Targeted and
Specialty Libraries

Peptide Beta Turn Mimetic Compounds for GPCR Research

The GPCR Library comprises over 8,000 novel, scaffold-based compounds designed using a series of
GPCR-relevant scaffolds that mimic the beta-turn motif of endogenous peptide ligands. A random
selection taken from the entire GPCR Library have been validated against GPCR targets with both
agonists and antagonists being identified. Clients can custom select compounds from the GPCR Library.

  • Lead-like and Drug-like compounds based on novel scaffolds
  • Custom select from more than 5,000 compounds

GPCR Library compounds are lead-like and drug-like and have the following physiochemical and
calculated property averages:

  • Molecular Weight Average: 417
  • Fsp3: Average: 0.5
  • clogP Average: 2.6
  • TPSA Average: 73
  • H-bond Donor Count Average: 1.1
  • H-bond Acceptor Count: Average = 4.7
  • Rotatable Bound Count Average: 5.3
  • Download structures and custom select compounds from the GPCR Library SDfile
  • Compounds can be provided in 96-well and 384-well format
  • Available in 96-well or 384-well format including acoustic compatible plates
  • Amounts as low as 0.25 micromole (25ul of 10mM DMSO solution) available
  • Compounds are available as DMSO solutions or dry in micromole or mg amounts

For more information or a file of compound structures, please contact ChemBridge Sales