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Recent Research Articles Citing ChemBridge Libraries and Compounds

New articles appear monthly citing the use of ChemBridge libraries and compounds in a wide range of research areas. The articles below represent some of the most recent work published that cites the use of ChemBridge libraries or compounds in chemical biology research, drug discovery research, and other research areas.

For a more complete list of recent and past articles, visit the Browse by Year page.

Partial List of Articles from the Past 12 Months
  • APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia. Science Translational Medicine 2021. PMID 33658354
  • A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma. Oncogene 2021. PMID 33658627
  • A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-alpha Release in Human Lymphoblasts. Cells 2021. PMID 33672296
  • A cell-based screening method using an intracellular antibody for discovering small molecules targeting the translocation protein LMO2. Science Advances 2021. PMID 33837087
  • Combining generative artificial intelligence and on-chip synthesis for de novo drug design. Science Advances 2021. PMID 34117066
  • Development of a Novel Recombinant Cell Line for Detection and Characterization of Ah Receptor Nuclear Translocation in Intact Cells. Toxicology in Vitro 2020. PMID 32333947
  • The LUBAC Participates in Lysophosphatidic Acid-Induced NF-kappaB Activation. Cellular Immunology 2020. PMID 32450431
  • Thermostable small-molecule inhibitor of angiogenesis and vascular permeability that suppresses a pERK-FosB/ΔFosB–VCAM-1 axis. Science Advances 2020. PMID 32923607
  • Anti-inflammatory and antinociceptive effects of the selective cannabinoid CB2 receptor agonist ABK5. Journal of Pharmacological Sciences 2020. PMID 33712283
  • Protein-protein Interactions as Antibiotic Targets: A Medicinal Chemistry Perspective. Medicinal Research Reviews 2020. PMID 30004586
  • Identification of Synthetic Activators of Cancer Cell Migration by Hybrid Deep Learning. ChemBioChem 2020. PMID 31418992
  • Therapeutic Targeting of the PI4K2A/PKR Lysosome Network Is Critical for Misfolded Protein Clearance and Survival in Cancer Cells. Oncogene 2020. PMID 31554935
  • Screening of Antitubercular Compound Library Identifies Inhibitors of Mur Enzymes in Mycobacterium tuberculosis. SLAS Discovery 2020. PMID 31597510
  • Persister Cells Resuscitate via Ribosome Modification by 23S rRNA Pseudouridine Synthase RluD. Environmental Microbiology 2020. PMID 31608580
  • Large-Scale Chemical-Genetic Strategy Enables the Design of Antimicrobial Combination Chemotherapy in Mycobacteria. ACS Infectious Diseases 2020. PMID 31721551
  • Virtual Screening-Driven Discovery of Dual 5-HT 6/5-HT 2A Receptor Ligands With Pro-Cognitive Properties. European Journal of Medicinal Chemistry 2020. PMID 31734022
  • JNK Activation and Translocation to Mitochondria Mediates Mitochondrial Dysfunction and Cell Death Induced by VDAC Opening and Sorafenib in Hepatocarcinoma Cells. Biochemical Pharmacology 2020. PMID 31759978
  • Discovery of an Antivirulence Compound That Reverses beta-Lactam Resistance in MRSA. Nature Chemical Biology 2020. PMID 31768032
  • Paracaspase MALT1 Regulates Glioma Cell Survival by Controlling Endo-Lysosome Homeostasis. The EMBO Journal 2020. PMID 31774199
  • Structure-based Virtual Screening and Biological Evaluation of Novel Non-Bisphosphonate Farnesyl Pyrophosphate Synthase Inhibitors. European Journal of Medicinal Chemistry 2020. PMID 31785819
  • Discovery of Novel Phosphatidylcholine-Specific Phospholipase C Drug-Like Inhibitors as Potential Anticancer Agents. European Journal of Medicinal Chemistry 2020. PMID 31810783
  • A Triazine-Based Analogue of Graphyne: Scalable Synthesis and Applications in Photocatalytic Dye Degradation and Bacterial Inactivation. Chemistry - A European Journal 2020. PMID 31845388
  • CCI52 Sensitizes Tumors to 6-mercaptopurine and Inhibits MYCN-amplified Tumor Growth. Biochemical Pharmacology 2020. PMID 31862449
  • Discovery of benzo[cd]indol-2-one and benzylidene-thiazolidine-2,4-dione as New Classes of NLRP3 Inflammasome Inhibitors via ER-Beta Structure Based Virtual Screening. Bioorganic Chemistry 2020. PMID 31869665
  • Impact of Field Isolate Identified Nonsynonymous Single Nucleotide Polymorphisms on Plasmodium falciparum Equilibrative Nucleoside Transporter 1 Inhibitor Efficacy. ACS Infectious Diseases 2020. PMID 31876139
  • Identification of Mycobacterium Tuberculosis CtpF as a Target for Designing New Antituberculous Compounds. Bioorganic and Medicinal Chemistry Journal 2020. PMID 31879181
  • Anthelmintics in the Future: Current Trends in the Discovery and Development of New Drugs Against Gastrointestinal Nematodes. Drug Discovery Today 2020. PMID 31883953
  • New Potential Drug Leads Against MDR-MTB: A Short Review. Bioorganic Chemistry 2020. PMID 31884135
  • In Silico Design and Analysis of a Kinase-Focused Combinatorial Library Considering Diversity and Quality. Journal of Chemical Information and Modeling 2020. PMID 31886658
  • OT-82, a Novel Anticancer Drug Candidate That Targets the Strong Dependence of Hematological Malignancies on NAD Biosynthesis. Leukemia 2020. PMID 31896781
  • Small Molecule Inhibitor Screen Reveals Calcium Channel Signaling as a Mechanistic Mediator of Clostridium difficile TcdB-Induced Necrosis. ACS Chemical Biology 2020. PMID 31909964
  • Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors. Journal of Medicinal Chemistry 2020. PMID 31910017
  • Current Progress in Antimalarial Pharmacotherapy and Multi-Target Drug Discovery. European Journal of Medicinal Chemistry 2020. PMID 31911292
  • A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors. Journal of Medicinal Chemistry 2020. PMID 31928006
  • Stability and Pharmacokinetics of Separase inhibitor-Sepin-1 in Sprague-Dawley Rats. Biochemical Pharmacology 2020. PMID 31930961
  • Identification and Characterization of a Novel Hepatitis B Virus Pregenomic RNA Encapsidation Inhibitor. Antiviral Research 2020. PMID 31940474
  • Small-Molecule Antagonists of the RIG-I Innate Immune Receptor. ACS Chemical Biology 2020. PMID 31944652
  • Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures. Cell 2020. PMID 32004463
  • Discovery and Optimization of Triazine Nitrile Inhibitors of Toxoplasma gondii Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS. ACS Chemical Neuroscience 2020. PMID 32027110
  • Discovery of Multidrug Efflux Pump Inhibitors With a Novel Chemical Scaffold. Biochimica et Biophysica Acta 2020. PMID 32032658
  • Discovery of Novel 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors by Exploiting a Multistep Virtual Screening Protocol. Journal of Chemical Information and Modeling 2020. PMID 32045233
  • Optimization of 4-Aminopiperidines as Inhibitors of Influenza A Viral Entry That Are Synergistic With Oseltamivir. Journal of Medicinal Chemistry 2020. PMID 32069052
  • Benzothiourea Derivatives Target the Secretory Pathway of the Human Fungal Pathogen Cryptococcus neoformans. ACS Infectious Diseases 2020. PMID 32070095
  • New Frontiers in Drug Discovery: Academia Meets Industry at the International Helmholtz Drug Discovery Conference (HDDC). ChemMedChem 2020. PMID 32080972
  • A Deep Learning Approach to Antibiotic Discovery. Cell 2020. PMID 32084340
  • A Drug Discovery Platform to Identify Compounds That Inhibit EGFR Triple Mutants. Nature Chemical Biology 2020. PMID 32094923
  • Pharmacological LRH-1/Nr5a2 Inhibition Limits Pro-Inflammatory Cytokine Production in Macrophages and Associated Experimental Hepatitis. Cell Death and Disease 2020. PMID 32111818
  • Developing a New Drug Against Trichomoniasis, New Inhibitory Compounds of the Protein Triosephosphate Isomerase. Parasitology International 2020. PMID 32112829
  • Discovery of Sulfonamides and 9-oxo-2,8-diazaspiro[5,5]undecane-2-carboxamides as Human Kynurenine Aminotransferase 2 (KAT2) Inhibitors. Bioorganic and Medicinal Chemistry Letters 2020. PMID 32113843
  • Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase. Journal of Medicinal Chemistry 2020. PMID 32134266
  • Identification of a New Chemotype of Anti-Obesity Compounds by Ensemble Screening. ACS Omega 2020. PMID 32149264
  • HIV-1 Fusion Inhibitors Targeting the Membrane-Proximal External Region of Env Spikes. Nature Chemical Biology 2020. PMID 32152540
  • GTP-binding Inhibitors Increase LRRK2-linked Ubiquitination and Lewy Body-Like Inclusions. Journal of Cell Physiology 2020. PMID 32180220
  • Validation and Characterization of Five Distinct Novel Inhibitors of Human Cytomegalovirus. Journal of Medicinal Chemistry 2020. PMID 32191456
  • Design and Characterization of a Novel Structural Class of Kv1.3 Inhibitors. Bioorganic Chemistry 2020. PMID 32199306
  • Lipidomics-based Assays Coupled With Computational Approaches Can Identify Novel Phospholipase A2 Inhibitors. Advances in Biological Regulation 2020. PMID 32199750
  • Structural Analysis and Identification of False Positive Hits in Luciferase-Based Assays. Journal of Chemical Information and Modeling 2020. PMID 32202787
  • Discovery of Potential Species-Specific Green Insecticides Targeting the Lepidopteran Ryanodine Receptor. Journal of Agricultural and Food Chemistry 2020. PMID 32207934
  • Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability. Journal of Medicinal Chemistry 2020. PMID 32212728
  • Identification of Entry Inhibitors With 4-aminopiperidine Scaffold Targeting Group 1 Influenza A Virus. Antiviral Research 2020. PMID 32222293
  • Pyrazinamide Triggers Degradation of Its Target Aspartate Decarboxylase. Nature Communications 2020. PMID 32245967
  • Computational Chemistry on a Budget: Supporting Drug Discovery With Limited Resources. Journal of Medicinal Chemistry 2020. PMID 32298123
  • Successive Statistical and Structure-Based Modeling to Identify Chemically Novel Kinase Inhibitors. Journal of Chemical Information and Modeling 2020. PMID 32343143
  • Structure-based Discovery of CZL80, a caspase-1 Inhibitor With Therapeutic Potential for Febrile Seizures and Later Enhanced Epileptogenic Susceptibility. British Journal of Pharmacology 2020. PMID 32346861
  • Computer Aided Ligand Based Screening for Identification of Promising Molecules Against Enzymes Involved in Peptidoglycan Biosynthetic Pathway From Acinetobacter Baumannii. Microbial Pathogenesis 2020. PMID 32353580
  • TAK1 Lessens the Activity of the Paracaspase MALT1 During T Cell Receptor Signaling. Cellular Immunology 2020. PMID 32388054
  • Novel and Prevalent non-East Asian ALDH2 Variants; Implications for Global Susceptibility to Aldehydes' Toxicity. EBioMedicine 2020. PMID 32403082
  • F2X-Universal and F2X-Entry: Structurally Diverse Compound Libraries for Crystallographic Fragment Screening. Structure 2020. PMID 32413289
  • Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease. ACS Infectious Diseases 2020. PMID 32428392
  • High-Throughput Screening For The Discovery Of Enzyme Inhibitors. Journal of Medicinal Chemistry 2020. PMID 32432874
  • Frontline Science: CD40 Signaling Restricts RNA Virus Replication in MPhis, Leading to Rapid Innate Immune Control of Acute Virus Infection. Journal of Leukocyte Biology 2020. PMID 32441445
  • Penicillin Binding Protein 2a: An Overview and a Medicinal Chemistry Perspective. European Journal of Medicinal Chemistry 2020. PMID 32442851
  • HDAC1 Dysregulation Induces Aberrant Cell Cycle and DNA Damage in Progress of TDP-43 Proteinopathies. EMBO Molecular Medicine 2020. PMID 32449313
  • Cathepsin L-selective Inhibitors: A Potentially Promising Treatment for COVID-19 Patients. Pharmacology and Therapeutics 2020. PMID 32470470
  • Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections. Journal of Medicinal Chemistry 2020. PMID 32490678
  • Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Science Advances 2020. PMID 32494682
  • A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance. Cell 2020. PMID 32497502
  • Discovery of direct-acting antiviral agents with a graphene-based fluorescent nanosensor. Science Advances 2020. PMID 32523995
  • Anticancer Drug Discovery by Targeting Cullin Neddylation. Acta Pharmacologica Sinica 2020. PMID 32528826
  • Molecular Dynamics, MM/PBSA and in Vitro Validation of a Novel Quinazoline-Based EGFR Tyrosine Kinase Inhibitor Identified Using Structure-Based in Silico Screening. Journal of Molecular Graphics and Modelling 2020. PMID 32534372
  • Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion. Advanced Science 2020. PMID 32714746
  • Computer-Aided Drug Design for Cancer Therapy. Book Chapter 2020. PMID N/A
  • Screening for novel biocontrol agents applicable in plant disease management - A review. Biological Control 2020. PMID N/A
  • Machine-learning scoring functions for structure-based virtual screening. WIREs Computational Molecular Science 2020. PMID N/A
  • Potential Site to Direct Selective Compounds in the Triosephosphate Isomerase for the Development of New Drugs. ChemistrySelect 2020. PMID N/A
  • High-throughput screening reveals small molecule modulators inhibitory to Acidovorax citrulli. Plant Pathology 2020. PMID N/A