonamide derivatives to control Campylobacter. The Journal of Antibiotics 2019. PMID 30918323
  • Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold. European Journal of Medicinal Chemistry 2019. PMID 30921693
  • Identification of Thienopyrimidine Scaffold as an Inhibitor of the ABC Transport Protein ABCC1 (MRP1) and Related Transporters Using a Combined Virtual Screening Approach. Journal of Medicinal Chemistry 2019. PMID 30925062
  • Synthetic ligands for PreQ1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure.. Nature Communications 2019. PMID 30940810
  • Identification of Allosteric Inhibitors against Active Caspase-6.. Scientific Reports 2019. PMID 30940883
  • Identification and biochemical analyses of selective CB2 agonists. European Journal of Pharmacology 2019. PMID 30951717
  • Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging. Cell Reports 2019. PMID 30970250
  • Tricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns. Cell Reports 2019. PMID 30970255
  • Design of Natural-Product-Inspired Multitarget Ligands by Machine Learning. ChemMedChem 2019. PMID 30973672
  • Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies. European Journal of Medicinal Chemistry 2019. PMID 30986571
  • Kinetic and Molecular Dynamic Studies of Inhibitors of Shikimate Dehydrogenase From Methicillin-Resistant Staphylococcus Aureus. Chemical Biology and Drug Design 2019. PMID 31009175
  • Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nature Chemical Biology 2019. PMID 31011214
  • Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network. PLOS Computational Biology 2019. PMID 31026276
  • Discovery of a Small Molecule Promoting Mouse and Human Osteoblast Differentiation via Activation of p38 MAPK-Beta. Cell Chemical Biology 2019. PMID 31031140
  • A Role for the Auxin Precursor Anthranilic Acid in Root Gravitropism via Regulation of PIN-FORMED Protein Polarity and Relocalisation in Arabidopsis. New Phytologist 2019. PMID 31038751
  • K-RasG12D Has a Potential Allosteric Small Molecule Binding Site. Biochemistry 2019. PMID 31042025
  • Dual role of D-amino acid oxidase in experimental pain models. European Journal of Pharmacology 2019. PMID 31059710
  • Identification of a potential allosteric site of Golgi Alpha-mannosidase II using computer-aided drug design. PLoS ONE 2019. PMID 31067280
  • Redox TRPs in diabetes and diabetic complications: Mechanisms and pharmacological modulation. Pharmacological Research 2019. PMID 31096011
  • Discovery of CDK5 Inhibitors Through Structure-Guided Approach. ACS Medicinal Chemistry Letters 2019. PMID 31098000
  • Targeting the Shc-EGFR interaction with indomethacin inhibits MAP kinase pathway signalling. Cancer Letters 2019. PMID 31100409
  • Spirocycles as Rigidified Sp3-Rich Scaffolds for a Fragment Collection. Organic Letters 2019. PMID 31145629
  • Development and optimization of a high-throughput screening method utilizing Ancylostoma ceylanicum egg hatching to identify novel anthelmintics. PLoS ONE 2019. PMID 31158236
  • Mitochondrial Complex I Inhibitor Deguelin Induces Metabolic Reprogramming and Sensitizes Vemurafenib-Resistant BRAF V600E Mutation Bearing Metastatic Melanoma Cells. Molecular Carcinogenesis 2019. PMID 31211467
  • A challenge finding P2X1 and P2X4 ligands. Neuropharmacology 2019. PMID 31238045
  • Small Molecule Targeting TDP-43's RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS). ACS Chemical Biology 2019. PMID 31241884
  • Identifying small molecule probes of ENTPD5 through high throughput screening. PLoS ONE 2019. PMID 31242188
  • Discovery of Novel Mnk Inhibitors Using Mutation-Based Induced-Fit Virtual High-Throughput Screening. Chemical Biology and Drug Design 2019. PMID 31260185
  • Identification and characterization of a novel chemotype for human TLR8 inhibitors. European Journal of Medicinal Chemistry 2019. PMID 31284084
  • Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system. Scientific Reports 2019. PMID 31285509
  • Evaluation of in silico designed inhibitors targeting MelF (Rv1936) against Mycobacterium marinum within macrophages.. Scientific Reports 2019. PMID 31300732
  • MRP1 modulators synergize with buthionine sulfoximine to exploit collateral sensitivity and selectively kill MRP1-expressing cancer cells. Biochemical Pharmacology 2019. PMID 31302132
  • Substituted anthraquinones represent a potential scaffold for DNA methyltransferase 1-specific inhibitors. PLoS ONE 2019. PMID 31306451
  • Boosting NAD+ with a small molecule that activates NAMPT. Nature Communications 2019. PMID 31324777
  • The Orphan Nuclear Receptor LRH-1/NR5a2 Critically Regulates T Cell Functions. Science Advances 2019. PMID 31328159
  • Methods to identify and optimize small molecules interacting with RNA (SMIRNAs). Drug Discovery Today 2019. PMID 31356880
  • Virtual Pharmacophore Screening Identifies Small-Molecule Inhibitors of the Rev1-CT/RIR Protein-Protein Interaction. ChemMedChem 2019. PMID 31361935
  • Noncompetitive Inhibitors of TNFR1 Probe Conformational Activation States. Science Signaling 2019. PMID 31363069
  • Identification via a Parallel Hit Progression Strategy of Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter That Inhibit Plasmodium falciparum Parasite Proliferation. ACS Infectious Diseases 2019. PMID 31373203
  • PTP-sigma inhibitors promote hematopoietic stem cell regeneration.. Nature Communications 2019. PMID 31413255
  • Exposing Small-Molecule Nanoentities by a Nuclear Magnetic Resonance Relaxation Assay. Journal of Medicinal Chemistry 2019. PMID 31422659
  • How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using N-Myristoyltransferases as a Model System. Journal of Medicinal Chemistry 2019. PMID 31423787
  • Synthesis, Identification, and Structure-Activity Relationship Analysis of GATA4 and NKX2-5 Protein-Protein Interaction Modulators. Journal of Medicinal Chemistry 2019. PMID 31431011
  • Targeting Tumor Phenotypic Plasticity and Metabolic Remodeling in Adaptive Cross-Drug Tolerance. Science Signaling 2019. PMID 31431543
  • Landscape of ROD9 Island: Functional annotations and biological network of hypothetical proteins in Salmonella enterica. Computational Biology and Chemistry 2019. PMID 31445418
  • An Influenza Virus Entry Inhibitor Targets Class II PI3 Kinase and Synergizes With Oseltamivir. ACS Infectious Diseases 2019. PMID 31448902
  • Cell-based high throughput screening identified a novel compound that promotes regulatory T cells and prevents autoimmune colitis. Biochemical Pharmacology 2019. PMID 31449782
  • Computational and Experimental Druggability Assessment of Human DNA Glycosylases. ACS Omega 2019. PMID 31460271
  • The Marginal Cells of the Caenorhabditis Elegans Pharynx Scavenge Cholesterol and Other Hydrophobic Small Molecules. Nature Communications 2019. PMID 31477732
  • Zebrafish Behavioural Profiling Identifies GABA and Serotonin Receptor Ligands Related to Sedation and Paradoxical Excitation. Nature Communications 2019. PMID 31501447
  • Integrated Transcriptomics Reveals Master Regulators of Lung Adenocarcinoma and Novel Repositioning of Drug Candidates. Cancer Medicine 2019. PMID 31503425
  • Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies. Cell Chemical Biology 2019. PMID 31521622
  • PML Hyposumoylation Is Responsible for the Resistance of Pancreatic Cancer. The FASEB Journal 2019. PMID 31557059
  • Targeted 8-hydroxyquinoline fragment based small molecule drug discovery against neglected botulinum neurotoxin type F. Bioorganic Chemistry 2019. PMID 31557621
  • Modeling MEK4 Kinase Inhibitors Through Perturbed Electrostatic Potential Charges. Journal of Chemical Information and Modeling 2019. PMID 31566378
  • Identification and Structure-Activity Relationship Study of Imidazo[1,2- a]pyridine-3-amines as First Selective Inhibitors of Excitatory Amino Acid Transporter Subtype 3 (EAAT3). ACS Chemical Neuroscience 2019. PMID 31573179
  • A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Reports 2019. PMID 31577956
  • Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer. Cell Reports 2019. PMID 31577957
  • Development of New Methods Needs Proper Evaluation-Benchmarking Sets for Machine Learning Experiments for Class A GPCRs. Journal of Chemical Information and Modeling 2019. PMID 31604014
  • Employing a ZTP Riboswitch to Detect Bacterial Folate Biosynthesis Inhibitors in a Small Molecule High-Throughput Screen. ACS Chemical Biology 2019. PMID 31609568
  • Effective Virtual Screening Strategy toward heme-containing proteins: Identification of novel IDO1 inhibitors. European Journal of Medicinal Chemistry 2019. PMID 31610376
  • Understanding the Language of Drugged Plants. Nature Chemical Biology 2019. PMID 31636434
  • A Biomimetic, One-Step Transformation of Simple Indolic Compounds to Malassezia-Related Alkaloids With High AhR Potency and Efficacy. Chemical Research in Toxicology 2019. PMID 31647221
  • Identifying Anti-prion Chemical Compounds Using a Newly Established Yeast High-Throughput Screening System. Cell Chemical Biology 2019. PMID 31668517
  • Identification of a new small molecule chemotype of Melanin Concentrating Hormone Receptor-1 antagonists using pharmacophore-based virtual screening. Bioorganic and Medicinal Chemistry Letters 2019. PMID 31678007
  • Discovery of Holoenzyme-Disrupting Chemicals as Substrate-Selective CK2 Inhibitors. Scientific Reports 2019. PMID 31685885
  • A Selective Ligand for Estrogen Receptor Proteins Discriminates Rapid and Genomic Signaling. Cell Chemical Biology 2019. PMID 31706983
  • Selective Activation of TWIK-related Acid-Sensitive K + 3 Subunit-Containing Channels Is Analgesic in Rodent Models. Science Translational Medicine 2019. PMID 31748231
  • Molecular docking study of lamellarin analogues and identification of potential inhibitors of HIV-1 integrase strand transfer complex by virtual screening. Heliyon 2019. PMID 31763475
  • The Complex of Plasmodium Falciparum falcipain-2 Protease With an (E)-chalcone-based Inhibitor Highlights a Novel, Small, Molecule-Binding Site. Malaria Journal 2019. PMID 31791339
  • Synthesis of Histidine Kinase Inhibitors and Their Biological Properties. Medicinal Research Reviews 2019. PMID 31802520
  • Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening. PLoS ONE 2019. PMID 31851699
  • Bayesian Machine Learning to Discover Bruton's Tyrosine Kinase (BTK) Inhibitors. Chemical Biology and Drug Design 2019. PMID 31855311
  • Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1. ACS Omega 2019. PMID 31956833
  • Identification and Screening of Selective WEE2 Inhibitors to Develop Non-Hormonal Contraceptives That Specifically Target Meiosis. ChemistrySelect 2019. PMID 32190728