More than 1.3 Million
Small Molecules, Macrocycles
and Fragments for
 Hit Generation

High Quality, Small Molecule, Lead-like and Drug-like Screening Compounds

ChemBridge has been a provider of high quality screening compounds and libraries for hit identification for almost three decades and continues to produce novel, lead-like and drug-like small molecule screening compounds based on the evolving requirements of drug discovery and chemical biology researchers in industry and academia. We currently offer more than 1.3 million small molecule screening compounds that are readily available from stock that can be custom-selected and formatted according to your requirements. New compounds based on novel ChemBridge designs are added every year to our growing stock. Our stock is composed of two complementary parts with no overlap:

Researchers can custom select compounds based on their own requirements or ChemBridge can assist with compound selection. Compounds can be delivered in mg or micromole amounts in a wide range of formats, and plating in customer-specified materials is available. For researchers interested in chemical diversity for use across a range of targets or for exploring novel targets, ChemBridge also offers pre-plated diversity libraries that offer a lower cost per compound compared to custom selections. We also offer a number of targeted and focused sets representing compounds selected from our stock using computational and informatics methods.

Our stock can be searched online by ChemBridge ID or structure at ChemBridge’s Search and Order site. Researchers can also access structure files for our small molecule screening compounds. When considering a larger compound acquisition (1,000 or more compounds), ChemBridge can prepare custom files that include only compounds available from Regular stock at your preferred amount per compound to ensure the highest availability. For virtual screening and structure searching, ChemBridge can provides files that include structures available at both higher and lower stock levels.

View the Screening Compounds product sheet

CORE Library Stock

Our in-house designed CORE Library Stock of sp3-enriched, lead-like, small molecule screening compounds (8-digit IDs) offers more than 870,000 compounds. These high quality compounds are designed and synthesized by ChemBridge and are based on more than 1,000 proprietary, synthetic schemes. To maximize novelty and diversity, our template and final compound designs draw from ChemBridge’s internal Building Block Collection, from external building block sources, and from new reagents designed by ChemBridge. New compounds based on novel designs are added to the CORE Library Stock each year.

These compounds are designed to cover unique chemical space not available from our EXPRESS-Pick™ Stock or other commercial sources. Final compound designs are assessed virtually prior to synthesis and only compounds with the most attractive physiochemical property profile and free of undesirable chemical functionalities are synthesized and added to the CORE Library Stock. Because of the lead-like properties of these compounds, more than half of all CORE Library Stock compounds are suitable for CNS focused research and are included in the CNS-MPO Library selection.

Physiochemical property averages are:

  • Average Molecular Weight: 344
  • Average H-bond Donor Count: 1.1
  • Average H-bond Acceptor Count: 4.1
  • Average clogP: 1.6
  • Average TPSA : 68.7
  • Average Rotatable Bond Count: 4.9
  • Average Fsp3: 0.46
EXPRESS-Pick Stock

The EXPRESS-Pick Stock (7-digit IDs) contains 500,000 small molecule screening compounds. Compounds were selected using novelty, diversity, drug-like property, and chemical structure analyses. Because chemical space covered by the EXPRESS-Pick Stock is different than the chemical space covered by the CORE Library Stock, the EXPRESS-Pick Stock provides access to additional chemotypes for hit finding. Both drug-like and lead-like compounds are represented in the EXPRESS-Pick Stock.

Physiochemical property averages are:

  • Average Molecular Weight: 355
  • Average H-bond Donor Count: 1.1
  • Average H-bond Acceptor Count: 3.8
  • Average clogP: 3.6
  • Average TPSA : 66.8
  • Average Rotatable Bond Count: 3.8

Almost three decades of excellence as a small molecule library and compound provider and chemistry service provider/partner, including major, multi-year alliances with top pharmaceutical companies.


Over 30 million samples provided to customers worldwide, including all major pharmaceutical and biotechnology companies as well as major academic and non-profit research organizations.

Successful HTS Campaigns

More than 7,000 publications reference the use of ChemBridge libraries or compounds including articles in leading scientific journals including Science, Nature Cell Biology, JACS, PNAS, JBC, Cancer Research, and many others.

  • Custom select compounds according to your requirements
  • Available in 384-well or 96-well format plates and racks, including acoustic qualified plates
  • Available as DMSO solutions or dry
  • Formatting according to your requirements in ChemBridge standard or customer specified materials
Structure Files

For a file of structures, please contact ChemBridge Sales.