Targeted and
Specialty Libraries

GPCR
Peptide Beta Turn Mimetic Compounds for GPCR Research

The GPCR Library comprises over 8,000 novel, scaffold-based compounds designed using a series of
GPCR-relevant scaffolds that mimic the beta-turn motif of endogenous peptide ligands. A random
selection taken from the entire GPCR Library have been validated against GPCR targets with both
agonists and antagonists being identified. Clients can custom select compounds from the GPCR Library.

Highlights
  • Lead-like and Drug-like compounds based on novel scaffolds
  • Custom select from more than 5,000 compounds
Characteristics

GPCR Library compounds are lead-like and drug-like and have the following physiochemical and
calculated property averages:

  • Molecular Weight Average: 417
  • Fsp3: Average: 0.5
  • clogP Average: 2.6
  • TPSA Average: 73
  • H-bond Donor Count Average: 1.1
  • H-bond Acceptor Count: Average = 4.7
  • Rotatable Bound Count Average: 5.3
Format
  • Download structures and custom select compounds from the GPCR Library SDfile
  • Compounds can be provided in 96-well and 384-well format
  • Available in 96-well or 384-well format including acoustic compatible plates
  • Amounts as low as 0.25 micromole (25ul of 10mM DMSO solution) available
  • Compounds are available as DMSO solutions or dry in micromole or mg amounts

For more information or a file of compound structures, please contact ChemBridge Sales