Targeted and
Specialty Libraries

CNS
Diverse, High-Quality Compounds for CNS Disease Research

ChemBridge has created a CNS-focused compound selection, the CNS-MPO Library, to support CNS drug discovery programs. Compounds from the library are predicted to have a higher probability of crossing the blood-brain barrier (BBB) based on a multiparameter optimization (MPO) approach. The CNS-MPO Library represents a subset of compounds from ChemBridge’s stock of more than 1.3 million lead-like and drug-like small molecule screening compounds representing a wide range of different chemotypes.

View and download a PDF of information on our chemical library for CNS focused disease research

 

Highlights
  • High quality, PAINS-free, small molecule compounds for CNS drug discovery
  • CNS MPO analysis applied to identify compounds with high probability of blood-brain barrier (BBB) penetration and improved clearance and safety profiles
  • Custom-select from more than 450,000 compounds to create a subset that meets your specific requirements; delivery as DMSO solutions or or in a dry format
  • Pre-selected subsets of 10,000 compounds each are also available; 5 non-overlapping subsets are available, offering up to 50,000 total pre-selected, pre-plated compounds; delivery as DMSO solutions or in a dry format

 

CNS Multiparameter Optimization (MPO) Score

A fundamental challenge for the design of CNS penetrant drugs is the need to cross the BBB. Physiochemical parameters for BBB permeable compounds form a smaller subset within the property space of oral drugs. To best define the physicochemical properties for CNS library design ChemBridge selected a weighted scoring approach described by Wager et al.1,2 The CNS MPO score is now a well-recognized algorithm in the CNS focused medicinal chemistry community. The algorithm uses a weighted scoring function assessing 6 key physicochemical properties (clogP, clogD, MW, TPSA, HBD, and pKa) for BBB penetration, CYP mediated metabolism and inhibition of dofetilide binding. The CNS MPO score is between 0 and 6.0 with scores ≥ 4.0 widely used as a cut-off to select compounds for hit finding in CNS therapeutic area drug discovery programs. A recent article assessing 616 compounds with measured unbound concentrations in the brain confirmed increasing CNS MPO score correlates with increased unbound concentration in the brain.3

 

Selection

The following approach was used to select compounds for inclusion in the CNS-MPO Library:

  • Filter to remove compounds with undesirable structural features including PAINS filters
  • Remove compounds with carboxylic acid groups due to low probability of BBB permeability4
  • MW range of 250 to 450 inclusive to allow for hit-finding or lead-like biased selections
  • CNS MPO score ≥ 4.0
  • Remove compounds with TPSA ≥ 100Å to eliminate high MPO score compounds with less desirable TPSA
  • Limit clogD range to 0 to 5.0 inclusive to eliminate high MPO score compounds with less desirable clogD values

The CNS-MPO Library selection can be further refined by using structural diversity analysis, by focusing on a hit-finding subset (MW range 300 to 450), or by focusing on a lead-like subset (MW range 250 to 400; TPSA ≤ 90Å; option to re-score using CNS Lead MPO5).

 

Format
  • Custom-select any number of compounds from the full file of more than 450,000 CNS-MPO Library compounds
  • Pre-selected subsets of 10,000 compounds each are also available with 5 non-overlapping subsets available, allowing the purchase of 10,000 to 50,000 CNS-MPO Library compounds in pre-selected, pre-plated format
  • Available in 384-well and 96-well formats including 384-well acoustic compatible plates
  • Amounts as low as 0.25 micromole (25ul of 10mM DMSO solution) available
  • Available as DMSO solutions or dry in micromole or mg amounts

 

Structure Files

For a file of the full CNS-MPO Library selection to use for custom-selection or for files the 5 pre-selected subsets (10,000 compounds each), please contact ChemBridge Sales

 

References
  1. Wager TT et al. Moving beyond rules: The development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties. ACS Chem. Neurosci. 2010 1, 435-449
  2. Wager TT et al. Central nervous system multiparameter optimization desirability: Application in drug discovery. ACS Chem. Neurosci. 2016 7, 767-7
  3. Rankovic Z CNS drug design: balancing physicochemical properties for optimal brain exposure. J. Med. Chem. 2015 58 (6), 2584–2608
  4. Ghose AK et al. Knowledge-based, central nervous system (CNS) lead selection and lead optimization for CNS drug discovery. ACS Chem. Neurosci. 2012 3, 50−68
  5. Mayol-Llinàs J et al. Assessing molecular scaffolds for CNS drug discovery. Drug Discov. Today. 2017 7, 965-969